The landscape of responses to neoadjuvant immunotherapy in resectable Kirsten rat sarcoma viral oncogene homolog‐mutant lung adenocarcinoma: Clinical heterogeneity and correlative immunologic analysis [PDF]
Clinical and Translational MedicineBackground Kirsten rat sarcoma viral oncogene homolog (KRAS)‐mutant lung adenocarcinoma (LUAD) typically demonstrates limited response to neoadjuvant immunotherapy (NIT).
Sikai Wu +6 more
doaj +3 more sources
Brain Expressed and X-Linked (Bex) Proteins Are Intrinsically Disordered Proteins (IDPs) and Form New Signaling Hubs [PDF]
PLoS ONE, 2015 Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation.
Marçal Vilar
exaly +3 more sources
Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review [PDF]
Journal of Advanced ResearchBackground: Brain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease.
Pingping Wang +10 more
doaj +2 more sources
Novel characterisation of microplastics and other contaminant particles using new scanning electron microscopy technologies [PDF]
Scientific ReportsScanning electron microscopy with combined backscattered electron and X-ray imaging (SEM-BEX) represents a new way to conduct direct visual assessment and elemental characterisation of particles in environmental samples up to 18× faster than standard ...
Max Webb +10 more
doaj +2 more sources
Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells [PDF]
CellsThe active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), binds to the vitamin D receptor (VDR) with high affinity. The VDR then heterodimerizes with the retinoid X receptor (RXR) and associates with vitamin D response elements (VDREs) to regulate ...
Mobin Emran Doost +6 more
doaj +2 more sources
Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting [PDF]
Journal of Biological EngineeringBackground Bleeding and traumatic injuries are still a major issue necessitating the development of advanced hemostatic materials that are economical, biocompatible, and effective.
Hassan Tavakoli +2 more
doaj +2 more sources
Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury [PDF]
Advanced ScienceDuring the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in TECs
Yu Yang +12 more
doaj +2 more sources
Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement
Pharmaceutics, 2022 Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug and thereby limits the clinical application.
Fu Xiao +7 more
doaj +1 more source
Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme
Frontiers in Oncology, 2022 Glioblastoma multiforme (GBM) is the most common, malignant, and deadly primary brain tumor in adults. Brain-expressed X-link (BEX) protein family is involved in tumorigenesis.
Adilai Aisa +10 more
doaj +1 more source
Inhibition of Candida albicans cell growth and biofilm formation by a bioactive extract produced by soil Streptomyces strain GCAL-25 [PDF]
Archives of Biological Sciences, 2018 Resistance to antifungal agents is a major public health concern since multidrug resistant (MDR) strains of Candida albicans have caused severe infections among immunosuppressed, diabetic and other hospital patients.
Córdova-Dávalos Laura E. +2 more
doaj +1 more source