Results 61 to 70 of about 6,009 (196)
Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine [PDF]
, 2013 BACKGROUND: Currently available therapies for Alzheimer's disease (AD) do not treat the underlying cause of AD. Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship between cancer and AD.
Adel Nefzi +7 more
core +1 more source
Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri +10 more
wiley +1 more source
Drugs in R&DBackground Bexarotene, which has been approved for use in Japan since 2016, is an effective drug for cutaneous T-cell lymphoma; however, careful management is imperative because of its adverse events. We previously demonstrated the severity of bexarotene-
Akimasa Sanagawa +5 more
doaj +1 more source
Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement
Pharmaceutics, 2022 Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug and thereby limits the clinical application.
Fu Xiao +7 more
doaj +1 more source
Identification and structural analysis of a novel ligand for Retinoic Acid Receptor β [PDF]
, 2016 维甲酸受体β（RetinoicAcidReceptorβ，RARβ）是维甲酸受体家族中（RetinoicAcidReceptorFamily）中重要的一员，其调控着胚胎发育、器官生成及细胞的增殖、分化、凋亡。同时，RARβ还是抑癌基因，它通过调控下游靶基因，以及参与COX-2和Caspase等信号通路抑制肿瘤细胞生长。其低表达量或活力的下降会诱发癌症，研究表明在众多癌组织或癌细胞中，RARβ是受抑制的，但是这种抑制作用是可以被RARβ的配体全反式维甲酸（AllTransRetinoicAcid，ATRA）
陈昂
core
Plantar keratoderma of Sézary syndrome [PDF]
, 2017 Sézary syndrome is an extremely rare form of cutaneous T-cell lymphoma. It presents suddenly and is associated with a poor prognosis. Clinical recognition is crucial for the diagnostic process and initiation of appropriate treatment.
Fragkos, KC
core +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.This minireview outlines recent advances in chain‐walking reactions of nonallylic alkenyl alcohols catalyzed by various transition metals, including palladium, ruthenium, rhodium, iridium, and nickel. Furthermore, the corresponding reaction mechanisms are discussed.
Yong Huang +5 more
wiley +1 more source
Mycosis fungoides and Sézary syndrome
British Journal of Haematology, Volume 208, Issue 4, Page 1207-1210, April 2026.Summary Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T‐cell lymphomas, arising from mature CD4+ memory T cells. Diagnosis is complex and relies on clinicopathological correlation, immunophenotyping and molecular clonality testing, while management is stage‐adapted, with potentially curative outcomes achievable only in ...
Francisco Martins, Joana Calvão
wiley +1 more source
PLoS ONE, 2019 IntroductionBexarotene, a retinoid X receptor agonist, improves cognition in murine models of Alzheimer's disease (AD). This study evaluated the effects of bexarotene on pathological and electrophysiological changes in very old triple transgenic AD mice (
Jonathan Mauricio Muñoz-Cabrera +7 more
doaj +1 more source
PLoS ONE, 2019 To gain a greater understanding of oral squamous cell carcinoma (OSCC) we investigated the actions of all-trans-retinoic acid (RA; a retinoid), bexarotene (a pan-RXR agonist), and forkhead box (FOX) transcription factors in human OSCC-derived cell lines.
Kwame Osei-Sarfo, Lorraine J Gudas
doaj +1 more source