Results 111 to 120 of about 22,851 (287)

Increase in Tetrahydrobiopterin Release from PC 12 Cells under Hypotonic Culture Conditions is Inhibited by HgCl2

Pteridines, 2005
Tetrahydrobiopterin (BH4) was released from PC 12 cells to the extracellular fluid. We found that the BH4 outward flow from the cells placed in Hanks medium was increased when NaCl concentration of the medium was decreased.
Nakanishi Nobuo, Kurihara Kinji, Tomomura Akito, Tonosaki Keiichi, Hattori Yoshiyuki, Oguro Kazuya, Hasegawa Hiroyuki   +6 more
doaj   +1 more source

Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria

Molecular Genetics and Metabolism Reports, 2017
Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.” Although prior research has identified biochemical and genotypic ...
Zoë Hawks, Joshua Shimony, Jerrel Rutlin, Dorothy K. Grange, Shawn E. Christ, Desirée A. White   +5 more
doaj   +1 more source

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

The First Crystallographic and Spectroscopic Characterization of a 3d-Metal Borohydride: Mn(BH4)2

, 2009
The first crystal structure of a 3d-metal borohydride is presented. Solvent-free homoleptic manganese borohydride Mn(BH4)2 forms at ambient conditions in ball-milled mixtures of alkali metal borohydrides and MnCl2. It crystallizes in the trigonal crystal
Penin, Nicolas, Radovan C ˇ Erný, Nicolas Penin, Yaroslav Filinchuk, Filinchuk, Yaroslav, Hagemann, Hans-Rudolf, Hans Hagemann, Cerny, Radovan   +7 more
core   +1 more source

Fast Room-Temperature Mg2+ Conductivity in Mg(BH4)21.6NH3Al2O3 Nanocomposites

, 2022
Design of new functional materials with fast Mg-ion mobility is crucial for the development of competitive solid-state magnesium batteries. Herein, we present new nanocomposites, Mg­(BH4)2·1.6NH3–Al2O3, reaching a high magnesium conductivity of σ­(Mg2+) =
Jan P. Embs, Jakob B. Grinderslev (5679236), Torben R. Jensen, Shanghai Wei (1846678), Jan P. Embs (2402815), Jørgen Skibsted, Torben R. Jensen (1267908), Tatsiana Burankova (3593522), Jakob B. Grinderslev, Tatsiana Burankova, Yigang Yan, Yigang Yan (1751413), Jørgen Skibsted (1458691), Shanghai Wei   +13 more
core   +1 more source

Recent progress in magnesium borohydride Mg(BH4)2: Fundamentals and applications for energy storage

, 2016
Magnesium borohydride (Mg(BH4)2) shows interesting properties both from fundamental and applicative points of view. Mg(BH4)2 has the most complex crystal structures and the largest number of phase polymorphs among other borohydrides.
Olena Zavorotynska, A. El-Kharbachi, S. Deledda, B. Hauback   +3 more
semanticscholar   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl [PDF]

, 2011
Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP3R) via its BH4 domain, thereby suppressing IP3R Ca2+-flux properties and protecting against Ca2+-dependent apoptosis. Here, we directly compared IP3R inhibition
Monaco, G, De Smedt, H, Bultynck, Geert, L Leybaert, H Akl, M De Maeyer, T Vervliet, Luyten, T, Parys, JB, J B Parys, Missiaen, L, Decrock, Elke, Vervliet, T, G Bultynck, C W Distelhorst, E Decrock, H De Smedt, Ponsaerts, Raf, Akl, H, Leybaert, Luc, G Monaco, De Maeyer, M, L Missiaen, T Luyten, Distelhorst, CW, R Ponsaerts   +25 more
core   +1 more source

Assessment of tetrahydrobiopterin responsiveness in Turkish hyperphenylalaninemic patients

The Turkish Journal of Pediatrics, 2007
Tetrahydrobiopterin (BH4) therapy is the latest alternative approach in phenylalanine hydroxylase (PAH) deficiency, and is suggested for a number of hyperphenylalaninemic (HPA) patients with certain mutations.
Sükran Yildirim, Ayşegül Tokatli, Engin Yilmaz, Turgay Coşkun   +3 more
doaj