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Statement of Retraction: Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition. [PDF]

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bHLH Transcription factors and mammalian neuronal differentiation

The International Journal of Biochemistry & Cell Biology, 1997
The basic helix-loop-helix (bHLH) factor Mash1 is expressed in the developing nervous system. Null mutation of Mash1 results in loss of olfactory and autonomic neurons and delays differentiation of retinal neurons, indicating that Mash1 promotes neuronal differentiation.
R, Kageyama, M, Ishibashi, K, Takebayashi, K, Tomita   +3 more
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Hey bHLH Transcription Factors

2014
Hey bHLH transcription factors are direct targets of canonical Notch signaling. The three mammalian Hey proteins are closely related to Hes proteins and they primarily repress target genes by either directly binding to core promoters or by inhibiting other transcriptional activators.
David, Weber, Cornelia, Wiese, Manfred, Gessler   +2 more
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Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist

Science, 1996
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome.
D B, Spicer, J, Rhee, W L, Cheung, A B, Lassar   +3 more
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SlbHLH152, a bHLH transcription factor positively regulates iron homeostasis in tomato

Plant Science, 2023
The maintain of iron (Fe) homeostasis is essential for plant survival. In tomato, few transcription factors have been identified as regulators of Fe homeostasis, among which SlbHLH068 induced by iron deficiency, plays an important role. However, the upstream regulator(s) responsible for activating the expression of SlbHLH068 remain(s) unknown.
Xiaoli, Li, Haohao, Cao, Deshui, Yu, Kedong, Xu, Yi, Zhang, Xinxin, Shangguan, Xiaohong, Zheng, Zhongzhou, Yang, Chaoqiong, Li, Xingchen, Pan, Yiming, Cui, Zhiqing, Zhang, Mengru, Han, Yiqing, Zhang, Qimeng, Sun, Huiling, Guo, Jingyi, Zhao, Lili, Li, Chengwei, Li   +18 more
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Sohlh2 is a germ cell-specific bHLH transcription factor

Gene Expression Patterns, 2006
Germ cell-specific transcriptional regulation is essential to understand pathways that confer germ cells their unique biology. Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis.
Daniel J, Ballow, Yun, Xin, Youngsok, Choi, Stephanie A, Pangas, Aleksandar, Rajkovic   +4 more
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Liverwort bHLH transcription factors and the origin of stomata in plants

Current Biology, 2023
Stomata are distributed in nearly all major groups of land plants, with the only exception being liverworts. Instead of having stomata on sporophytes, many complex thalloid liverworts possess air pores in their gametophytes. At present, whether stomata in land plants are derived from a common origin remains under debate.1,2,3 In Arabidopsis thaliana, a
Guanxiao Chang, Jianchao Ma, Shuanghua Wang, Mengmeng Tang, Bo Zhang, Yadi Ma, Lijuan Li, Guiling Sun, Shanshan Dong, Yang Liu, Yun Zhou, Xiangyang Hu, Chun-Peng Song, Jinling Huang   +13 more
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The evolution and structure/function of bHLH–PAS transcription factor family

Biochemical Society Transactions, 2022
Proteins that contain basic helix-loop-helix (bHLH) and Per-Arnt-Sim motifs (PAS) function as transcription factors. bHLH–PAS proteins exhibit essential and diverse functions throughout the body, from cell specification and differentiation in embryonic development to the proper function of organs like the brain and liver in adulthood. bHLH–PAS proteins
Hailey E. Edwards, Daniel A. Gorelick
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bHLH class transcription factors take centre stage in phytochrome signalling

Trends in Plant Science, 2005
The phytochrome family of photoreceptors (there are five phytochromes in Arabidopsis, named phyA to phyE) maximally absorbs red and far-red light and plays important functions throughout the life cycle of plants. Several recent studies have shown that multiple related bHLH (basic helix-loop-helix) class transcription factors play key roles in ...
Paula D, Duek, Christian, Fankhauser
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Inducing Neural Regeneration from Glia Using Proneural bHLH Transcription Factors

2023
Endogenous regeneration strategies to replace lost neurons hold great promise for treating neurodegenerative disorders. In the majority of cases, neural regeneration is induced by converting resident glial cells into neurogenic precursors. This review will outline how proneural bHLH transcription factors can be used to reprogram glia in the brain and ...
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