Cooperation between bHLH transcription factors and histones for DNA access [PDF]
Nature, 2023 AbstractThe basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs known as E-boxes (CANNTG) and includes 108 members1. Here we investigate how chromatinized E-boxes are engaged by two structurally diverse bHLH proteins: the proto-oncogene MYC-MAX and the circadian transcription factor CLOCK-BMAL1 (refs. 2,3).
Alicia K. Michael +26 more
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Insights into the diversification of subclade IVa bHLH transcription factors in Fabaceae [PDF]
BMC Plant Biology, 2020 Abstract Background Fabaceae plants appear to contain larger numbers of subclade IVa basic-helix-loop-helix (bHLH) transcription factors than other plant families, and some members of this subclade have been identified as saponin biosynthesis regulators. We aimed to systematically elucidate the
Hayato Suzuki +2 more
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Role and functioning of bHLH transcription factors in jasmonate signalling [PDF]
Journal of Experimental Botany, 2016 Plant growth, development and interaction with the environment involve the action of multiple phytohormones. Transcription factors (TFs) of diverse families play essential roles in the signalling cascades triggered by the perception of a particular hormone.
Jonas Goossens +2 more
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Transcription factor VvibHLH93 negatively regulates proanthocyanidin biosynthesis in grapevine
Frontiers in Plant Science, 2022 Proanthocyanidins (PAs) derived from grape berries determine the astringency and bitterness of red wines. The two leucoanthocyanidin reductases (VviLAR1 and VviLAR2) are crucial for PA accumulation in grapevine.
Jing Cheng +10 more
doaj +1 more source
Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]
, 2018 The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao +3 more
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Mutation of a bHLH transcription factor allowed almond domestication [PDF]
Science, 2019 How to make almonds palatable The domesticated almond tree has been feeding humans for millennia. Derivation from the wild, bitter, and toxic almond required loss of the cyanogenic diglucoside amygdalin. Sánchez-Pérez et al.
R. Sánchez-Pérez1 +23 more
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Structural characterization of mammalian bHLH-PAS transcription factors [PDF]
Current Opinion in Structural Biology, 2017 The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1.
Dalei, Wu, Fraydoon, Rastinejad
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Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis [PDF]
, 2007 Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors ...
Anderson, David J. +6 more
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A seed-specific regulator of triterpene saponin biosynthesis in Medicago truncatula [PDF]
, 2020 Plants produce a vast array of defense compounds to protect themselves from pathogen attack or herbivore predation. Saponins are a specific class of defense compounds comprising bioactive glycosides with a steroidal or triterpenoid aglycone backbone. The
Arendt, Philipp +11 more
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Cell Reports, 2021 Summary: The basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME-INTERACTING FACTOR 7 (PIF7) is a central regulator that promotes stem growth by activating growth-related gene expression during shade-avoidance responses.
Chuanwei Yang +7 more
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