Results 121 to 130 of about 60,389 (159)

Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist

Science, 1996
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome.
D B, Spicer, J, Rhee, W L, Cheung, A B, Lassar   +3 more
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SlbHLH152, a bHLH transcription factor positively regulates iron homeostasis in tomato

Plant Science, 2023
The maintain of iron (Fe) homeostasis is essential for plant survival. In tomato, few transcription factors have been identified as regulators of Fe homeostasis, among which SlbHLH068 induced by iron deficiency, plays an important role. However, the upstream regulator(s) responsible for activating the expression of SlbHLH068 remain(s) unknown.
Xiaoli, Li, Haohao, Cao, Deshui, Yu, Kedong, Xu, Yi, Zhang, Xinxin, Shangguan, Xiaohong, Zheng, Zhongzhou, Yang, Chaoqiong, Li, Xingchen, Pan, Yiming, Cui, Zhiqing, Zhang, Mengru, Han, Yiqing, Zhang, Qimeng, Sun, Huiling, Guo, Jingyi, Zhao, Lili, Li, Chengwei, Li   +18 more
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Sohlh2 is a germ cell-specific bHLH transcription factor

Gene Expression Patterns, 2006
Germ cell-specific transcriptional regulation is essential to understand pathways that confer germ cells their unique biology. Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis.
Daniel J, Ballow, Yun, Xin, Youngsok, Choi, Stephanie A, Pangas, Aleksandar, Rajkovic   +4 more
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Liverwort bHLH transcription factors and the origin of stomata in plants

Current Biology, 2023
Stomata are distributed in nearly all major groups of land plants, with the only exception being liverworts. Instead of having stomata on sporophytes, many complex thalloid liverworts possess air pores in their gametophytes. At present, whether stomata in land plants are derived from a common origin remains under debate.1,2,3 In Arabidopsis thaliana, a
Guanxiao Chang, Jianchao Ma, Shuanghua Wang, Mengmeng Tang, Bo Zhang, Yadi Ma, Lijuan Li, Guiling Sun, Shanshan Dong, Yang Liu, Yun Zhou, Xiangyang Hu, Chun-Peng Song, Jinling Huang   +13 more
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The evolution and structure/function of bHLH–PAS transcription factor family

Biochemical Society Transactions, 2022
Proteins that contain basic helix-loop-helix (bHLH) and Per-Arnt-Sim motifs (PAS) function as transcription factors. bHLH–PAS proteins exhibit essential and diverse functions throughout the body, from cell specification and differentiation in embryonic development to the proper function of organs like the brain and liver in adulthood. bHLH–PAS proteins
Hailey E. Edwards, Daniel A. Gorelick
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bHLH class transcription factors take centre stage in phytochrome signalling

Trends in Plant Science, 2005
The phytochrome family of photoreceptors (there are five phytochromes in Arabidopsis, named phyA to phyE) maximally absorbs red and far-red light and plays important functions throughout the life cycle of plants. Several recent studies have shown that multiple related bHLH (basic helix-loop-helix) class transcription factors play key roles in ...
Paula D, Duek, Christian, Fankhauser
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Inducing Neural Regeneration from Glia Using Proneural bHLH Transcription Factors

2023
Endogenous regeneration strategies to replace lost neurons hold great promise for treating neurodegenerative disorders. In the majority of cases, neural regeneration is induced by converting resident glial cells into neurogenic precursors. This review will outline how proneural bHLH transcription factors can be used to reprogram glia in the brain and ...
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The bHLH transcription factor AhbHLH121 improves salt tolerance in peanut

International Journal of Biological Macromolecules
Plants have developed a number of protective mechanisms to respond to salt and other stresses. Previous studies have shown that the basic helix-loop-helix (bHLH) transcription factor AhbHLH121 plays a crucial role in the response to abiotic stresses in peanut, but the mechanisms and functions related to AhbHLH121 remain unclear. In the current research,
Xiaobo, Zhao, Qi, Wang, Caixia, Yan, Quanxi, Sun, Juan, Wang, Chunjuan, Li, Cuiling, Yuan, Yifei, Mou, Shihua, Shan   +8 more
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Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1

Journal of Endocrinological Investigation, 2003
Among the transcription factors involved in pituitary ontogenesis and physiology, basic helix-loop-helix (bHLH) have been poorly studied. Members of bHLH family include NeuroD1 and ASH1, both involved in neuroendocrine differentiation. We evaluated their mRNA expression patterns, by semi-quantitative RT-PCR analysis (sq-RT-PCR) and/or Northern blot, in
Ferretti E, Di Stefano D, Zazzeroni F, Gallo R, Fraticci A, Carfagnini R, Angiulli S, Santoro A, Minniti G, Tamburrano G, ALESSE, Edoardo, Cantore G, Gulino A, Jaffrain Rea ML   +13 more
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BHLH transcription factor manipulation in human glioma

2014
Summary Glioblastoma multiforme (GBM) are the most aggressive type of gliomas and lead to poor prognosis. Despite modern multimodal therapy, relapse recurs in up to 90% of all cases and the survival of patients is around one year in average. GBM are highly heterogenous at the genomic, histopathological and disease progression level, which represents a ...
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