Results 41 to 50 of about 61,968 (230)

New insights into the mechanisms of phytochrome-cryptochrome coaction. [PDF]

, 2018
Contents Summary 547 I. Introduction 547 II. Phytochromes mediate light-induced transcription of BICs to inactivate cryptochromes 548 III. PPKs phosphorylate light-signaling proteins and histones to affect plant development 548 IV.
Ahmad, Bourbousse, Bourbousse, Casas-Mollano, Cashmore, Devlin, Guo, Hoecker, Huang, Hughes, Huq, Ichikawa, Jang, Leivar, Lian, Liu, Liu, Liu, Lu, Ma, Martinez-Garcia, Mas, Mohr, Ni, Ni, Ni, Nusinow, Pedmale, Quail, Rosenfeldt, Saijo, Sang, Sellaro, Shalitin, Sheerin, Su, Su, Tessadori, Tessadori, Wang, Wang, Wang, Wang, Wang, Weidler, Yang, Zheng, Zuo   +47 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Characterization of the bHLH family of transcriptional regulators in the acoel S. roscoffensis and their putative role in neurogenesis

EvoDevo, 2018
Background The basic helix-loop-helix (bHLH) family of transcription factors is one of the largest superfamilies of regulatory transcription factors and is widely used in eukaryotic organisms.
E. Perea-Atienza, S. G. Sprecher, P. Martínez   +2 more
doaj   +1 more source

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas [PDF]

, 2000
Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins.
Anderson, David J., Conners, Jennifer R., German, Michael S., Johnson, Jeffrey D., Kalamaras, Julie, Lee, Jacqueline E., Scheel, David W., Schwitzgebel, Valérie M., Sussel, Lori   +8 more
core  

The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription [PDF]

, 2014
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
A Alboresi, A Ben-Shem, A Fukushima, A Kunihiro, A Pokhilko, A Pokhilko, B Al-Sady, B Berckmans, C Andronis, C Kami, CS Hardtke, D Alabadi, D Chen, DC Rockholm, E Huq, E Lopez-Juez, E Park, G Toledo-Ortiz, Gabriela Toledo-Ortiz, Gavin Steel, H Shen, H Shen, H Zhang, Henrik Johansson, J Foreman, J Lee, J Li, J Moon, J Shin, J Shin, J Shin, J Soy, J Sun, JA Stavang, JC del Pozo, JF Martinez-Garcia, JM Tepperman, Jordi Bou-Torrent, K Kobayashi, K Nozue, KA Franklin, KA Franklin, KA Franklin, Karen J. Halliday, Kelly Stewart, Keun Pyo Lee, KK Niyogi, Li-Jia Qu, M de Lucas, M Havaux, MA Koini, Manuel Rodríguez-Concepción, MC Proveniers, MF Covington, MH Walter, MT Osterlund, N Mochizuki, N Mochizuki, OS Lau, P Hornitschek, P Hornitschek, P Leivar, P Leivar, P Leivar, P Leivar, PG Stephenson, PH Quail, PH Quail, R Catala, R Henriques, R Welsch, S Chattopadhyay, S Ito, S Lorrain, S Makino, S Reinbothe, S Toh, SV Kumar, T Legnaioli, T Oyama, T Yamashino, T Yamashino, W Huang, Y Niwa, Y Nomoto, Y Nomoto, Y Zhang, Y Zhang, Y Zhang   +88 more
core   +5 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The spatiotemporal profile of Dendrobium huoshanense and functional identification of bHLH genes under exogenous MeJA using comparative transcriptomics and genomics

Frontiers in Plant Science, 2023
IntroductionAlkaloids are one of the main medicinal components of Dendrobium species. Dendrobium alkaloids are mainly composed of terpene alkaloids. Jasmonic acid (JA) induce the biosynthesis of such alkaloids, mainly by enhancing the expression of JA ...
Xiaomei He, Wenwu Zhang, Irfan Ali Sabir, Chunyan Jiao, Guohui Li, Yan Wang, Fucheng Zhu, Jun Dai, Longyun Liu, Cunwu Chen, Yingyu Zhang, Cheng Song   +11 more
doaj   +1 more source

Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10 [PDF]

, 2013
The plant hormone jasmonate (JA) activates gene expression by promoting ubiquitin-dependent degradation of JAZ transcriptional repressor proteins. A key feature of all JAZ proteins is the highly conserved Jas motif, which mediates both JAZ degradation ...
Campos, Marcelo L., Chung, Hoo Sun, He, Sheng Hang, Howe, Gregg A., Moreno, Javier Edgardo, Patel, Lalita C., Shyu, Christine, Yao, Jian   +7 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Speedy grass stomata: emerging molecular and evolutionary features [PDF]

, 2017
No abstract ...
Blatt, Michael R., Cai, Shengguan, Chen, Zhong-Hua, Papanatsiou, Maria   +3 more
core   +1 more source