Results 81 to 90 of about 61,968 (230)

Breeding for multi‐stress resilience in crops: Myth or possibility?

PLANTS, PEOPLE, PLANET, EarlyView.
Climate change threatens millions of farmers worldwide by exposing crops to multiple concurrent or sequential environmental stresses such as drought, heat, waterlogging, and diseases. Although crops have long been selected under naturally occurring multi‐stress conditions, breeding pipelines largely focus on optimal or single‐stress environments ...
Hamid Khazaei, Ian C. Dodd, Rodomiro Ortiz   +2 more
wiley   +1 more source

Lotus tenuis x L. corniculatus interspecific hybridization as a means to breed bloat-safe pastures and gain insight into the genetic control of proanthocyanidin biosynthesis in legumes [PDF]

, 2014
Background: Proanthocyanidins (PAs) are secondary metabolites that strongly affect plant quality traits. The concentration and the structure of these metabolites influence the palatability and nutritional value of forage legumes. Hence, modulating PAs in
Babuin, María Florencia, Carrasco, Pedro, Damiani, Francesco, Escaray, Francisco José, Marco, Francisco, Paolocci, Francesco, Passeri, Valentina, Pieckenstain, Fernando Luis, Ruiz, Oscar Adolfo   +8 more
core   +2 more sources

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

Cell Reports, 2013
FOXO transcription factors are central regulators of longevity from worms to humans. FOXO3, the FOXO isoform associated with exceptional human longevity, preserves adult neural stem cell pools.
Ashley E. Webb, Elizabeth A. Pollina, Thomas Vierbuchen, Noelia Urbán, Duygu Ucar, Dena S. Leeman, Ben Martynoga, Madhavi Sewak, Thomas A. Rando, François Guillemot, Marius Wernig, Anne Brunet   +11 more
doaj   +1 more source

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4 [PDF]

, 2017
Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs).
Cai, Xinzhang, Chen, Hongsheng, Feng, Yong, He, Chufeng, Li, Jiada, Liu, Huadie, Liu, Xueming, Liu, Yalan, Mei, Lingyun, Peng, Zhen, Song, Jian, Vleminckx, Kris   +11 more
core   +1 more source

Elucidating the genetic basis of antioxidant status in lettuce (Lactuca sativa). [PDF]

, 2015
A diet rich in phytonutrients from fruit and vegetables has been acknowledged to afford protection against a range of human diseases, but many of the most popular vegetables are low in phytonutrients. Wild relatives of crops may contain allelic variation
Biggi, Gaia F, Chapman, Mark A, Clarkson, Graham Jj, Damerum, Annabelle, Hancock, Robert D, Michelmore, Richard W, Rothwell, Steve D, Selmes, Stacey L, Shellcock, Connie, Taylor, Gail, Truco, Maria José   +10 more
core   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Comparative genomic analysis of bHLH genes across multiple species uncovers a novel gene regulating ginsenoside biosynthesis in Panax ginseng

BMC Plant Biology
Background Basic helix–loop–helix (bHLH) transcription factors are the second largest transcription factor family in plants and regulate diverse physiological processes.
Xiaochen Yu, Mingming Liu, Jinghui Yu, Yang Jiang, Sizhang Liu, Jingang Mo, Yi Wang   +6 more
doaj   +1 more source

Fluorescence Resonance Energy Transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteins

Biological Procedures Online, 2004
Post-translational modifications such as phosphorylation play a vital role in the regulation of protein function. In our study of the basic Helix-loop-Helix (bHLH) transcription factor HAND1, we show that HAND1 is phosphorylated during the trophoblast ...
Centonze Victoria E., Firulli Beth A., Firulli Anthony B.   +2 more
doaj   +1 more source