Results 91 to 100 of about 11,641 (225)

Weight Loss With GLP‐1 Agonists in Nondiabetic Adults: Systematic Review and Network Meta‐Analysis

Obesity, Volume 34, Issue 6, Page 1210-1229, June 2026.
ABSTRACT Objective Two glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) (semaglutide and liraglutide) and one dual agonist (tirzepatide) are FDA‐approved for weight loss in adults with obesity without type 2 diabetes mellitus. This systematic review and network meta‐analysis aims to compare the efficacy of these agents against each other.
Michael Lim, Pooja Gokhale, Akwasi Akosah, Lorenzo Villa‐Zapata   +3 more
wiley   +1 more source

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists

Frontiers in Pharmacology, 2015
G protein-coupled receptors (GPCRs) are involved in essentially all physiological processes in mammals. The classical GPCR signal transduction mechanism occurs by coupling to G protein, but it has recently been demonstrated that interaction with β ...
Geisa A Santos, Diego A Duarte, Lucas T Parreiras-e-Silva, Felipe R Teixeira, Felipe R Teixeira, Rafael M Silva-Rocha, Eduardo B Oliveira, Michel eBouvier, Claudio M Costa-Neto, Claudio M Costa-Neto   +9 more
doaj   +1 more source

Social information about others' affective states in a human‐altered world

Journal of Animal Ecology, EarlyView.
Faced with anthropogenic change, animals now encounter challenges different from their evolutionary past. To cope with such challenges, animals may use social information about others' affective states to guide their decisions. Considering affective states of wild animals could have important implications for animal welfare and wildlife conservation ...
Luca G. Hahn, Jordan McDowall, Margaux Vanhussel, Mike Mendl, Alex Thornton   +4 more
wiley   +1 more source

Modeling Skin Mark Temporal Variations to Estimate the Sex of Delphinids with Low Sexual Dimorphism: Implications for Management and Conservation

Integrative Zoology, EarlyView.
This work aimed to apply the principles of skin mark analysis to a cetacean species to build a sex‐discrimination model exclusively based on photographic material. Relevant differences between sexes emerged in markings, with males presenting more social, aggression‐related, and fishing‐related marks overall, and a stronger tendency of mark accumulation
Alice Turchi, Giulia Pedrazzi, Alex Mattiussi, Maria S. Labriola, Daniele Petrone, Sofia Rinalduzzi, Giancarlo Giacomini, Daniela Silvia Pace   +7 more
wiley   +1 more source

The Role of β-Arrestin Proteins in Organization of Signaling and Regulation of the AT1 Angiotensin Receptor

Frontiers in Endocrinology, 2019
AT1 angiotensin receptor plays important physiological and pathophysiological roles in the cardiovascular system. Renin-angiotensin system represents a target system for drugs acting at different levels.
Gábor Turu, Gábor Turu, András Balla, András Balla, László Hunyady, László Hunyady   +5 more
doaj   +1 more source

Protease-activated receptor 2 : are common functions in glial and immune cells linked to inflammation-related CNS disorders? [PDF]

, 2015
Protease-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) whose activation requires the cleavage of the N-terminus by a serine protease.
Bushell, Trevor J., Cunningham, Margaret R., McIntosh, Kathryn A., Moudio, Serge, Plevin, Robin   +4 more
core   +1 more source

Fulfilling the Promise of "Biased" G Protein–Coupled Receptor Agonism [PDF]

Molecular Pharmacology, 2015
The fact that over 30% of current pharmaceuticals target heptahelical G protein-coupled receptors (GPCRs) attests to their tractability as drug targets. Although GPCR drug development has traditionally focused on conventional agonists and antagonists, the growing appreciation that GPCRs mediate physiologically relevant effects via both G protein and ...
Luttrell, Louis M., Maudsley, Stuart, Bohn, Laura M.   +2 more
openaire   +3 more sources

What is (de)politicization and what is wrong with it?

American Journal of Political Science, EarlyView.
Abstract This article attempts to clarify the meaning of (de)politicization. Politicization sometimes refers to the inappropriate intrusion of partisan loyalties in nonpolitical social domains (affective politicization). Politicization can also constitute an ideal of civic agency and energy (contestatory politicization).
Dimitrios Halikias
wiley   +1 more source

Limited Evidence of Noradrenaline Use and Effectiveness in Preterm Neonates: A Systematic Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The study aimed to analyse the effects and associated outcomes of noradrenaline in treating hypotension in preterm neonates. Methods We searched PubMed, Web of Science, and Scopus to August 2025 for randomised and observational studies on noradrenaline use in preterm neonates.
A. Vänskä, U. Sankilampi, I. Kuitunen
wiley   +1 more source

Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity

Molecular Metabolism
Biased agonism of the glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptors (GLP-1R/GIPR) yields greater weight loss and better glycemic control than unbiased agonism in preclinical models.
Manu V. Chakravarthy, Ruben Rodriguez, Anne Hergarden, Michael A. Elliott, Juan P. Frias, Federico A. Argüelles-Tello, Edgar Tenorio, Jonathan E. Rankin, Jingtao Wu, Shyam Krishnan, Daniel A. Erlanson, Raymond V. Fucini, Derek Bone, Jeffrey S. Iwig, Luis Acosta, Ashley Untereiner, Asmita Pant, Avalon Patton, Leyla L. Sanchez-Sanchez, Jian Luo, Alexandra Steinberg, Damian Bialonczyk, Stig K. Hansen   +22 more
doaj   +1 more source