Results 81 to 90 of about 11,411 (182)
Frontiers in Pharmacology, 2015 G protein-coupled receptors (GPCRs) are involved in essentially all physiological processes in mammals. The classical GPCR signal transduction mechanism occurs by coupling to G protein, but it has recently been demonstrated that interaction with β ...
Geisa A Santos +9 more
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Coping strategies in captive capuchin monkeys (Sapajus spp.) [PDF]
, 2016 Studies on diverse species indicate the existence of individual differences in stress coping strategies labelled as ‘proactive’ and ‘reactive’. Identifying taxonomic distribution of such coping strategies is fundamental to evolutionary models and to ...
Aruajo, Talita +5 more
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Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts [PDF]
, 2016 Background and Purpose Human lung fibroblasts (HLF) express high levels of the LPA1 receptor, a GPCR that responds to the endogenous lipid mediator, lysophosphatidic acid (LPA).
Dowling, Mark R, +2 more
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Frontiers in Endocrinology, 2019 AT1 angiotensin receptor plays important physiological and pathophysiological roles in the cardiovascular system. Renin-angiotensin system represents a target system for drugs acting at different levels.
Gábor Turu +5 more
doaj +1 more source
Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]
, 2018 The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E +4 more
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Efficacy of modified atkins ketogenic diet in chronic cluster headache. An open-label, single-arm, clinical trial [PDF]
, 2018 Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.
Cherubino Di Lorenzo +9 more
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Short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension [PDF]
, 2018 Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models.
Alastalo +23 more
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Molecular MetabolismBiased agonism of the glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptors (GLP-1R/GIPR) yields greater weight loss and better glycemic control than unbiased agonism in preclinical models.
Manu V. Chakravarthy +22 more
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G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning
Scientific Reports, 2017 Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority.
Lauriane Onfroy +6 more
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Opening the Field of Integrin Biology to “Biased Agonism” [PDF]
Circulation Research, 2011 See related article, pages 1269–1279 Integrins are α- and β-subunit heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands central to inflammation, immunity, hemostasis, and tumor metastasis.1 Integrins have been viewed to function within a 2-state model. In
openaire +2 more sources