Results 11 to 20 of about 175 (164)

Renal bicarbonate reabsorption during bicarbonate loading

Kidney International, 1980
To examine bicarbonate reabsorption at different GFR's, we varied the renal perfusion pressure in anesthetized dogs after inhibiting autoregulation by expanding extracellular volume and infusing ethacrynic acid. At a plasma bicarbonate concentration (PHCO3) of 28 +/- 1 mM, bicarbonate reabsorption varied in proportion to GFR (glomerulotubular balance).
Fredrik Kiil, Øystein Mathisen, Tom Monclair   +2 more
openaire   +3 more sources

There is more to an elevated bicarbonate [PDF]

Journal of Clinical Sleep Medicine, 2021
Citation:Hadigal S, Ryals S, Wagner M, Berry R. There is more to an elevated bicarbonate. J Clin Sleep Med. 2021;17(1):111–112.
Susheela Hadigal, Richard B. Berry, Mary H. Wagner, Scott Ryals   +3 more
openaire   +2 more sources

Transmembrane Transport of Bicarbonate Unravelled [PDF]

Chemistry – A European Journal, 2021
AbstractInvited for the cover of this issue are Dr. Stephen Butler, Dr. Hennie Valkenier and co‐workers at Université Libre de Bruxelles, Loughborough University, Masaryk University, and the University of Bristol. The image depicts the transport of bicarbonate anions versus the spontaneous diffusion of CO2 across the lipid bilayer of a liposome.
Luis Martínez‐Crespo, Sarah H. Hewitt, Nicola Alessandro De Simone, Vladimír Šindelář, Anthony P. Davis, Stephen Butler, Hennie Valkenier   +6 more
openaire   +10 more sources

Critical role of bicarbonate and bicarbonate transporters in cardiac function

World Journal of Biological Chemistry, 2014
Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. Along with accompanying H(+), HCO3 (-) is generated from CO2 and H2O, either spontaneously or via the catalytic activity of carbonic anhydrase. It serves as a component of the major buffer system, thereby playing a critical role in pH homeostasis. Bicarbonate can also
Hong-Sheng Wang, Yamei Chen, Gary E. Shull, Kanimozhi Vairamani   +3 more
openaire   +3 more sources

BICARBONATE OF POTASH IN INFLUENZA. [PDF]

The Lancet, 1893
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openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Airway epithelial cells: ‘Bicarbonate in’≠‘Bicarbonate out’

The Journal of Physiology, 2012
The importance of intracellular and extracellular pH to physiological function is unquestioned. There are few scenarios in which pathological processes do not include aberrant pH. For example, cystic fibrosis, a genetic disease that adversely affects airways and other epithelia throughout the body, is associated with secretions that have abnormally low
openaire   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Reaction Mechanism of the Selective Reduction of CO$_2$ to CO by a Tetraaza [Co$^\text{II}$N$_4$H]$^{2+}$ Complex in the Presence of Protons [PDF]

, 2018
The tetraaza [Co$^\text{II}$N$_4$H]$^{2+}$ complex (\textbf{1}) is remarkable for its ability to selectively reduce CO$_2$ to CO with 45\% Faradaic efficiency and a CO to H$_2$ ratio of 3:2. We employ density functional theory (DFT) to determine the reasons behind the unusual catalytic properties of \textbf{1} and the most likely mechanism for CO$_2 ...
arxiv   +1 more source