Results 51 to 60 of about 106,770 (379)
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
The assessment of water quality in river Molo water basin, Kenya
Applied Water Science, 2020 The monitoring of water quality for both domestic and commercial use is absolutely essential for policy formulation that affects both public and environmental health.
Emily B. Chebet +2 more
doaj +1 more source
Reclamation of filtered bicarbonate
Kidney International, 1990 Approximately 85% of the filtered bicarbonate load is reabsorbed in the proximal convoluted tubule. Transport in this segment displays saturation kinetics, and exhibits a higher capacity for reabsorption in the earliest portion. Reclamation of bicarbonate is highly regulated in the proximal tubule: an increase in luminal [HCO3-], flow rate and arterial
openaire +3 more sources
Bicarbonate in cystic fibrosis [PDF]
Journal of Cystic Fibrosis, 2017 Cystic fibrosis (CF, mucoviscidosis) is caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), which is a chloride and bicarbonate channel necessary for fluid secretion and extracellular alkalization. For a long time, research concentrated on abnormal Cl- and Na+ transport, but neglected bicarbonate as a crucial factor ...
Hans Beat Hadorn +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Journal of the Turkish Chemical Society Section B: Chemical Engineering, 2022 In this study, we report the photocatalytic activity of TiO2 monitored by benzene oxidation in the grout medium. The results of the batch reaction tests indicated that the activity of TiO2 coated on grout was substantially less than TiO2 coated on a ...
Mert OYMAK , Deniz UNER
doaj
Sensors, 2019 Polystyrene cross-linked with divinylbenzene and functionalized by a quaternary ammonium cation anion site is used as the membrane of a hydrogencarbonate (i.e., bicarbonate) ion-selective electrode.
Sylwia Dabrowska +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source