Results 41 to 50 of about 3,975 (165)

Real‐world use and effectiveness of fostemsavir in a US clinical setting: Insights from Trio Health HIV Research Network

HIV Medicine, EarlyView.
Abstract Objective To describe real‐world patterns of use, virologic and immunologic outcomes and treatment persistence among people with HIV (PWH) initiating fostemsavir (FTR) in a diverse US cohort. Design Retrospective cohort study of adults receiving FTR in clinical practice, stratified by baseline viral suppression status.
Richard Elion, Cassidy Henegar, Isobel McEwen, Andrew Frick, Moti Ramgopal, Steven Santiago, Karam Mounzer, Gregory Huhn, Charles Walworth, Leigh Ragone, Vani Vannappagari   +10 more
wiley   +1 more source

Viro-Immunological Efficacy and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide among Women Living with HIV: A 96-Week Post-Switch Analysis from the Real-Life SHiNe-SHiC Cohort

Biomedicines
Background/Objectives: Out of 39.9 million adults living with HIV in 2022, 20 million were women. Despite bearing a significant burden, women remain underrepresented in clinical trials, including those for antiretroviral treatments (ART).
Agnese Colpani, Andrea De Vito, Andrea Marino, Manuela Ceccarelli, Benedetto Maurizio Celesia, Giuseppe Nicolò Conti, Serena Spampinato, Giulia Moi, Emmanuele Venanzi Rullo, Giovanni Francesco Pellicanò, Sonia Agata Sofia, Grazia Pantò, Carmelo Iacobello, Chiara Maria Frasca, Arturo Montineri, Antonio Albanese, Goffredo Angioni, Bruno Cacopardo, Giordano Madeddu, Giuseppe Nunnari, on behalf of Sardinian HIV Network and Sicilian HIV Cohort (SHiNe-SHiC) Research Group   +20 more
doaj   +1 more source

2‐Chloro‐5‐(trifluoromethyl)aniline‐Derived Schiff Base Palladium(II) Complexes: From Molecular Design to Acute Toxicity Assessment

ChemistryOpen, Volume 15, Issue 10, October 2026.
Four new Schiff bases derived from 2‐chloro‐5‐(trifluoromethyl)aniline and their corresponding palladium(II) complexes were obtained and analyzed by multiple spectroscopic techniques. Single‐crystal X‐ray diffraction elucidated the structures of all the ligands and complexes 2 and 4. Their toxicity was assessed on Triticum aestivum L.
Andreea Elena Ştefan, Cristina Elena Dinu‐Pîrvu, Sergiu Shova, Ştefania Felicia Bărbuceanu, Teodora Venera Apostol, Diana Carolina Ilieş, Mihaela Badea, Mihaela Dinu, Robert Viorel Ancuceanu, Doina Drăgănescu, Elena Pahonţu   +10 more
wiley   +1 more source

Bictegravir combined with emtricitabine and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial [PDF]

, 2019
Background: Bictegravir co-formulated with emtricitabine and tenofovir alafenamide as a fixed-dose combination is recommended for treatment of HIV-1-infection and might be better tolerated than other integrase inhibitor-based single-tablet regimens, but ...
Thompson, M.A., Ramgopal, M.N., Hagins, D., Antinori, A., Brinson, C., Acosta, R., Baumgarten, A., Yazdanpanah, Y., Wohl, D.A., Wei, X., Martin, H., Collins, S.E., Brainard, D., Clarke, A.   +13 more
core   +1 more source

Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes [PDF]

, 2022
Altres ajuts: European Regional Development Fund (FEDER); Gilead. European Union NextGeneration EU/PRTR.Aims: To assess the potential direct effects of the integrase strand-transfer inhibitors (INsTIs) dolutegravir, bictegravir, and raltegravir, drugs ...
Corbacho, Noemí, Giralt, Marta, Quesada-López, Tania, Mateo, Maria Gracia, Mur, Isabel, Villarroya, Francesc, Gutierrez, Mª del Mar, Domingo, Joan Carles, Villarroya, Joan, Domingo, Pere, Cairó, Montserrat   +10 more
core   +1 more source

Bictegravir/Emtricitabine/Tenofovir Alafenamide in Adults with HIV/HBV Coinfection: An Open-Label, Single-Arm, Safety and Efficacy Switch Study

Viruses
Background: HIV and hepatitis B virus (HBV) coinfection has been associated with a higher risk of morbidity and mortality. HBV-active antiretroviral regimens have significantly improved the outcomes for coinfected people.
Helena Kwakwa, Jacqueline Bran, Julia Ruff, Salma Sharaf, Hyunuk Seung, Sunny Choe, Joel V. Chua   +6 more
doaj   +1 more source

Outcomes After Switching to BIC/FTC/TAF in Patients with Virological Failure to Protease Inhibitors or Non-Nucleoside Reverse Transcriptase Inhibitors: A Real-World Cohort Study

Infection and Drug Resistance, 2021
Hui-Min Chang,1– 3 Pei-Yun Chou,4,5 Chen-Hsi Chou,2 Hung-Chin Tsai4– 6 1Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung ...
Chang HM, Chou PY, Chou CH, Tsai HC
doaj  

Prevalence and Risk Factors for Poor Sleep Quality in People Living with HIV: Preliminary Observations from an HIV Outpatient Clinic

Viruses, 2023
Introduction: Sleep disorders have been reported in individuals living with HIV (PLWH), with a prevalence rate of over 50%. The main risk factors contributing to the development of sleep disturbances are not yet fully understood.
Giuseppe Bruno, Massimo Giotta, Serena Perelli, Vito Spada, Maria Antonietta Purgatorio, Nicola Bartolomeo, Giovanni Battista Buccoliero   +6 more
doaj   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

Gut microbiota differences linked to weight gain and ART in people living with HIV are enterotype specific and minor compared to the large differences linked to sexual behavior

Frontiers in Cellular and Infection Microbiology
IntroductionSpecific antiretroviral therapy (ART) regimens are associated with weight gain in people living with HIV (PLWH). Gut microbiota is involved in weight gain in humans and animals.
Jan Kehrmann, Alireza Dostmohammadi, Anna-Lena Stumpf, Lara Best, Leah Consten, Hannah Sievert, Felix Maischack, Stefanie Sammet, Sarah Albayrak-Rena, Ann-Kathrin Doerr, Katharina Bohlen, Otgonzul von Velsen, Otgonzul von Velsen, Ivana Kraiselburd, Christina B. Karsten, Farnoush Farahpour, Farnoush Farahpour, Folker Meyer, Stefan Esser, Jan Buer   +19 more
doaj   +1 more source