Results 91 to 100 of about 21,536 (218)

Risk factors for paravalvular leak after transcatheter aortic valve replacement [PDF]

, 2019
Objective. To assess risk factors for paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) in a large single-center cohort, including measurement of aortic valve calcification using a reproducible method. Methods.
Pollari, Francesco
core  

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance:The BASIK2 Rationale and Trial Design [PDF]

, 2018
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS ...
Bas Kietselaer, Baumgartner, Casper Mihl, Frederique Peeters, Harry Crijns, Jan Bucerius, Joachim Wildberger, Lang, Leon Schurgers, Manouk van Mourik, Marc Dweck, Rudski, Schurgers, Simon Schalla, Steven Meex, Suzanne Gerretsen, Vahanian   +16 more
core   +2 more sources

Aortic valve dysfunction and aortic dilatation in adults with coarctation of the aorta [PDF]

, 2013
Objectif: Déterminer la prévalence de la dysfonction de la valve aortique, de la dilatation de l'aorte proximale et des interventions au niveau de la valve aortique et de l'aorte ascendante chez les adultes avec une coarctation de l'aorte.
Clair, M.
core  

Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? [PDF]

, 2016
Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV).
Bogers, A.J.J.C. (Ad), DeRuiter, M.C. (Marco), Franken, R. (Romy), Gittenberger-de Groot, A.C. (Adriana), Goumans, M.-J. (Marie-José), Grewal, N. (Nimrat), Jongbloed, M.R.M. (Monique), Klautz, R.J.M. (Robert), Lindeman, J.H.N. (Johannes), Mulder, B.J.M. (Barbara), Poelmann, R.E. (Robert)   +10 more
core   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCongenital heart disease is the most common type of birth defect, affecting ≈2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bicuspid aortic
Sara N. Koenig, Kevin Bosse, Uddalak Majumdar, Elizabeth M. Bonachea, Freddy Radtke, Vidu Garg   +5 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. [PDF]

, 2015
The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life.
Andrews, WD, Mommersteeg, MT, Parnavelas, JG, Yeh, ML   +3 more
core   +1 more source