Results 91 to 100 of about 15,320 (206)

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

Sixteen year retrospective analysis of rheumatic and non-rheumatic heart disease patients undergoing valve procedures at Groote Schuur Hospital first incidence single aortic and mitral valve replacement

, 2012
Includes abstract.Includes bibliographical references.Rheumatic heart disease is still the most common cause of valvular heart lesions requiring replacement or repair procedures worldwide.
Ogunrombi, Akinwumi Babatunde
core  

Bicuspid Aortic Valve Disease: Classifications, Treatments, and Emerging Transcatheter Paradigms

, 2023
\ua9 2023 The Author(s)Bicuspid aortic valve (BAV) is a common congenital valvular malformation, which may lead to early aortic valve disease and bicuspid-associated aortopathy.
Alkhalil M, Jarral O, Rodes-Cabau J, Majmundar M, Das R, Dykun I, Patel KN, Kalra A, Candreva A, Rehman SM, Puri R, Reardon MJ   +11 more
core  

Characterization of an induced pluripotent stem cell line (NCHi024-A) from a male infant with bicuspid aortic valve

Stem Cell Research
Bicuspid aortic valve is one of the most common congenital heart defects which have only two leaflets instead of three. NCHi024-A is an induced pluripotent stem cell (iPSC) line derived from peripheral blood mononuclear cells (PBMCs) of a male infant ...
Jiyoon Lee, Meghan Hanley, Shiqiao Ye, Yang Yu, Aaron Argall, Ming-Tao Zhao   +5 more
doaj   +1 more source

Retrospective Cross‐Sectional Study of Transthoracic Echocardiographic Reports in Patients Diagnosed With Aortic Regurgitation in Mashhad, Iran; to Evaluate Echocardiographic Determinants of AR Severity, With Specific Focus on STJ‐Related Parameters

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Aortic regurgitation (AR) is associated with characteristic changes in aortic root geometry. Data on detailed echocardiographic patterns of AR in Iranian cohorts remain limited. This study aimed to describe the echocardiographic and etiologic characteristics of patients with AR and to assess the associations between ...
Ali Haghighi, Hedieh Alimi, Vafa Baradaran Rahimi   +2 more
wiley   +1 more source

The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes.

PLoS ONE, 2014
Aortic valve calcification is a significant and serious clinical problem for which there are no effective medical treatments. Individuals born with bicuspid aortic valves, 1-2% of the population, are at the highest risk of developing aortic valve ...
Katrina Carrion, Jeffrey Dyo, Vishal Patel, Roman Sasik, Salah A Mohamed, Gary Hardiman, Vishal Nigam   +6 more
doaj   +1 more source

Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis

Precision Medical Sciences, Volume 15, Issue 2, Page 70-79, June 2026.
Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan, Muneeb Khawar, Asad Ullah Farooq, Azooba Khalid, Syed Muhammad Ahsan, M. Hamza Naseer Awan, Muhammad Soban Nisar, Asim Elahi, Muhammad Aqib Faizan, Iqra Shahid, Abdullah Munir Ahmed, Faseeh Haider, Rejina Chhetri   +12 more
wiley   +1 more source

Chronic Otitis Media Resulting in Aortic Valve Replacement: A Case Report

Journal of Tehran University Heart Center, 2015
The bicuspid aortic valve is known to be the most common congenital cardiac malformation, with an approximate incidence rate of 1-2% in the general population. Most patients are unaware of the disease until the onset of infective endocarditis, which is a
Adem Guler, Mehmet Ali-Sahin, Fahri Gurkan-Yesil, Uzeyir Yildizoglu, Sait Demirkol, Mehmet Arslan   +5 more
doaj  

Heartbeat: phenotypic heterogeneity of bicuspid aortic valve disease [PDF]

Heart, 2018
Bicuspid aortic valve (BAV) disease is common, affecting 1%–2% of the entire population, with nearly all BAV patients eventually requiring aortic valve replacement, often with concurrent aortic surgery for dilation of the sinuses or ascending aorta. Although echocardiography allows easy diagnosis of the presence of BAV disease early in life, we are ...
openaire   +2 more sources

Etiology of bicuspid aortic valve disease: Focus on hemodynamics

World Journal of Cardiology, 2014
The bicuspid aortic valve (BAV) is the most common form of inheritable cardiac defect. Although this abnormality may still achieve normal valvular function, it is often associated with secondary valvular and aortic complications such as calcific aortic valve disease and aortic dilation.
Samantha K, Atkins, Philippe, Sucosky
openaire   +2 more sources