Results 71 to 80 of about 59,398 (195)

Bicuspid Aortic Valve in Children and Young Adults for Cardiologists and Cardiac Surgeons: State-of-the-Art of Literature Review

Journal of Cardiovascular Development and Disease
Bicuspid aortic valve disease is the most prevalent congenital heart disease, affecting up to 2% of the general population. The presentation of symptoms may vary based on the patient’s anatomy of fusion, with transthoracic echocardiography being the ...
Francesco Nappi, Sanjeet Singh Avtaar Singh, Paolo M. de Siena   +2 more
doaj   +1 more source

Genome-wide analysis yields new loci associating with aortic valve stenosis

Nature Communications, 2018
Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental ...
Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigurdsson, Peter Almgren, Olle Melander, Anders Franco-Cereceda, Anders Hamsten, Lars Fritsche, Maoxuan Lin, Bo Yang, Whitney Hornsby, Dongchuan Guo, Chad M. Brummett, Gonçalo Abecasis, Michael Mathis, Dianna Milewicz, Simon C. Body, Per Eriksson, Cristen J. Willer, Kristian Hveem, Christopher Newton-Cheh, J. Gustav Smith, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson   +45 more
doaj   +1 more source

Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model

Frontiers in Cardiovascular Medicine, 2022
Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and hemodynamic) have been suggested ...
María Teresa Soto-Navarrete, María Teresa Soto-Navarrete, Bárbara Pozo-Vilumbrales, Bárbara Pozo-Vilumbrales, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Carmen Rueda-Martínez, M. Carmen Fernández, M. Carmen Fernández, M. Carmen Fernández, Ana Carmen Durán, Ana Carmen Durán, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Borja Fernández, Borja Fernández, Borja Fernández   +21 more
doaj   +1 more source

Marfan Syndrome Versus Bicuspid Aortic Valve Disease: Comparative Analysis of Obstetric Outcome and Pregnancy-Associated Immediate and Long-Term Aortic Complications

Journal of Clinical Medicine, 2020
Pregnancy poses a threat to women with aortopathy. Conclusive data on the obstetric and aortic outcome in this risk collective, especially when it comes to aortic complications in the long term, are still missing. This study offers a comparative analysis
B. Toprak, K. Szöcs, E. Zengin-Sahm, C. Sinning, Amra Hot, P. Bannas, K. Hecher, B. Hüneke, T. Mir, M. Rybczynski, E. Girdauskas, S. Blankenberg, Y. von Kodolitsch   +12 more
semanticscholar   +1 more source

Increased calcification by erythrophagocytosis in aortic valvular interstitial cells

ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin, Magnus Bäck, Anders Franco‐Cereceda, Sven‐Christian Pawelzik   +3 more
wiley   +1 more source

Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis

REC: Interventional Cardiology (English Ed.), 2023
CASE PRESENTATION This is the case of an 82-year-old man with a past medical history of permanent atrial fibrillation, chronic obstructive pulmonary disease, and stable Alzheimer’s disease admitted due to heart failure.
Julia Martínez-Sole, Sílvia Lozano-Edo, Francisco Ten-Morro, Luis Andrés-Lalaguna, Jorge Sanz-Sánchez, José Luis Díez-Gil   +5 more
doaj   +1 more source

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve

Nature Communications
Bicuspid aortic valve, a prevalent congenital malformation, predisposes individuals to severe complications. Although the condition exhibits substantial heritability, known protein-coding and common regulatory mutations explain a minority of cases.
Artemy Zhigulev, Andrey Buyan, Enikő Lázár, Nikita Gryzunov, Karin Lång, Raphaël Mauron, Vladimir Nozdrin, Rapolas Spalinskas, Sailendra Pradhananga, Madeleine Petersson Sjögren, Doreen Schwochow, Anders Franco-Cereceda, Joakim Lundeberg, Ivan V. Kulakovskiy, Per Eriksson, Hanna M. Björck, Pelin Sahlén   +16 more
doaj   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Point on the Aortic Bicuspid Valve

Life, 2022
Background—Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease in the world. Knowledge about its subtypes origin, development, and evolution is poor despite the frequency and the potential gravity of this condition.
Chloé Bernard, Marie Catherine Morgant, David Guillier, Nicolas Cheynel, Olivier Bouchot   +4 more
doaj   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source