Results 61 to 70 of about 15,320 (206)

Genome-wide analysis yields new loci associating with aortic valve stenosis

Nature Communications, 2018
Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental ...
Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigurdsson, Peter Almgren, Olle Melander, Anders Franco-Cereceda, Anders Hamsten, Lars Fritsche, Maoxuan Lin, Bo Yang, Whitney Hornsby, Dongchuan Guo, Chad M. Brummett, Gonçalo Abecasis, Michael Mathis, Dianna Milewicz, Simon C. Body, Per Eriksson, Cristen J. Willer, Kristian Hveem, Christopher Newton-Cheh, J. Gustav Smith, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson   +45 more
doaj   +1 more source

Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis

REC: Interventional Cardiology (English Ed.), 2023
CASE PRESENTATION This is the case of an 82-year-old man with a past medical history of permanent atrial fibrillation, chronic obstructive pulmonary disease, and stable Alzheimer’s disease admitted due to heart failure.
Julia Martínez-Sole, Sílvia Lozano-Edo, Francisco Ten-Morro, Luis Andrés-Lalaguna, Jorge Sanz-Sánchez, José Luis Díez-Gil   +5 more
doaj   +1 more source

Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Novel stent technologies offer early intravascular treatment options for coarctation (COA). Mid‐to‐long‐term cardiovascular responses to early COA stent interventions are undefined. Aims We studied a porcine model of COA, with and without early stent implantation with serial dilation to adult aortic diameters, aiming to define ...
Leah M. Gober, Michael A. Stellon, Matt A. Culver, Amy Frenkel, Dana Irrer, Colleen M. Witzenburg, Alejandro Roldán‐Alzate, Luke Lamers   +7 more
wiley   +1 more source

Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model

Frontiers in Cardiovascular Medicine, 2022
Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and hemodynamic) have been suggested ...
María Teresa Soto-Navarrete, María Teresa Soto-Navarrete, Bárbara Pozo-Vilumbrales, Bárbara Pozo-Vilumbrales, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Carmen Rueda-Martínez, M. Carmen Fernández, M. Carmen Fernández, M. Carmen Fernández, Ana Carmen Durán, Ana Carmen Durán, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Borja Fernández, Borja Fernández, Borja Fernández   +21 more
doaj   +1 more source

Aortic Dissection After Previous Aortic Valve Replacement for Bicuspid Aortic Valve Disease

Journal of the American College of Cardiology, 2015
The effect of bicuspid aortic valve (BAV) phenotype on the future risk of type A aortic dissection is unknown. On the basis of previous data [(1)][1], we hypothesized that the risk of post–aortic valve replacement (AVR) aortic dissection might be different in BAV insufficiency versus BAV ...
Girdauskas, Evaldas, Rouman, Mina, Disha, Kushtrim, Espinoza, Andres, Misfeld, Martin, Borger, Michael A., Kuntze, Thomas   +6 more
openaire   +3 more sources

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Collegiate Wrestler With a Bicuspid Aortic Valve and Aortic Dilation

, 2022
Bicuspid aortic valve and aortopathy are generally considered contraindications to isometric exercise. For athletes with mild disease at low risk of adverse events, a shared decision-making approach for continued sports participation is reasonable.
Chokshi, Neel, Chhana, Rahul, Rymer, Christopher, Krishnan, Sheela, Husaini, Mustafa, Vidula, Mahesh, Fayock, Kristopher, Kusmiesz, Chris, Glassberg, Helene, Sivalokanathan, Sanjay   +9 more
core   +1 more source

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve

Nature Communications
Bicuspid aortic valve, a prevalent congenital malformation, predisposes individuals to severe complications. Although the condition exhibits substantial heritability, known protein-coding and common regulatory mutations explain a minority of cases.
Artemy Zhigulev, Andrey Buyan, Enikő Lázár, Nikita Gryzunov, Karin Lång, Raphaël Mauron, Vladimir Nozdrin, Rapolas Spalinskas, Sailendra Pradhananga, Madeleine Petersson Sjögren, Doreen Schwochow, Anders Franco-Cereceda, Joakim Lundeberg, Ivan V. Kulakovskiy, Per Eriksson, Hanna M. Björck, Pelin Sahlén   +16 more
doaj   +1 more source

Novel Phenotypes in Bicuspid Aortic Valve Disease

, 2011
Bicuspid aortic valve (BAV) is the most common congenital abnormality of the human heart, affecting approximately 1-2% of the general population (Williams, 2006). It is widely accepted that BAV is a very heterogeneous disease and that the different phenotypes of BAV disease may be caused by unique pathogenetic mechanisms.
Girdauskas, Evaldas, A., Michael, Kuntze, Thomas   +2 more
openaire   +3 more sources

Increased calcification by erythrophagocytosis in aortic valvular interstitial cells

ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin, Magnus Bäck, Anders Franco‐Cereceda, Sven‐Christian Pawelzik   +3 more
wiley   +1 more source