Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease. [PDF]
Elife, 2021 Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA).
Abudupataer M +17 more
europepmc +2 more sources
Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease. [PDF]
Molecules, 2021 Bicuspid aortic valve (BAV) is the most common congenital heart defect responsible for valvular and aortic complications in affected patients. Causes and mechanisms of this pathology are still elusive and thus the lack of early detection biomarkers leads
Chessa M +7 more
europepmc +2 more sources
Medial tunica degeneration of the ascending aortic wall is associated with specific microRNA changes in bicuspid aortic valve disease. [PDF]
Mol Med Rep, 2021 Ascending aortic diameter is not an accurate parameter for surgical indication in patients with bicuspid aortic valve (BAV). Thus, the present study aimed to identify specific microRNAs (miRNAs/miRs) and their expression levels in aortic wall aneurysm ...
Pisano C +10 more
europepmc +2 more sources
Multimodal Assessment of Vascular and Ventricular Function in Children and Adults With Bicuspid Aortic Valve Disease. [PDF]
Front Cardiovasc Med, 2021 Background: Bicuspid aortic valve (BAV), the most common congenital cardiac anomaly, has been associated with an aortopathy, increased aortic stiffness and diastolic dysfunction. The involved mechanisms and impact of age remain unclear. It was the aim of
Weismann CG +3 more
europepmc +2 more sources
Bicuspid Aortic Valve Disease: A Comprehensive Review
Cardiology Research and Practice, 2012 Bicuspid aortic valve is the commonest congenital cardiac abnormality in the general population. This paper article will discuss our current knowledge of the anatomy, pathophysiology, genetics, and clinical aspects of bicuspid aortic valve disease.
Ify Mordi, Nikolaos Tzemos
doaj +4 more sources
Aortic Valve Dysfunction and Aortopathy Based on the Presence of Raphe in Patients with Bicuspid Aortic Valve Disease. [PDF]
J Cardiovasc Dev Dis, 2023 Zhang Y +4 more
europepmc +3 more sources
Bicuspid aortic valve associated aortopathy: a genetic disease? [PDF]
Cardiogenetics, 2015 The present paper briefly reviews the literature supporting the pathogenetic importance of hemodynamics in the development of bicuspid aortic valve-associated aortopathy.
Ciro Bancone +2 more
doaj +5 more sources
Left ventricular remodelling in bicuspid aortic valve disease.
European Heart Journal - Cardiovascular Imaging, 2021 AIMS Characterization of left ventricular (LV) geometric pattern and LV mass could provide an important insight into the pathophysiological adaptations of the LV to pressure and/or volume overload in patients with bicuspid aortic valve (BAV) and ...
S. Butcher +25 more
semanticscholar +5 more sources
SA Heart Journal, 2017 The prevalence of bicuspid aortic valve (BAV) disease is 0.5 - 2% of the population with a 3:1 male predominance. The genetic basis remains unknown although 9% of families have more than one affected individual.
Lee, James C. , Otto, Catherine M.
doaj +3 more sources
Transcatheter aortic valve implantation in moderate bicuspid aortic valve disease in a patient with end-stage dilated cardiomyopathy - bridge to heart transplantation. [PDF]
Postepy Kardiol Interwencyjnej, 2021 Mizia-Szubryt M +5 more
europepmc +3 more sources