Results 91 to 100 of about 34,851 (281)

Aortendilatation und Funktion des linken Ventrikels bei bikuspider Aortenklappe [PDF]

, 2015
Einleitung: Die bikuspide Aortenklappe (BAK) ist mit einer Prävalenz von 0.5-2% der häufigste angeborene Herzfehler. Die Dilatation der Aorta ascendens ist eine häufige Begleiterkrankung der BAK, die im schlimmsten Fall zum plötzlichen Herztod bei ...
Fina, Fabienne, Frangi, Jana
core   +1 more source

Valve-preserving root replacement in bicuspid aortic valves [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2010
Bicuspid aortic valve anatomy is associated with aortic root aneurysm in a relevant proportion of patients. These patients require root replacement for prognostic reasons, and the valve may be preserved. The objective of this analysis is to analyze the early and late outcomes of root remodeling for bicuspid aortic valve.Between November 1995 and ...
Schäfers, Hans-Joachim, Kunihara, Takashi, Fries, Peter, Brittner, Brigitte, Aicher, Diana   +4 more
openaire   +2 more sources

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

P4.03 APOPTOSIS IN THE MEDIA OF THE AORTIC WALL AND ITS RELATIONSHIP WITH AORTIC VALVE MORPHOLOGY IN AORTIC DILATATION

Artery Research, 2013
Background: The aortic valve is normally tricuspid but may vary in that it can be made up of 1, 2 or 4 leaflets with each of these often associated with aortopathy, most commonly aortic dilatation.
H. Edwards, J. Dargan, L. Elliot, A. Modi, S. Ohri, P. Townsend   +5 more
doaj   +1 more source

Study of the correlation between bicuspid aortic valve and the development of aortic dissection [PDF]

, 2017
La disección aórtica (AD) es la condición letal más comúnmente diagnosticada de la arteria aorta y consiste en el redireccionamiento del flujo sanguíneo desde el lumen de la aorta hasta la media de la pared de la aorta a través de una pequeña fisura en ...
Ruiz Jiménez, Elvira
core  

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2genes in familial cases of bicuspid aortic valve [PDF]

, 2013
BACKGROUND: The purpose of our study was to investigate the potential contribution of germline mutations in NOTCH1, GATA5 and TGFBR1 and TGFBR2 genes in a cohort of Italian patients with familial Bicuspid Aortic Valve (BAV). METHODS: All the coding exons
Cecilia Vecoli, Ilenia Foffa, Lamia Ait Alì, Maria Grazia Andreassi, Massimiliano Mariani, Nicoletta Botto, Paola Panesi, Pierluigi Festa   +7 more
core   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Reparación valvular aórtica bicúspide. Resultados

Cirugía Cardiovascular, 2020
Resumen: Introducción y objetivos: Las guías de práctica clínica no mencionan, específicamente, la reparación valvular en pacientes con insuficiencia aórtica y válvula aórtica bicúspide como alternativa al implante protésico. La reparación en bicúspides
Rubén Álvarez-Cabo, Carlota Vigil-Escalera, Alain E. Escalera, Blanca Meana Fernández, María Martín, Carlota Salmerón, Rocío Díaz Méndez, Daniel Hernández-Vaquero, Juan Meca, Pilar Mencía, Martín Zabala Morales, Francisco Callejo Magaz, Juan Carlos Llosa, Carlos Morales Pérez, Jacobo Silva Guisasola   +14 more
doaj   +1 more source