β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice. [PDF]
PLoS ONEThoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Cilostazol, a phosphodiesterase (PDE) 3 inhibitor, and sildenafil, a PDE5 inhibitor, have been used clinically for peripheral arterial disease and erectile ...
Samuel C Tyagi +7 more
doaj +2 more sources
Exploring ethnic differences in the perioperative course of thoracic aortopathy [PDF]
Frontiers in Cardiovascular MedicineBackgroundIn patients with thoracic aortopathy post-operative recovery can be complicated by a lack of consistent, clear communication and guidance. Despite the growing recognition of these challenges, the specific needs of patients undergoing aortic ...
Nora Bacour +7 more
doaj +2 more sources
First-trimester aortic root replacement in a pregnant woman with previously undiagnosed Marfan syndrome [PDF]
European Journal of Case Reports in Internal MedicineAortopathy encompasses a spectrum of aortic aneurysms and dissections and represents a major cause of cardiovascular morbidity during pregnancy, particularly in women with heritable connective tissue disorders such as Marfan syndrome.
Anara Abbay +4 more
doaj +2 more sources
Aortopathy in Tetralogy of Fallot – Insights from a single-center observational study [PDF]
Annals of Pediatric CardiologyObjective: The objective of this study was to assess the presence of aortopathy on follow-up in operated and unoperated adolescent and adult patients with Tetralogy of Fallot (TOF) and to identify the various associated factors.
Usnish Adhikari +3 more
doaj +2 more sources
Emerging imaging and circulating biomarkers in relation to underlying mechanisms in Bicuspid Aortic Valve aortopathy [PDF]
International Journal of Cardiology: Heart & VasculatureBicuspid Aortic Valve (BAV) is the most prevalent congenital heart defect with an autosomal dominant inheritance. With up to 2% of the general population affected by the condition, mortality remains high likely due to the development of aortopathy which ...
Hamza M Ahmad +4 more
doaj +2 more sources
Connective tissue disorder and high risk pregnancy: a case series with personalised external aortic root support (PEARS) [PDF]
Nature CommunicationsAortopathy including Marfan (MFS) and Loeys-Dietz syndrome (LDS) poses a high risk of aortic dissection, particularly during pregnancy and the puerperium.
Claudia Montanaro +12 more
doaj +2 more sources
Aortopathy associated with bicuspid aortic valve: advances in clinical and hemodynamics research [PDF]
Frontiers in PhysiologyHaving a bicuspid aortic valve (BAV) is the most common congenital heart disease, affecting 0.5%–2% of the population, with significant heterogeneity in clinical presentation, complications, and outcomes.
Minghui Yang +4 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2021 Background: Using echocardiographic surveillance, many patients are diagnosed with bicuspid aortic valve (BAV) without significant valve dysfunction. Limited data are available regarding the progression and outcomes of non-dysfunctional BAV.Methods and ...
Shinjeong Song +5 more
doaj +1 more source
Long-term outcomes in heritable thoracic aortic disease
Frontiers in Cardiovascular Medicine, 2022 Heritable aortic aneurysm is an increasingly recognized cause of morbidity and mortality. Whilst Marfan syndrome (MFS) is well-known, the clinical presentation and prognosis of more newly described genetic syndromes is less familiar to clinicians.
Elizabeth N. Robertson +7 more
doaj +1 more source
Clinical implications of the biomechanics of bicuspid aortic valve and bicuspid aortopathy
Frontiers in Cardiovascular Medicine, 2022 Bicuspid aortic valve (BAV), which affects up to 2% of the general population, results from the abnormal fusion of the cusps of the aortic valve. Patients with BAV are at a higher risk for developing aortic dilatation, a condition known as bicuspid ...
Ali Fatehi Hassanabad +9 more
doaj +1 more source