Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy [PDF]
Frontiers in Physiology, 2017 Bicuspid aortic valve (BAV) is a common congenital cardiac malformation affecting 1–2% of people. BAV results from fusion of two adjacent aortic valve cusps, and is associated with dilatation of the aorta, known as bicuspid valve associated aortopathy ...
Ali Fatehi Hassanabad +8 more
doaj +2 more sources
Aortopathy in Tetralogy of Fallot – Insights from a single-center observational study
Annals of Pediatric CardiologyObjective: The objective of this study was to assess the presence of aortopathy on follow-up in operated and unoperated adolescent and adult patients with Tetralogy of Fallot (TOF) and to identify the various associated factors.
Usnish Adhikari +3 more
doaj +2 more sources
Emerging imaging and circulating biomarkers in relation to underlying mechanisms in Bicuspid Aortic Valve aortopathy [PDF]
International Journal of Cardiology: Heart & VasculatureBicuspid Aortic Valve (BAV) is the most prevalent congenital heart defect with an autosomal dominant inheritance. With up to 2% of the general population affected by the condition, mortality remains high likely due to the development of aortopathy which ...
Hamza M Ahmad +4 more
doaj +2 more sources
Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy
iScienceSummary: Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS).
Junichi Saito +3 more
doaj +2 more sources
Hypoxia-Inducible Factor 1α in the Aortic Wall: Protective Adaptation or Marker of a Vulnerable Phenotype? [PDF]
FASEB JThe FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Grewal N.
europepmc +2 more sources
Thoracic Aortic Dissection in a Patient With Classical Homocystinuria: Implications for Aortic Surveillance. [PDF]
JIMD RepABSTRACT Classical homocystinuria (OMIM #236300), a rare inherited metabolic disorder caused by cystathionine beta‐synthase (CBS) deficiency, is characterized by markedly elevated homocysteine levels and associated multisystem complications. While the role of homocystinuria in venous thromboembolism is well recognized, there is limited evidence of ...
Chard M, Zhang JS, Turner L.
europepmc +2 more sources
Microcalcification and Thoracic Aortopathy: A Window into Disease Severity [PDF]
, 2022 Background: Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic
Bouchareb, Rihab +41 more
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Bicuspid aortopathy or bicuspid aortopathies? The risk in generalizing [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2008 n ...
DELLA CORTE, Alessandro, COTRUFO M.
openaire +3 more sources
Is the intimal thickness a key contributor to thoracic aortopathy? [PDF]
, 2023 Background: An aortic dissection is the most devastating complication of thoracic aortic disease. Several non- and syndromic conditions such as a bicuspid aortic valve (BAV) and Marfan syndrome (MFS) have a severely increased risk to develop a thoracic ...
Poelmann, Robert +5 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2022 Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and hemodynamic) have been suggested ...
María Teresa Soto-Navarrete +21 more
doaj +1 more source