Results 31 to 40 of about 5,408 (223)
Genetics of Heritable Thoracic Aortic Disease
Cardiogenetics, 2022 Genetic testing plays an increasing diagnostic and prognostic role in the management of patients with heritable thoracic aortic disease (HTAD). The identification of a specific variant can establish or confirm the diagnosis of syndromic HTAD, dictate ...
Efstathios Papatheodorou +2 more
doaj +1 more source
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
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Bicuspid Aortic Valve: a Review with Recommendations for Genetic Counseling [PDF]
, 2016 Bicuspid aortic valve (BAV) is the most common congenital heart defect and falls in the spectrum of left-sided heart defects, also known as left ventricular outflow tract obstructive (LVOTO) defects.
Freeze, Samantha L. +3 more
core +1 more source
Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
core +1 more source
Ventricular‐Vascular Coupling in Marfan and Non‐Marfan Aortopathies [PDF]
, 2016 Background: Marfan syndrome (MFS) and familial non–syndromal thoracic aortic aneurysm and dissection (ns‐TAAD) are genetic aortopathies causing aortic dilatation with increased aortic stiffness.
Hambly, Brett +7 more
core +1 more source
DNA Methylation Analysis of Turner Syndrome BAV
Frontiers in Genetics, 2022 Turner Syndrome (TS) is a rare cytogenetic disorder caused by the complete loss or structural variation of the second sex chromosome. The most common cause of early mortality in TS results from a high incidence of left-sided congenital heart defects ...
Jacob Gutierrez +8 more
doaj +1 more source
Real-time Assessment of Right and Left Ventricular Volumes and Function in Children Using High Spatiotemporal Resolution Spiral bSSFP with Compressed Sensing [PDF]
, 2018 Background: Real-time (RT) assessment of ventricular volumes and function enables data acquisition during free-breathing. However, in children the requirement for high spatiotemporal resolution requires accelerated imaging techniques.
Hughes, Marina +5 more
core +2 more sources
Frontiers in Physiology, 2017 Bicuspid aortic valve (BAV) is a common congenital cardiac malformation affecting 1–2% of people. BAV results from fusion of two adjacent aortic valve cusps, and is associated with dilatation of the aorta, known as bicuspid valve associated aortopathy ...
Ali Fatehi Hassanabad +8 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 (1) Background: To identify the association between the presence or absence of a raphe and aortic valve dysfunction, as well as the presence of aortopathy in patients with a bicuspid aortic valve (BAV); (2) Methods: This retrospective study enrolled 312 ...
Yu Zhang +4 more
doaj +1 more source
Bicuspid aortic valve associated aortopathy: a genetic disease?
Cardiogenetics, 2015 The present paper briefly reviews the literature supporting the pathogenetic importance of hemodynamics in the development of bicuspid aortic valve-associated aortopathy.
Ciro Bancone +2 more
doaj +1 more source