Results 11 to 20 of about 4,070 (210)
Aortopathy – A surgical pathology experience
Indian Journal of Pathology and MicrobiologyBackground: Aortopathy is a non-inflammatory and non-atherosclerotic disease of aorta that results from significant ‘degenerative’ changes in the media. This often leads to thoracic aortic aneurysms and/or dissections in young individuals.
Pradeep Vaideeswar, Sujit Udayaravi
doaj +4 more sources
JTCVS Open, 2023 Objective: Genetic aortopathy, if left untreated, leads to aortic catastrophe in most affected individuals. We sought to determine the genetic mutation patterns and detection rates in patients with aortopathy and their families with a systematic ...
Jihoon Kim, MD, PhD +6 more
doaj +3 more sources
Progress in Cardiovascular Diseases, 2020 The aortopathy associated with bicuspid aortic valve (BAV) is an epidemiologically relevant source of chronic and acute aortic disease (aneurysm and dissection). However, its pathogenesis is still the object of scientific uncertainties and debates. Indeed, the mechanisms determining the diseases of the ascending aorta in BAV patients are most likely ...
Lo Presti, Federica +4 more
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, 2017 This is the first textbook to focus on Aortopathy, a new clinical concept for a form of vasculopathy. The first section of the book starts from discussing general concept and history of Aortopathy, and then deals with its pathophysiology, manifestation ...
Julie De Backer +2 more
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Bicuspid aortic valve associated aortopathy: a genetic disease?
Cardiogenetics, 2015 The present paper briefly reviews the literature supporting the pathogenetic importance of hemodynamics in the development of bicuspid aortic valve-associated aortopathy.
Ciro Bancone +2 more
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TIMP3 and TIMP1 are risk genes for bicuspid aortic valve and aortopathy in Turner syndrome. [PDF]
PLoS Genetics, 2018 Turner syndrome is caused by complete or partial loss of the second sex chromosome, occurring in ~1 in 2,000 female births. There is a greatly increased incidence of aortopathy of unknown etiology, including bicuspid aortic valve (BAV), thoracic aortic ...
Holly Corbitt +7 more
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A Novel Human Biospecimen Repository for Clinical and Molecular Investigation of Thoracic Aortopathy
Cardiogenetics, 2021 Thoracic aortic aneurysm (TAA) is a heritable aortopathy with significant morbidity and mortality, affecting children and adults. Genetic causes, pathobiological mechanisms, and prognostic markers are incompletely understood.
Courtney E. Vujakovich +1 more
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Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives
International Journal of Cardiology, 2019 Bicuspid aortic valve (BAV) is the most frequent cardiac congenital valvular disease. Although the BAV risk of first degree relatives (FDR) has been assessed (7-9%), there is little information as to the heritable risk for aortopathy.Identify the specific risk for regional aortopathy in FDR with tricuspid aortic valve (TAV) of BAV patients according to
Dayan V +9 more
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β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice.
PLoS ONEThoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Cilostazol, a phosphodiesterase (PDE) 3 inhibitor, and sildenafil, a PDE5 inhibitor, have been used clinically for peripheral arterial disease and erectile ...
Samuel C Tyagi +7 more
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Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
Journal of Cardiovascular Development and Disease, 2015 Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role.
Sara N. Koenig +4 more
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