Results 41 to 50 of about 5,408 (223)

Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? [PDF]

, 2016
Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV).
Bogers, A.J.J.C. (Ad), DeRuiter, M.C. (Marco), Franken, R. (Romy), Gittenberger-de Groot, A.C. (Adriana), Goumans, M.-J. (Marie-José), Grewal, N. (Nimrat), Jongbloed, M.R.M. (Monique), Klautz, R.J.M. (Robert), Lindeman, J.H.N. (Johannes), Mulder, B.J.M. (Barbara), Poelmann, R.E. (Robert)   +10 more
core   +1 more source

Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

Journal of Cardiovascular Development and Disease, 2015
Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role.
Sara N. Koenig, Kevin M. Bosse, Holly A. Nadorlik, Brenda Lilly, Vidu Garg   +4 more
doaj   +1 more source

Aortic Dilatation in Patients With Bicuspid Aortic Valve

Frontiers in Physiology, 2021
Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality. BAV aortic dilatation is associated with an increased risk of adverse aortic events and represents a potentially lethal disease and hence a considerable medical burden.
Jing Wang, Jing Wang, Jing Wang, Wenhui Deng, Wenhui Deng, Wenhui Deng, Qing Lv, Qing Lv, Qing Lv, Yuman Li, Yuman Li, Yuman Li, Tianshu Liu, Tianshu Liu, Tianshu Liu, Mingxing Xie, Mingxing Xie, Mingxing Xie   +17 more
doaj   +1 more source

Molecular and Genetic Insights into Thoracic Aortic Dilation in Conotruncal Heart Defects [PDF]

, 2016
Thoracic aortic dilation (AD) has commonly been described in conotruncal defects (CTDs), such as tetralogy of Fallot, double outlet right ventricle and transposition of the great arteries, and truncus arteriosus.
Kay, W. Aaron
core   +2 more sources

Surgical management of the aortic arch in patients with inherited aortopathy

Frontiers in Cardiovascular Medicine, 2022
Surgical management of the aortic root and ascending aorta has seen an evolution over the past 50 years. Despite the widely available guidelines for management of the aortic root and ascending aorta, including in those with connective tissue disease and ...
Gianluca Lucchese, Rajdeep Bilkhu
doaj   +1 more source

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]

, 2017
Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa, Barnette, Basalyga, Bonow, Brown-Augsburger, Brunskill, Brunskill, Chung, Fondard, Franco, Gallegos, Gapski, Ghosh, Gu, Helske, Hinton, Hinton, Holm, Ihn, Iverson, Jensen, Keane, Krenz, Liang, Lindeman, Marshall, Mercer, Mohler, Mozaffarian, Munjal, Nishimura, Nkomo, Perrotta, Poggio, Potter, Rajamannan, Rossebo, Sauls, Schmieder, Schoen, Starcher, Vesely, Wirrig, Wylie-Sears, Xiong, Xiong   +45 more
core   +2 more sources

Obstetric considerations for aortopathy in pregnancy

Annals of Cardiothoracic Surgery, 2023
Aortic dissection (AD) associated with pregnancy can have catastrophic consequences for the mother and/or fetus. AD occurs in 4-5 per 1,000,000 pregnancies and, despite its rarity, is the third most frequent maternal cardiovascular cause of death. AD associated with pregnancy is most likely to occur in the third trimester or postpartum period.
Whelan, Anna R., Ringel, Myles E., Shalhub, Sherene, Russo, Melissa L.   +3 more
openaire   +2 more sources

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Implications of Bicuspid Aortic Valve Disease and Aortic Stenosis/Insufficiency as Risk Factors for Thoracic Aortic Aneurysm

Reviews in Cardiovascular Medicine, 2023
Bicuspid Aortic Valves (BAV) are associated with an increased incidence of thoracic aortic aneurysms (TAA). TAA are a common aortic pathology characterized by enlargement of the aortic root and/or ascending aorta, and may become life threatening when ...
Habib Jabagi, Dov Levine, Lara Gharibeh, Chiara Camillo, Estibaliz Castillero, Giovanni Ferrari, Hiroo Takayama, Juan B. Grau   +7 more
doaj   +1 more source

Knuckle, Knuckle, Dimple, Dimple: Do Not Miss A Diagnostic Opportunity

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Archibald's metacarpal sign is characterized by dimpling over the knuckles when the fist is clenched, resulting from relative shortening of the fourth and fifth metacarpals compared with the third. ABSTRACT Turner syndrome (TS) often presents with subtle or overlooked clinical signs, contributing to frequent diagnostic delays. We describe the case of a
Maria Chiara Pellegrin, Gianluca Tamaro, Alice Fachin, Egidio Barbi, Gianluca Tornese   +4 more
wiley   +1 more source