Results 61 to 70 of about 17,467 (186)

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve

Nature Communications
Bicuspid aortic valve, a prevalent congenital malformation, predisposes individuals to severe complications. Although the condition exhibits substantial heritability, known protein-coding and common regulatory mutations explain a minority of cases.
Artemy Zhigulev, Andrey Buyan, Enikő Lázár, Nikita Gryzunov, Karin Lång, Raphaël Mauron, Vladimir Nozdrin, Rapolas Spalinskas, Sailendra Pradhananga, Madeleine Petersson Sjögren, Doreen Schwochow, Anders Franco-Cereceda, Joakim Lundeberg, Ivan V. Kulakovskiy, Per Eriksson, Hanna M. Björck, Pelin Sahlén   +16 more
doaj   +1 more source

Relation of Bicuspid Aortic Valve Morphology to the Dilatation Pattern of the Proximal Aorta: Focus on the Transvalvular Flow

Cardiology Research and Practice, 2012
Whether the dilatation of proximal aorta in patients with bicuspid aortic valve is secondary to hemodynamic effects related to the abnormal aortic valve or a primary manifestation of the genetic disorder remains controversial.
Evaldas Girdauskas, Kushtrim Disha, Michael-Andrew Borger, Thomas Kuntze   +3 more
doaj   +1 more source

Quantitative collagen and proteoglycan imaging reveal organic layering, gradients and regional texture in young mature dental cementum

VIEW, EarlyView.
Cementum, the mineralized tissue covering all mammalian tooth roots, helps maintain tooth stability, but its internal organization is still poorly understood. In this study, we combine quantitative histologial methods to map the regional distributions of collagen fibers and proteoglycan‐rich matrix layers in porcine cementum.
Jie Zhen, Yuyang Mao, Hamza Elfarraj, Paul Zaslansky   +3 more
wiley   +1 more source

Bicuspid aortic valve in pregnancy

Taiwanese Journal of Obstetrics and Gynecology, 2014
The outcomes in pregnant patients with bicuspid aortic valves (BAVs) are rarely reported, despite the potentially critical nature of the condition. The aim of this study is to present the clinical complications of BAV in pregnancy.A MEDLINE database search and a Google internet search were conducted to find literature on BAV in pregnancy published ...
openaire   +3 more sources

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

eLife, 2018
Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the ...
Lorriane Eley, Ahlam MS Alqahtani, Donal MacGrogan, Rachel V Richardson, Lindsay Murphy, Alejandro Salguero-Jimenez, Marcos Sintes Rodriguez San Pedro, Shindi Tiurma, Lauren McCutcheon, Adam Gilmore, José Luis de La Pompa, Bill Chaudhry, Deborah J Henderson   +12 more
doaj   +1 more source

Multiple cardiac malformations in a calf

Australian Veterinary Journal, EarlyView.
This paper describes the morphopathological aspects of a case of multiple cardiac malformations in a calf. A two‐day‐old male calf of undefined breed was born with an ectopic heart, presenting with dyspnoea and in lateral recumbency. The owner had repositioned the exposed heart beneath the adjacent skin, which was suclosed, without additional incisions
LA Soares, IC Matias, DRS Garcia, HS Oliveira Filho, SM Figueiredo, GX Medeiros, LÂ Maia, GJN de Galiza   +7 more
wiley   +1 more source

Prevalence of peripheral dental caries and diastemata in horses fed high‐carbohydrate diets

Equine Veterinary Education, EarlyView.
Summary Background Peripheral dental caries and diastemata impair equine oral health. Diets rich in soluble carbohydrates are suspected risk factors, but few studies have assessed their impact. In Brazil, sugarcane is widely used as a forage source due to its availability and low cost.
S. L. Paredes, R. P. Mendes, M. D. Lacerenza, R. G. S. Dória, J. d. A. Arantes, L. S. B. Silva, R. R. Corrêa   +6 more
wiley   +1 more source

P4.03 APOPTOSIS IN THE MEDIA OF THE AORTIC WALL AND ITS RELATIONSHIP WITH AORTIC VALVE MORPHOLOGY IN AORTIC DILATATION

Artery Research, 2013
Background: The aortic valve is normally tricuspid but may vary in that it can be made up of 1, 2 or 4 leaflets with each of these often associated with aortopathy, most commonly aortic dilatation.
H. Edwards, J. Dargan, L. Elliot, A. Modi, S. Ohri, P. Townsend   +5 more
doaj   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source