Results 81 to 90 of about 29,296 (236)

Relation of Bicuspid Aortic Valve Morphology to the Dilatation Pattern of the Proximal Aorta: Focus on the Transvalvular Flow

Cardiology Research and Practice, 2012
Whether the dilatation of proximal aorta in patients with bicuspid aortic valve is secondary to hemodynamic effects related to the abnormal aortic valve or a primary manifestation of the genetic disorder remains controversial.
Evaldas Girdauskas, Kushtrim Disha, Michael-Andrew Borger, Thomas Kuntze   +3 more
doaj   +1 more source

Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve [PDF]

, 2014
BACKGROUND: Bicuspid aortic valve (BAV) is the most common type of congenital heart disease with a population prevalence of 1-2%. While BAV is known to be highly heritable, mutations in single genes (such as GATA5 and NOTCH1) have been reported in few ...
David Newsom, Don Corsmeier, Elizabeth M Bonachea, Gloria Zender, Kim L McBride, Peter White, Sara Fitzgerald-Butt, Vidu Garg   +7 more
core   +2 more sources

Valve-preserving surgery on the bicuspid aortic valve [PDF]

European Journal of Cardio-Thoracic Surgery, 2013
Valve repair has emerged as an important intervention for the management of bicuspid aortic valve disease. This systematic review aims to assess the safety, efficacy and durability of bicuspid aortic valve repair. Initial searches yielded 682 abstracts, reduced by de-duplication to 370, of which 56 full papers were accessed and 30 met the inclusion ...
Vohra, Hunaid, Whistance, Robert N, de Kerchove, Laurent, Punjabi, Prakash, El Khoury, Gebrine   +4 more
openaire   +3 more sources

Increased calcification by erythrophagocytosis in aortic valvular interstitial cells

ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin, Magnus Bäck, Anders Franco‐Cereceda, Sven‐Christian Pawelzik   +3 more
wiley   +1 more source

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

eLife, 2018
Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the ...
Lorriane Eley, Ahlam MS Alqahtani, Donal MacGrogan, Rachel V Richardson, Lindsay Murphy, Alejandro Salguero-Jimenez, Marcos Sintes Rodriguez San Pedro, Shindi Tiurma, Lauren McCutcheon, Adam Gilmore, José Luis de La Pompa, Bill Chaudhry, Deborah J Henderson   +12 more
doaj   +1 more source

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta [PDF]

, 2019
Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation ...
Ha, H, Kim, G.B, Kim, N, Kim, Y.-H, Kweon, J, Lee, S.J, Yang, D.H.   +6 more
core   +1 more source

Longitudinal 4D Flow MRI‐Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background 4D flow MRI‐derived parameters such as wall shear stress (WSS) may improve abdominal aortic aneurysm (AAA) progression prediction. Validation of this biomarker is needed, but longitudinal data are lacking. Purpose Investigate longitudinal WSS changes and associations with AAA morphology. Study Type Prospective.
E. Aalbregt, W. Stehling, E. M. Schrauben, J. van Schuppen, L. J. Meijboom, R. A. P. Takx, A. J. Nederveen, P. van Ooij, V. Jongkind, K. K. Yeung   +9 more
wiley   +1 more source

Risk factors for paravalvular leak after transcatheter aortic valve replacement [PDF]

, 2019
Objective. To assess risk factors for paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) in a large single-center cohort, including measurement of aortic valve calcification using a reproducible method. Methods.
Pollari, Francesco
core  

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

P4.03 APOPTOSIS IN THE MEDIA OF THE AORTIC WALL AND ITS RELATIONSHIP WITH AORTIC VALVE MORPHOLOGY IN AORTIC DILATATION

Artery Research, 2013
Background: The aortic valve is normally tricuspid but may vary in that it can be made up of 1, 2 or 4 leaflets with each of these often associated with aortopathy, most commonly aortic dilatation.
H. Edwards, J. Dargan, L. Elliot, A. Modi, S. Ohri, P. Townsend   +5 more
doaj   +1 more source