Results 81 to 90 of about 34,124 (288)

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

eLife, 2018
Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the ...
Lorriane Eley, Ahlam MS Alqahtani, Donal MacGrogan, Rachel V Richardson, Lindsay Murphy, Alejandro Salguero-Jimenez, Marcos Sintes Rodriguez San Pedro, Shindi Tiurma, Lauren McCutcheon, Adam Gilmore, José Luis de La Pompa, Bill Chaudhry, Deborah J Henderson   +12 more
doaj   +1 more source

Valve-preserving surgery on the bicuspid aortic valve [PDF]

European Journal of Cardio-Thoracic Surgery, 2013
Valve repair has emerged as an important intervention for the management of bicuspid aortic valve disease. This systematic review aims to assess the safety, efficacy and durability of bicuspid aortic valve repair. Initial searches yielded 682 abstracts, reduced by de-duplication to 370, of which 56 full papers were accessed and 30 met the inclusion ...
Vohra, Hunaid, Whistance, Robert N, de Kerchove, Laurent, Punjabi, Prakash, El Khoury, Gebrine   +4 more
openaire   +3 more sources

Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22–23 Deletions

Clinical Genetics, EarlyView.
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson, Daniel E. McGinn, T. Blaine Crowley, Lydia Rockart, Audrey Green, Victoria Giunta, Oanh Tran, Daniella Miller, Jeroen Breckpot, Ann Swillen, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Federica Pulvirenti, Bruno Marino, Beverly S. Emanuel, Elaine H. Zackai, Zhengdong D. Zhang, Elizabeth Goldmuntz, Erik Boot, Anne S. Bassett, Bernice E. Morrow, Donna M. McDonald‐McGinn   +22 more
wiley   +1 more source

Risk factors for paravalvular leak after transcatheter aortic valve replacement [PDF]

, 2019
Objective. To assess risk factors for paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) in a large single-center cohort, including measurement of aortic valve calcification using a reproducible method. Methods.
Pollari, Francesco
core  

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. [PDF]

, 2015
The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life.
Andrews, WD, Mommersteeg, MT, Parnavelas, JG, Yeh, ML   +3 more
core   +1 more source

Geometric characteristics of bicuspid aortic valves [PDF]

, 2021
Jan Nijs, Babs Vangelder, Kaoru Tanaka, Sandro Gelsomino, Ines Van Loo, Mark La Meir, Jos G. Maessen, Bas Kietselaer   +7 more
openalex   +1 more source

Long‐Term Follow‐Up of Radiofrequency Slow Pathway Ablation for Atrioventricular Nodal Re‐Entrant Tachycardia: Late Outcomes

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Slow pathway radiofrequency ablation is an effective treatment for atrioventricular nodal re‐entrant tachycardia (AVNRT) but has been reported in some series to result in late atrioventricular block. We examined our local experience with a retrospective review. Methods A retrospective review of all patients undergoing slow pathway
Emma Yaakop, Stephen Browitt, Catherine Cruickshank, Judy Greenslade, Iain Melton, Matthew Daly, Geoffrey Clare, Ross Downey, Daniel Garofalo, Ian Crozier   +9 more
wiley   +1 more source

A very rare case of late diagnosis of cor triatriatum sinistrum [PDF]

, 2018
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Czerny, Martin, Jurko, Alexander, Minarik, Milan, Schusterova, Ingrid   +3 more
core   +1 more source