Results 81 to 90 of about 2,920 (220)

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells [PDF]

, 2017
The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been suggested as a potential molecular target for anti-melanoma therapeutics. However, few JAK2 inhibitors were being tested for melanoma therapy.
Chen, XP, Chiu, P, Dong, ZZ, Han, QB, Huang, JM, Kwong, DWJ, Leung, CH, Lu, JJ, Ma, DL, Vellaisamy, K, Wu, KJ, Zhong, HJ   +11 more
core   +2 more sources

Staphylococcus aureus AgrA Modulators From South African Antimicrobial Plants

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
The study workflow utilized validated in silico [molecular docking, fingerprinting, pharmacokinetics prediction, molecular dynamics (MD) simulation, ligand‐protein contact maps] tools to bioprospect a wide variety of metabolites surveyed from South African plants with antimicrobial activities, and target them against the key S.
Christiana Eleojo Aruwa, Saheed Sabiu
wiley   +1 more source

Torreya grandis Seed Polyphenols Protect RAW264.7 Macrophages by Inhibiting Oxidative Stress and Inflammation

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Torreya grandis seed polyphenols (TGSP), primarily containing gallic acid and epicatechin, exhibit selective free radical scavenging activity. TGSP pretreatment effectively inhibits LPS‐induced inflammatory responses by reducing TNF‐α, NO, and IL‐6 production. TGSP also alleviates H2O2‐induced oxidative stress by enhancing antioxidant enzyme activities
Ran Liu, Baogang Zhou, Kundian Che, Wei Gao, Haoyuan Luo, Jialin Yang, Zhanjun Chen, Wenzhong Hu   +7 more
wiley   +1 more source

Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells [PDF]

, 2007
Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic properties, but traditionally Hp was also used to treat inflammation.
Birt, Diane, Birt, Diane, Delate, Kathleen, Dixon, Philip, Hammer, Kimberly, Hillwig, Matthew, Murphy, Patricia, Solco, Avery, Wurtele, Eve, Wurtele, Eve   +9 more
core   +3 more sources

Visible‐Light Photocatalysis for Sustainable Chromene Synthesis and Functionalization

Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.
Visible‐light photocatalysis provides sustainable and versatile methods for the synthesis and functionalization of chromene derivatives. This review compiles cutting‐edge methodologies, highlighting transformations such as multicomponent reactions, cross‐dehydrogenative coupling reactions, diverse cascade processes, and Giese‐type additions.
Paula Pérez‐Ramos, Georgia Biniari, Raquel G. Soengas, Humberto Rodríguez‐Solla, Carmen Simal   +4 more
wiley   +1 more source

A New Optical Biflavonoid, (2″)-2″,3″-Dihydrorobustaflavone 7,4′-Dimethyl Ether, and Other Constituents from Alsto

Natural Product Communications, 2019
A new optical biflavonoid, (2” R )-2″,3″-dihydrorobustaflavone 7,4′-dimethyl ether ( 1 ), and 6 known compounds ( 2-7 ) were isolated for the first time from the 70% ethanol extract of Selaginella trichoclada Alsto.
Peng Yang, Mei-Long Lu, Ke Li, Qun Zhou   +3 more
doaj   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source

Globulixanthone F, a New Polyoxygenated Xanthone with an Isoprenoid Group and Two Antimicrobial Biflavonoids from the Stem Bark of

Natural Product Communications, 2009
Bioassay-guided fractionation of the stem bark of Symphonia globulifera has yielded three known xanthones, ugaxanthone (1), mbarraxanthone (2) and gentisein (3), two biflavonoid derivatives named GB2 (4) and manniflavanone GB3 (5), and one new ...
Pierre Mkounga, Zacharias T. Fomum, Michèle Meyer, Bernard Bodo, Augustin E. Nkengfack   +4 more
doaj   +1 more source

Biflavonoids from Stellera chamaejasme

Pharmaceutical Biology, 2003
Five biflavonoids (wilstrol A, wikstrol B, neochamaejasmin A, neochamaejasmin B and chamajssmine) were isolated from the roots of Stellera chamaejasme L. These compounds play a very important role in the chemotaxonomy of Thymelaeaceae.
Baomin Feng, Yuehu Pei, Huiming Hua, Tao Wang, Yi Zhang   +4 more
openaire   +1 more source

A New Ceramide and Biflavonoid from the Leaves of (Chrysobalanaceae)

Natural Product Communications, 2016
A new ceramide and a new biflavonoid named parinaramide ( 1 ) and sparinaritin ( 2 ), respectively, have been isolated along with ten known compounds, kaempferol, quercetin, taxifolin, taxifolin-3- O -rhamnoside, lupeol, betulinic acid, ursolic acid, 2α ...
Martial F. E. Adjapmoh, Flavien A. A. Toze, Jules L. Songue, Moses K. Langat, Gilbert D. W. F. Kapche, Abdul Hameed, Mehreen Lateef, Muhammad A. Shaiq, Luc M. Mbaze, Jean D. Wansi, Alain F. W. Kamdem   +10 more
doaj   +1 more source