Selaginella extracts extend lifespan and mitigate oxidative stress in Caenorhabditis elegans [PDF]
Frontiers in PharmacologyIntroductionSelaginella species hold a traditional place in medicine and cosmetics, but their potential to extend lifespan and the underlying bioactive compounds remain inadequately investigated.
Xueqing Chen +15 more
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Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer [PDF]
Discover OncologyBackgrounds Pancreatic cancer is one of the most common malignancies in the gastrointestinal system, notorious for its high malignancy and low survival rate.
Xu He +8 more
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Frontiers in Cellular and Infection Microbiology, 2021 Treatment of leishmaniasis is a challenging subject. Although available, chemotherapy is limited, presenting toxicity and adverse effects. New drugs with antileishmanial activity are being investigated, such as antiparasitic compounds derived from plants.
Daiana de Jesús Hardoim +2 more
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New Insights on Structures Forming the Lignin-Like Fractions of Ancestral Plants [PDF]
Frontiers in Plant Science, 2021 In the present work, lignin-like fractions were isolated from several ancestral plants –including moss (Hypnum cupressiforme and Polytrichum commune), lycophyte (Selaginella kraussiana), horsetail (Equisetum palustre), fern (Nephrolepis cordifolia and ...
Jorge Rencoret +9 more
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Amentoflavone Inhibits HSV-1 and ACV-Resistant Strain Infection by Suppressing Viral Early Infection
Viruses, 2019 Infection of Herpes simplex virus 1 (HSV-1) induces severe clinical disorders, such as herpes simplex encephalitis and keratitis. Acyclovir (ACV) is the current therapeutic drug against viral infection and ACV-resistant strains have gradually emerged ...
Kai Zheng, Yifei Wang, Kai Zheng
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Molecules, 2017 Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence ...
Sheng Yu, Hui Yan, Li Zhang
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Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase [PDF]
HeliyonThe SARS-CoV-2 pandemic caused millions of deaths due to its prominent infectivity and mortality. Although the vaccines and medicines for SARS-CoV-2 are on the market, new coronavirus variants like influenza are expected to reemerge continuously ...
Kyoung Won Youn +7 more
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Amentoflavone protects against cisplatin-induced acute kidney injury by modulating Nrf2-mediated oxidative stress and ferroptosis and partially by activating Nrf2-dependent PANoptosis [PDF]
Frontiers in PharmacologyBackgroundCisplatin is a widely used drug for the treatment of solid organ cancer, but its renal toxicity cannot be ignored. Amentoflavone (AME), a natural flavonoid compound, has remarkable pharmacological effects, including anti-inflammatory and ...
Yan Zhang +4 more
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Drug Delivery, 2020 Amentoflavone (AMF) is a kind of biflavonoids existing in Ginkgo biloba leaves. It has many biological activities, such as antioxidant, anti-inflammatory, anti-bacterial, antiviral, hypoglycemic, anti-tumor and inducing apoptosis. However, its solubility
Xue Feng, Luya Li, Yuqian Zhang
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3′-8″- Biflavones: A Review of Their Structural Diversity, Natural Occurrence, Role in Plants, Extraction and Identification [PDF]
MoleculesDimeric forms of flavonoids, known as biflavonoids, are much less studied compared to monomeric forms. It is estimated that nearly 600 different natural biflavonoids have been described to date, containing various subtypes that can be subdivided ...
Dunja Šamec +5 more
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