Isolation and Activity of Two Antibacterial Biflavonoids from Leaf Extracts of (Clusiaceae)
Natural Product Communications, 2009 The antibacterial activity of the acetone extract of Garcinia livingstonei leaves was studied using bioautography and by determining the minimum antibacterial concentration against four nosocomial pathogens.
Adamu A. Kaikabo +2 more
doaj +1 more source
Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP [PDF]
, 2017 We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Abovich +51 more
core +5 more sources
Molecules, 2021 The potential biological activities of Viburnum stellato-tomentosum (VS), a plant mainly found in Costa Rica, have yet to be reported. Supplementation of VS extract for 17 weeks significantly decreased body weight gain, fat weight, fasting glucose ...
Seona Cho +10 more
doaj +1 more source
Potential of amentoflavone with antiviral properties in COVID-19 treatment [PDF]
Asian Biomedicine, 2021 AbstractAmentoflavone is one of the flavonoids that are known for their antiviral effects and many of them are predicted to have inhibitory effects against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome Coronavirus (MERS-CoV) enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro ...
openaire +2 more sources
Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders. [PDF]
Front PharmacolAmentoflavone (AME) is a flavonoid compound found in over 120 plants. Its extensive pharmacological activity for treating cardiocerebrovascular diseases and neurological disorders have attracted the attention of researchers in recent years. However, owing to the poor solubility and low bioavailability of AME, it has not been developed as a drug for ...
Zhang H +5 more
europepmc +4 more sources
Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana [PDF]
, 2015 Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3′,4′-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D ...
Bochet, Christian G. +6 more
core +2 more sources
Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. [PDF]
, 2017 Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity.
Ashour, M.E. +4 more
core +1 more source
Potential cardioprotective effects of Amentoflavone in doxorubicin-induced cardiotoxicity in mice
Biomedicine & Pharmacotherapy, 2022 Doxorubicin (DOX) is an available chemotherapeutic drug for treating various tumors. However, its effectiveness is limited by cardiotoxicity. Amentoflavone (AMF), a natural biflavonoid separated from Cycas thouarsii ethyl acetate fraction, displays promising anticancer, anti-inflammatory, and antioxidant effects.
Fatemah A, Alherz +3 more
openaire +2 more sources
Biomolecules, 2018 Flavonoids are widely recognized as natural polydrugs, given their anti-inflammatory, antioxidant, sedative, and antineoplastic activities. Recently, different studies showed that flavonoids have the potential to inhibit bromodomain and extraterminal ...
Fernando D. Prieto-Martínez +1 more
doaj +1 more source
Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells [PDF]
, 2007 Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic properties, but traditionally Hp was also used to treat inflammation.
Birt, Diane +9 more
core +3 more sources