Neuroprotective Potential of Biflavone Ginkgetin: A Review [PDF]
Life, 2023 Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results.
Hari Prasad Devkota +2 more
exaly +4 more sources
Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy [PDF]
Natural Products and BioprospectingThe extraction of anticancer agents from medicinal plants represents a highly promising research frontier. Ginkgetin, a natural biflavone, is one of the effective pharmacological components of Ginkgo biloba leaves (GBLs).
Jin-Jian Lu +2 more
exaly +3 more sources
Beneficial effects of ginkgetin on improving nonalcoholic steatohepatitis characterized by bulk and single-cell RNA sequencing analysis [PDF]
Frontiers in Pharmacology, 2023 Background and aims: Nonalcoholic steatohepatitis (NASH) has become one of the major causes of cirrhosis and liver failure. However, there are currently no approved medications for managing NASH.
Chaoyang Wang +8 more
doaj +2 more sources
A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
doaj +2 more sources
Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway [PDF]
Frontiers in Pharmacology, 2023 Introduction: Lung cancer, one of the most frequent malignancies, has a high death rate and an increased number of new cases globally. Ginkgo biloba has been used for many years in the treatment of lung cancer.
Kaile Liu +5 more
doaj +2 more sources
Ginkgetin attenuates bone loss in OVX mice by inhibiting the NF-κB/IκBα signaling pathway [PDF]
PeerJBackground Osteoporosis is a disease associated with bone resorption, characterized primarily by the excessive activation of osteoclasts. Ginkgetin is a compound purified from natural ginkgo leaves which has various biological properties, including anti ...
GeJin Wei +5 more
doaj +3 more sources
Ginkgetin: A Promising Multitarget Agent for Diverse Diseases [PDF]
BiomoleculesGinkgetin (GK) is a naturally occurring biflavonoid predominantly isolated from Ginkgo biloba and has attracted increasing attention because of its broad pharmacological activities.
Zhitong Sun +4 more
doaj +2 more sources
Evaluating ginkgetin from Ginkgo biloba as a novel agent for sleep promotion through molecular docking and in vivostudies [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Sleep impacts the well-being and quality of life of millions. Given conventional pharmacotherapy’s limitations and side effects, the quest for adequate and proper sleep promotion is imperative.
Mir Behrad Aghazadeh Ghadim +4 more
doaj +2 more sources
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING [PDF]
Advanced ScienceGinkgo biloba extract is reported to have therapeutic effects on aging‐related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown.
Yadan Liu +16 more
doaj +2 more sources
Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas +2 more
doaj +2 more sources