Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy [PDF]
Natural Products and BioprospectingThe extraction of anticancer agents from medicinal plants represents a highly promising research frontier. Ginkgetin, a natural biflavone, is one of the effective pharmacological components of Ginkgo biloba leaves (GBLs).
Jinjian Lu, Mingqing Huang
exaly +3 more sources
Neuroprotective Potential of Biflavone Ginkgetin: A Review
Life, 2023 Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results.
Gokhan Zengin +2 more
exaly +3 more sources
Ginkgetin enhances the antitumor effect of Taxol on human breast cancer MCF-7 cells via ferroptosis mediated by the MDM2–p53–YAP1 axis [PDF]
Scientific ReportsGinkgetin, a biflavone isolated from Ginkgo biloba, is a potent Wnt signaling inhibitor that can enhance the pharmacological effects of cisplatin on non-small cell lung cancer (NSCLC) by activating the ferroptosis pathway.
Guangchao Li +4 more
doaj +2 more sources
Beneficial effects of ginkgetin on improving nonalcoholic steatohepatitis characterized by bulk and single-cell RNA sequencing analysis [PDF]
Frontiers in Pharmacology, 2023 Background and aims: Nonalcoholic steatohepatitis (NASH) has become one of the major causes of cirrhosis and liver failure. However, there are currently no approved medications for managing NASH.
Chaoyang Wang +8 more
doaj +2 more sources
STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells [PDF]
HereditasBackground Bladder cancer remains a major urologic malignancy with substantial recurrence and progression risk, underscoring the need for mechanism-informed therapeutic candidates.
Pengze Wu +7 more
doaj +2 more sources
A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
doaj +2 more sources
Ginkgetin: A Promising Multitarget Agent for Diverse Diseases [PDF]
BiomoleculesGinkgetin (GK) is a naturally occurring biflavonoid predominantly isolated from Ginkgo biloba and has attracted increasing attention because of its broad pharmacological activities.
Zhitong Sun +4 more
doaj +2 more sources
Ginkgetin attenuates bone loss in OVX mice by inhibiting the NF-κB/IκBα signaling pathway [PDF]
PeerJBackground Osteoporosis is a disease associated with bone resorption, characterized primarily by the excessive activation of osteoclasts. Ginkgetin is a compound purified from natural ginkgo leaves which has various biological properties, including anti ...
GeJin Wei +5 more
doaj +3 more sources
High-performance liquid chromatography – diode array detection method validation for amentoflavone-type biflavonoids in five Encephalartos species with potential neuroprotective activity [PDF]
Scientific ReportsGinkgo biloba is a well-known food supplement for enhancing memory and is rich in biflavonoids. Biflavonoids are predominant in the Order Cycadales (cycads). Among cycads, five Encephalartos species, E. ferox, E. kisambo, E. laurentianus, E.
Zainab G. El-Natory +4 more
doaj +2 more sources
Evaluating ginkgetin from Ginkgo biloba as a novel agent for sleep promotion through molecular docking and in vivostudies [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Sleep impacts the well-being and quality of life of millions. Given conventional pharmacotherapy’s limitations and side effects, the quest for adequate and proper sleep promotion is imperative.
Mir Behrad Aghazadeh Ghadim +4 more
doaj +2 more sources