Results 11 to 20 of about 1,142 (187)

Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects [PDF]

Journal of Inflammation Research
Han Li,1,* Dongsheng Wei,2,* Huimin Cao,2 Yelei Han,1 Luzhen Li,1 Yuting Liu,1 Jiajie Qi,1 Xinyue Wu,1 Zhe Zhang2,3 1The First School of Clinical Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic ...
Li H, Wei D, Cao H, Han Y, Li L, Liu Y, Qi J, Wu X, Zhang Z   +8 more
doaj   +5 more sources

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways [PDF]

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is considered an advancing chronic degenerative joint disease, leading to severe physical functional impairment of patients. Its development is closely related to increased inflammation and oxidative stress within the joint.
Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu   +5 more
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Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy. Ginkgetin effectively treats several carcinoma cells. However, little is known about effects of Ginkgetin on RCC.
Yu Ren, Shuang-shuang Huang, Xue Wang, Zhong-guan Lou, Xu-ping Yao, Guo-bin Weng   +5 more
doaj   +3 more sources

3′-8″- Biflavones: A Review of Their Structural Diversity, Natural Occurrence, Role in Plants, Extraction and Identification [PDF]

Molecules
Dimeric forms of flavonoids, known as biflavonoids, are much less studied compared to monomeric forms. It is estimated that nearly 600 different natural biflavonoids have been described to date, containing various subtypes that can be subdivided ...
Dunja Šamec, Iva Jurčević Šangut, Erna Karalija, Bojan Šarkanj, Bruno Zelić, Anita Šalić   +5 more
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A Comparative Molecular Dynamics Study of Food-Derived Compounds as PD-L1 Inhibitors: Insights Across Six Flavonoid Subgroups [PDF]

Molecules
In this study, we investigated the inhibitory potential of 60 flavonoids from six distinct subgroups on the programmed cell death ligand 1 (PD-L1) dimer through molecular docking and dynamics simulations.
Dejun Jiang, Hyuk-Ku Kwon, Oh Wook Kwon, Youngjin Choi   +3 more
doaj   +2 more sources

Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: In silico and in vitro approaches [PDF]

Current Research in Structural Biology
Nowadays, one of the methods to prevent the progress of Alzheimer's disease (AD) is to prescribe compounds that inhibit the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Researchers are actively pursuing compounds, particularly of
Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliaei   +3 more
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Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds [PDF]

Scientific Reports
Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition that encompasses ulcerative colitis (UC) and Crohn’s disease (CD). Targeting both inflammation and the epithelial barrier simultaneously can significantly improve symptom management
Pardis Mansouri, Pegah Mansouri, Sohrab Najafipour, Seyed Amin Kouhpayeh, Akbar Farjadfar, Esmaeil Behmard   +5 more
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(aS)-Glucosciadopitysin, a New Biflavonoid Glycoside from the Leaves of Ginkgo biloba and Osteogenic Activity of Bioflavonoids [PDF]

Plants
The leaves of Ginkgo biloba have been used in treating freckles and effectively reducing cough and sputum in folk medicines. Recently, investigations into the correlation between ginkgo leaves and the proliferative activity of osteogenic differentiation ...
Se Yun Jeong, Kwang Ho Lee, Seon Hee Kim, Min Hye Yang, Gakyung Lee, Ki Hyun Kim   +5 more
doaj   +2 more sources

In-silico study for the identification of potential destabilizers between the spike protein of SARS-CoV-2 and human ACE-2 [PDF]

Informatics in Medicine Unlocked, 2023
The emergence of the new SARS-CoV-2 virus, which causes the disease known as COVID-19, has generated a pandemic that has plunged the world into a health crisis. The infection process is triggered by the direct binding of the receptor-binding domain (RBD)
Jeffry Medina-Barandica, Neyder Contreras-Puentes, Arnulfo Tarón-Dunoyer, Marlene Durán-Lengua, Antistio Alviz-Amador   +4 more
doaj   +2 more sources

A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage [PDF]

International Journal of Nanomedicine
Tian Yun,1,2,* Dan Hou,2,* Yujie Hu,2 Yonghao Fan,3 Shun Zhang,4 Tiantian Wu,1,4 Yong You1 1Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, People’s Republic of China; 2Department of neurology,
Yun T, Hou D, Hu Y, Fan Y, Zhang S, Wu T, You Y   +6 more
doaj   +2 more sources