Results 21 to 30 of about 751 (112)

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways [PDF]

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is considered an advancing chronic degenerative joint disease, leading to severe physical functional impairment of patients. Its development is closely related to increased inflammation and oxidative stress within the joint.
Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu   +5 more
doaj   +2 more sources

ROS-responsive, brain- and M1 microglia-targeting modified ginkgetin-loaded smart liposomes ameliorate cerebral ischemia by HIF-1α-mediated negative regulation of microglia pyroptosis [PDF]

Materials Today Bio
Ischemic stroke triggers a cascade of mitochondrial dysfunction, oxidative stress, neuroinflammation, and pyroptosis, ultimately leading to neuronal injury and neurological deficits. Therapeutic efficacy is often limited by inadequate blood–brain barrier
Xueyuan Li, Zi Ye, Wenyang Nie, Bao Zhou, Haocheng Qin, Zhijie Zhao, Yilong Fu, Dun Liu, Shaowei Zheng, Liangyu Wang, Jun Ma, Jingying Guo, Beibei Nie, Yan Lu, Dongming Yan, Zhiwen Luo, Qingshan Wang, Meng Bian, Hui Jiang, Di Chen   +19 more
doaj   +2 more sources

Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy. Ginkgetin effectively treats several carcinoma cells. However, little is known about effects of Ginkgetin on RCC.
Yu Ren, Shuang-shuang Huang, Xue Wang, Zhong-guan Lou, Xu-ping Yao, Guo-bin Weng   +5 more
doaj   +1 more source

Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway

Frontiers in Pharmacology, 2023
Introduction: Lung cancer, one of the most frequent malignancies, has a high death rate and an increased number of new cases globally. Ginkgo biloba has been used for many years in the treatment of lung cancer.
Kaile Liu, Xiaojie Fu, Zhongqi Wang, Lian Yang, Jia Yang, Haibin Deng   +5 more
doaj   +1 more source

Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.)

Plants, 2022
Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas, Iva Jurčević, Dunja Šamec   +2 more
doaj   +1 more source

Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes

Scientific Reports, 2021
Atherosclerosis, a chronic inflammatory disease of large arteries, is the major contributor to the growing burden of cardiovascular disease-related mortality and morbidity.
Mazen O. Alharbi, Bidisha Dutta, Rishov Goswami, Shweta Sharma, Kai Y. Lei, Shaik O. Rahaman   +5 more
doaj   +1 more source

Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

Plants, 2022
Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine.
Dunja Šamec, Erna Karalija, Sabina Dahija, Sherif T. S. Hassan   +3 more
doaj   +1 more source

Anti-Biofilm and Antibacterial Activities of Cycas media R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches

Antibiotics, 2022
Enterococcus species possess many virulence factors that have an essential role in exacerbating the infections caused by them. The current study aimed to evaluate the effect of the secondary metabolites ginkgetin (GINK) and sotetsuflavone (SOTE ...
Nashwah G. M. Attallah, Omnia Momtaz Al-Fakhrany, Engy Elekhnawy, Ismail A. Hussein, Moataz A. Shaldam, Najla Altwaijry, Moneerah J. Alqahtani, Walaa A. Negm   +7 more
doaj   +1 more source

A Highly Adaptable Hydrogen Bond Re-Orientation (HyBRO) Strategy for Multiscale Vasculature Fabrication. [PDF]

Adv Mater
A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Liao Z, Liu Y, Chen C, Lei IM, Dong L, Wang C.   +5 more
europepmc   +2 more sources

Green Biosynthesis of Bioactive Streptomyces Metabolites Using Edible Mushrooms: Implications for Glycemic Control and Hepatic Protection in Diabetic Rats. [PDF]

Food Sci Nutr
Mushroom‐mediated Streptomyces metabolites improved fasting blood glucose, reduced hepatic injury markers, restored antioxidant defenses, and showed supportive molecular docking interactions, indicating potential as a functional food or nutraceutical for diabetes‐associated metabolic and liver protection.
Nageye YA, Ali AS, Bello KE.
europepmc   +2 more sources