A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
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Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas +2 more
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Bioactive profiling and evaluation of anti-proliferative and anti-cancerous properties of Shivagutika, an Indian polyherbal formulation synchronizing in vitro and in silico approaches [PDF]
Frontiers in Chemistry, 2023 Shivagutika is a polyherbal formulation mentioned in Ayurveda, the oldest system of medicine. The aim of this study was to investigate the anti-breast cancer potential of DCM extract of Shivagutika using MCF-7, MDA-MB-231, and MDA-MB-468.
Pushpa V. H. +8 more
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Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine.
Dunja Šamec +3 more
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RETRACTED ARTICLE: Sciadopitysin mitigates spermatological and testicular damage instigated by paraquat administration in male albino rats [PDF]
Scientific Reports, 2023 Paraquat (PQ) is a herbicide that has ability to induce testicular toxicity by producing reactive oxygen species (ROS). Sciadopitysin (SPS) is a promising flavonoid that displays multiple pharmacological properties i.e., anti-inflammatory, anti-oxidant ...
Muhammad Umar Ijaz +7 more
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Construction and Manipulation of Serial Gradient Dilution Array on a Microfluidic Slipchip for Screening and Characterizing Inhibitors against Human Pancreatic Lipase [PDF]
Biosensors, 2023 Obesity is one of the foremost public health concerns. Human pancreatic lipase (hPL), a crucial digestive enzyme responsible for the digestion of dietary lipids in humans, has been validated as an important therapeutic target for preventing and treating ...
Junqiang Yang +8 more
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Patterns of Biflavonoid Accumulation in Ginkgo (Ginkgo biloba L.) Leaves from 90 Trees and Their Variation with Age, Gender, and Location [PDF]
PlantsBiflavonoids are dimeric flavonoids recognized for their diverse biological activities and significant pharmacological potential, with ginkgo (Ginkgo biloba L.) serving as a primary natural source.
Dunja Šamec +3 more
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Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1 [PDF]
Frontiers in Pharmacology, 2022 Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang +9 more
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Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 [PDF]
Frontiers in Pharmacology, 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song +14 more
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Seasonal Variation of Polyphenols and Pigments in Ginkgo (Ginkgo biloba L.) Leaves: Focus on 3′,8″-Biflavones [PDF]
PlantsGinkgo (Ginkgo biloba L.) is a widely recognized medicinal plant, often grown as an ornamental species in parks around the world. Its leaves change color from green in spring to yellow in autumn.
Iva Jurčević Šangut, Dunja Šamec
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