Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1 [PDF]
Frontiers in Pharmacology, 2022 Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang +9 more
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Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 [PDF]
Frontiers in Pharmacology, 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song +14 more
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Seasonal Variation of Polyphenols and Pigments in Ginkgo (Ginkgo biloba L.) Leaves: Focus on 3′,8″-Biflavones [PDF]
PlantsGinkgo (Ginkgo biloba L.) is a widely recognized medicinal plant, often grown as an ornamental species in parks around the world. Its leaves change color from green in spring to yellow in autumn.
Iva Jurčević Šangut, Dunja Šamec
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Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds [PDF]
Scientific ReportsInflammatory bowel disease (IBD) is a chronic gastrointestinal condition that encompasses ulcerative colitis (UC) and Crohn’s disease (CD). Targeting both inflammation and the epithelial barrier simultaneously can significantly improve symptom management
Pardis Mansouri +5 more
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YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner [PDF]
JCI InsightRNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is
Yu-Jue Li +6 more
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Antifungal Activities of The Extracts From Some Tropical and Temperate Woods [PDF]
Jurnal Manajemen Hutan Tropika, 2011 Empat flavonoids (Sciadopitysin) (1), Ginkgetin (2), Ishorhamnetin (3), dan Quercetin (4), dua Texanes (Taxinine) (5) dan Taxol (6), dan Phenylisoserine methyl ester (7) dapat diisolasi dari Taxus cuspadata var. nana.
Tata Darma +4 more
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Decreased YB-1 expression denervates brown adipose tissue and contributes to age-related metabolic dysfunction. [PDF]
Cell ProlifIn this study, we found that dysregulated butyrate levels in aging mice decreased YB‐1 expression in the brown adipose tissue (BAT), which aggravates aging‐related BAT dysfunction. Mechanistically, YB‐1 promotes BAT function by facilitating sympathetic innervation via producing Slit2.
Zhou R +7 more
europepmc +2 more sources
Editorial: Pharmacokinetics of herbal medicines and herb-drug interactions. [PDF]
Front Pharmacol, 2022 Jia WW, Lu C, Lin G, Ge GB.
europepmc +3 more sources
Paclitaxel-Containing Extract Exerts Anti-Cancer Activity through Oral Administration in A549-Xenografted BALB/C Nude Mice: Synergistic Effect between Paclitaxel and Flavonoids or Lignoids. [PDF]
Evid Based Complement Alternat Med, 2022 Taxus yunnanensis is a paclitaxel‐containing herb with traditional usage in cancer treatment, and its extract possesses great oral bioavailability of paclitaxel. However, it is elusive whether paclitaxel‐containing extract (HDS‐1) can exert anti‐tumor effect through oral administration and how other components contribute to its efficacy.
Cai D +15 more
europepmc +2 more sources