High-performance liquid chromatography – diode array detection method validation for amentoflavone-type biflavonoids in five Encephalartos species with potential neuroprotective activity [PDF]
Scientific ReportsGinkgo biloba is a well-known food supplement for enhancing memory and is rich in biflavonoids. Biflavonoids are predominant in the Order Cycadales (cycads). Among cycads, five Encephalartos species, E. ferox, E. kisambo, E. laurentianus, E.
Zainab G. El-Natory +4 more
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In silico drug discovery and molecular dynamics simulation for targeting neonatal pneumonia and bronchopulmonary dysplasia [PDF]
Frontiers in ChemistryBackgroundNeonatal pneumonia and bronchopulmonary dysplasia (BPD) are major causes of morbidity and mortality in preterm infants, driven by excessive inflammation involving the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome. This
Xiaoqin Chen, Qian Liu, Bing Zhang
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Applied Sciences (Switzerland), 2019 The coupling of ultrasound and heat⁻reflux extraction (UHRE) was developed for separation for quercetin (QU), kaempferol (KA), ginkgetin (GI) and sciadopitysin (SC) from Mairei Yew leaves.
Chunying Li +2 more
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Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds [PDF]
Scientific ReportsInflammatory bowel disease (IBD) is a chronic gastrointestinal condition that encompasses ulcerative colitis (UC) and Crohn’s disease (CD). Targeting both inflammation and the epithelial barrier simultaneously can significantly improve symptom management
Pardis Mansouri +5 more
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YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner [PDF]
JCI InsightRNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is
Yu-Jue Li +6 more
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Retraction Note: Sciadopitysin mitigates spermatological and testicular damage instigated by paraquat administration in male albino rats [PDF]
Scientific ReportsMuhammad Umar Ijaz +7 more
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Decreased YB-1 expression denervates brown adipose tissue and contributes to age-related metabolic dysfunction. [PDF]
Cell ProlifIn this study, we found that dysregulated butyrate levels in aging mice decreased YB‐1 expression in the brown adipose tissue (BAT), which aggravates aging‐related BAT dysfunction. Mechanistically, YB‐1 promotes BAT function by facilitating sympathetic innervation via producing Slit2.
Zhou R +7 more
europepmc +2 more sources
Network Pharmacology and Bioinformatics Analysis to Identify the Molecular Targets and its Biological Mechanisms of Sciadopitysin against Glioblastoma [PDF]
Journal of CancerHaiwei Lian
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Effect of sciadopitysin on sodium arsenite-induced senescence of rat hippocampal neurons
环境与职业医学, 2022 BackgroundIn addition to the typical signs of skin damage, long-term arsenic exposure is often accompanied by signs and symptoms of neurobehavioral abnormalities.ObjectiveTo investigate potential intervention effect of sciadopitysin on senescence of ...
Cheng CHEN, Xiong CHEN, Aihua ZHANG
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Paclitaxel-Containing Extract Exerts Anti-Cancer Activity through Oral Administration in A549-Xenografted BALB/C Nude Mice: Synergistic Effect between Paclitaxel and Flavonoids or Lignoids. [PDF]
Evid Based Complement Alternat Med, 2022 Taxus yunnanensis is a paclitaxel‐containing herb with traditional usage in cancer treatment, and its extract possesses great oral bioavailability of paclitaxel. However, it is elusive whether paclitaxel‐containing extract (HDS‐1) can exert anti‐tumor effect through oral administration and how other components contribute to its efficacy.
Cai D +15 more
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