Hepatoprotective potential of sciadopitysin against paraquat induced liver damage in rats
Journal of King Saud University - ScienceAnsa Javed +5 more
exaly +2 more sources
TCMD: A High-Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio-Based Resources. [PDF]
Adv Sci (Weinh)This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Xu Y +8 more
europepmc +2 more sources
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 [PDF]
, 2022 COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2 ...
Afladhanti, Putri Mahirah Afladhanti +4 more
core +3 more sources
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach. [PDF]
Molecules, 2020 The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and ...
Augustin TL +3 more
europepmc +3 more sources
Virtual Screening of Natural Compounds Against Six Protein Receptors Coded by The SARS-CoV-2 Genome [PDF]
, 2023 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes Coronavirus 2019 (COVID-19). To date, there has been no proven effective drug for the treatment or prevention of COVID-19.
Awaluddin, Fikry +2 more
core +2 more sources
Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis [PDF]
, 2022 The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally.
AWOLADE, PAUL +5 more
core +2 more sources
Effect of fermentation on the constituents in the branches and leaves of Taxus media and non-small cell lung cancer. [PDF]
Front PharmacolIntroductionNon-small cell lung cancer (NSCLC) is a prominent lung cancer disease worldwide. Currently, commonly used methods, such as surgery and radiotherapy, have significant side effects.
Guo X +8 more
europepmc +3 more sources
Food Science &Nutrition, Volume 11, Issue 6, Page 2925-2941, June 2023., 2023 The physical, chemical, and volatile aroma components were analyzed and identified before and after acaí fermentation, showing an overall increase in these elements. Then, the oxygen radical absorbance capacity (ORAC) values, DPPH free radical scavenging capacity, hydroxyl free radical scavenging capacity, ABTS free radical scavenging capacity, and ...
Wen‐Ying Liu +12 more
wiley +1 more source
Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. [PDF]
Sci AdvNeurotransmitters (NTs) mediate trans-synaptic signaling, and disturbances in their levels are linked to aging and brain disorders. Here, we ascribe an additional function for NTs in mediating intracellular protein aggregation by interaction with ...
Chang X +13 more
europepmc +3 more sources
The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
MedComm, Volume 3, Issue 3, September 2022., 2022 A comprehensive summary of recent advances in SARS‐CoV‐2 3CLpro inhibitors (including marketed drugs, peptidomimetic, and non‐peptidomimetic synthetic compounds, as well as natural compounds and their derivatives), including the inhibitory activities, inhibitory mechanisms, and key structural features, provides new insights for designing and developing
Qing Hu +6 more
wiley +1 more source