Isoginkgetin and Madrasin are poor splicing inhibitors. [PDF]
PLoS ONE, 2023 The production of eukaryotic mRNAs requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation.
Michael Tellier +2 more
doaj +7 more sources
Isoginkgetin—A Natural Compound to Control U87MG Glioblastoma Cell Growth and Migration Activating Apoptosis and Autophagy [PDF]
Molecules, 2022 Isoginkgetin (Iso) is a natural bioflavonoid isolated from the leaves of Ginkgo biloba, this natural substance exhibits many healing properties, among which the antitumor effect stands out.
Massimo Sanchez, Antonietta Arcella
exaly +6 more sources
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy [PDF]
EMBO Molecular MedicineDamaged mitochondria initiate mitochondrial dysfunction-associated senescence, which is considered to be a critical cause for amyotrophic lateral sclerosis (ALS).
Guang Lu, Evandro Fei Fang
exaly +5 more sources
Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells [PDF]
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
John D Stead +2 more
exaly +5 more sources
Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro [PDF]
Viruses, 2021 Foot-and-mouth-disease virus (FMDV) is a picornavirus that causes a highly contagious disease of cloven-hoofed animals resulting in economic losses worldwide. The 3C protease (3Cpro) is the main protease essential in the picornavirus life cycle, which is
Sirin Theerawatanasirikul +2 more
exaly +5 more sources
A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
doaj +2 more sources
Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas +2 more
doaj +2 more sources
First study on in vitro antiviral and virucidal effects of flavonoids against feline infectious peritonitis virus at the early stage of infection [PDF]
Veterinary World, 2023 Background and Aim: Feline infectious peritonitis (FIP), one of the most important infectious diseases in cats is caused by FIP virus (FIPV), a mutated variant of feline coronavirus.
Chanittha Triratapiban +5 more
doaj +2 more sources
Virtual Screening of Soybean Protein Isolate-Binding Phytochemicals and Interaction Characterization [PDF]
Foods, 2023 Soybean protein isolate (SPI) and small molecule interactions have drawn more and more attention regarding their benefits for both parts, while research on large-scale investigations and comparisons of different compounds is absent. In this study, a high
Panhang Liu +3 more
doaj +2 more sources
Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine.
Dunja Šamec +3 more
doaj +2 more sources