Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy [PDF]
EMBO Molecular MedicineDamaged mitochondria initiate mitochondrial dysfunction-associated senescence, which is considered to be a critical cause for amyotrophic lateral sclerosis (ALS).
Miaodan Huang, Han-Ming Shen, Jiahong Lu
exaly +4 more sources
Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro [PDF]
Viruses, 2021 Foot-and-mouth-disease virus (FMDV) is a picornavirus that causes a highly contagious disease of cloven-hoofed animals resulting in economic losses worldwide. The 3C protease (3Cpro) is the main protease essential in the picornavirus life cycle, which is
Porntippa Lekcharoensuk +2 more
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Isoginkgetin and Madrasin are poor splicing inhibitors. [PDF]
PLoS ONEThe production of eukaryotic mRNAs requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation.
Michael Tellier +2 more
doaj +4 more sources
Isoginkgetin—A Natural Compound to Control U87MG Glioblastoma Cell Growth and Migration Activating Apoptosis and Autophagy [PDF]
Molecules, 2022 Isoginkgetin (Iso) is a natural bioflavonoid isolated from the leaves of Ginkgo biloba, this natural substance exhibits many healing properties, among which the antitumor effect stands out.
Antonietta Arcella +2 more
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Isoginkgetin protects chondrocytes and inhibits osteoarthritis through NF-κB and P21 signaling pathway [PDF]
Molecular MedicineObjective Osteoarthritis (OA) is the most prevalent chronic articular disease in adults. The degree of cartilage degradation and matrix depletion in OA have been substantially connected with chondrocyte inflammatory response.
Mengdai Xu +4 more
doaj +3 more sources
3′,8″-Dimerization Enhances the Antioxidant Capacity of Flavonoids: Evidence from Acacetin and Isoginkgetin [PDF]
Molecules, 2019 To probe the effect of 3′,8″-dimerization on antioxidant flavonoids, acacetin and its 3′,8″-dimer isoginkgetin were comparatively analyzed using three antioxidant assays, namely, the ·O2− scavenging assay, the Cu2 ...
Xican Li, Dongfeng Chen, Xiaojian Ouyang
exaly +4 more sources
Pharmacological ResearchLysosomal dysfunction is a core pathological driver of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Transcription factor EB (TFEB) serves as a master regulator of lysosomal biogenesis, and its pharmacological activation ...
Ang Li +13 more
doaj +3 more sources
Correction: Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. [PDF]
PLoS ONE[This corrects the article DOI: 10.1371/journal.pone.0191178.].
Erin van Zyl +4 more
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Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells [PDF]
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl +4 more
doaj +4 more sources
Isoginkgetin increases the expression of metal responsive transcripts but inhibits their translation [PDF]
PLoS ONEClaire Peneycad +3 more
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