Results 21 to 30 of about 801 (163)

Isoginkgetin inhibits lung cancer cell progression through miR-27a-5p/APEX1 axis [PDF]

Tropical Journal of Pharmaceutical Research, 2022
Purpose: To determine the influence of isoginkgetin on the progression of pulmonary carcinogenesis. Methods: A549 cells exposed to isoginkgetin were transfected with miR-27a-5p mimetic and suppressor, as well as short hairpin RNA against apurinic ...
Wu, Langjie, Xu, Li
core   +4 more sources

Mechanisms and efficacy of small molecule latency-promoting agents to inhibit HIV reactivation ex vivo. [PDF]

JCI Insight
Drugs that inhibit HIV transcription and/or reactivation of latent HIV have been proposed as a strategy to reduce HIV-associated immune activation or to achieve a functional cure, yet comparative studies are lacking.
Janssens J, Kim P, Kim SJ, Wedrychowski A, Kadiyala GN, Hunt PW, Deeks SG, Wong JK, Yukl SA.   +8 more
europepmc   +3 more sources

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1 [PDF]

Frontiers in Pharmacology, 2022
Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang, Guang-Hao Zhu, Qi-Hang Zhou, Chun-Zhi Ai, Ya-Di Zhu, Ping Wang, Tong-Yi Dou, Yang-Liu Xia, Hong Ma, Guang-Bo Ge   +9 more
doaj   +2 more sources

Seasonal Variation of Polyphenols and Pigments in Ginkgo (Ginkgo biloba L.) Leaves: Focus on 3′,8″-Biflavones [PDF]

Plants
Ginkgo (Ginkgo biloba L.) is a widely recognized medicinal plant, often grown as an ornamental species in parks around the world. Its leaves change color from green in spring to yellow in autumn.
Iva Jurčević Šangut, Dunja Šamec
doaj   +2 more sources

Phytochemical profile and in vitro evaluation of cassava (Manihot esculenta Crantz) foliage as ruminant feed with/without green banana flour [PDF]

Scientific Reports
Cassava (Manihot esculenta Crantz) is a crucial crop in tropics and subtropics, primarily cultivated for its tuber. However, its foliage is rich in protein and can supply essential elements for ruminants.
Mohamed Rashid, Hadeer M. Aboshady, Yosra A. Soltan, Harry Archimede, Wafaa M. A. Ghoneem   +4 more
doaj   +2 more sources

Effect of Lentinus sajor-caju on the chemical composition and antioxidant activity of highland barley straw under solid-state fermentation [PDF]

Frontiers in Microbiology
IntroductionThe efficient utilization of straw resources as animal feed has gained considerable attention. The objective of this study was to evaluate whether Lentinus sajor-caju treatment alters the chemical composition and antioxidant activity of ...
Yuqiong Wang, Yangci Liao, Changlong Gou, Hang Zhang, Liming Chen, Yuhong Bao   +5 more
doaj   +3 more sources

Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β–TFEB signaling axisAll raw data for the paper can be downloaded via the WeTransfer link.

Pharmacological Research
Lysosomal dysfunction is a core pathological driver of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Transcription factor EB (TFEB) serves as a master regulator of lysosomal biogenesis, and its pharmacological activation ...
Ang Li, Xianglu Xiao, Guopan Liu, Krinos Li, Yixia Ling, Shenglong Deng, Chunzuan Xu, Shu-Qin Cao, Jing Wen, Guang Lu, Guang Yang, Evandro F. Fang, Dajiang Qin, Huanxing Su   +13 more
doaj   +2 more sources

A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY. [PDF]

Theranostics
Rationale: Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery of new lipid-lowering medications is of paramount importance.
Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X, Ni X, Chen Y, Wang J, Liang X, Xie Z, Li J, Banach M, Pelisek J, Huo Y, Hu Y, Evans PC, Wang L, Tian XY, Xiao J, Shang Y, Zheng Y, Xian X, Weng J, Xu S.   +26 more
europepmc   +3 more sources

Isoginkgetin exerts apoptotic effects on A375 melanoma cells. [PDF]

MicroPubl Biol
Many plants produce secondary metabolites, known as flavonoids, which are thought to exhibit anti-cancer properties. Ginkgo biloba , a plant traditionally used in Chinese herbal medicine, is known to produce over 40 different secondary metabolites. Isoginkgetin, a biflavanoid from this species, has been demonstrated to be cytotoxic to different cancer ...
Mariano N, Wolf H, Vivekanand P.
europepmc   +3 more sources

Molecular docking analysis of furfural and isoginkgetin with heme oxygenase I and PPARγ [PDF]

Bioinformation, 2021
Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis.
Santhakumar, Preetha, Prathap, Lavanya, Roy, Anitha, Jayaraman, Selvaraj, Jeevitha, M   +4 more
openaire   +2 more sources