Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP [PDF]
, 2017 We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Abovich +51 more
core +5 more sources
Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation [PDF]
, 2019 T cells are nodal players in the adaptive immune response against pathogens and malignant cells. Alternative splicing plays a crucial role in T cell activation, which is analyzed mainly at later time points upon stimulation. Here we have discovered a 2-h
Bose, D. +4 more
core +2 more sources
Identification of small molecule inhibitors of pre-mRNA splicing [PDF]
, 2014 Background: There is a need for new small molecule pre-mRNA splicing inhibitors as biotools. Results: High throughput screening resulted in the identification of small molecule splicing inhibitors that are active in vitro and in cells.
Gray, David +8 more
core +2 more sources
A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing [PDF]
, 2019 The work was supported by the Biotechnology and Biological Sciences Research Council [Project grant BB/J007137/1] and a Medical Research Council (MRC) Confidence in Concept (2014) - University of Aberdeen Award (MC_PC_14114v.2). AA was supported by a PhD
Bachrach +53 more
core +3 more sources
Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro
Molecules, 2019 Ginkgo biloba L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid—amentoflavone 7′′-O-β-d-glucopyranoside (1)—and four known biflavonoids were isolated ...
Min Li +7 more
doaj +1 more source
Frontiers in Pharmacology, 2022 CYP3A4-mediated Phase I biotransformation is the rate-limiting step of elimination for many commonly used clinically agents. The modulatory effects of herbal medicines on CYP3A4 activity are one of the risk factors affecting the safe use of drug and ...
Bo Wang +18 more
doaj +1 more source
Effect of in vitro gastrointestinal digestion on the chemical composition and antioxidant properties of Ginkgo biloba leaves decoction and commercial capsules [PDF]
, 2022 In this study Ginkgo biloba leaves (GBL) decoction and commercial capsules were digested using an in vitro model. Thirty-six active compounds were identified and quantified by HPLC-ESI-MS analysis based on the MS/MS patterns (precursor ions and product ...
CAO, WEN +5 more
core +2 more sources
PLoS Genetics, 2021 The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could
Andrey A Parkhitko +8 more
doaj +1 more source
Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) [PDF]
, 2017 Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b ...
Bradshaw, Tracey D. +14 more
core +1 more source
Journal of Medicinal Chemistry, 2022 The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic and plasmatic stabilities, pharmacokinetic, off-target, etc.) as well as in vitro and in vivo ...
Letribot, Boris +9 more
openaire +3 more sources