Results 41 to 50 of about 683 (145)

The splicing inhibitor isoginkgetin induces transcription of metallothionein genes through the metal responsive transcription factor MTF-1

Pre-mRNA splicing is a critical step in the formation of mature mRNAs and when dysregulated, can contribute to the development/progression of many diseases.
Claire Peneycad
openalex   +3 more sources

The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing* [PDF]

Journal of Biological Chemistry, 2008
Melissa J. Moore
exaly   +2 more sources

Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2

Frontiers in Pharmacology, 2021
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song, Yun-Qing Song, Rong-Jing He, Dan Pu, Dan Pu, Xiao-Qing Guan, Jin-Hui Shi, Yao-Guang Li, Jie Hou, Shou-Ning Jia, Wei-Wei Qin, Wei-Wei Qin, Sheng-Quan Fang, Guang-Bo Ge, Guang-Bo Ge   +14 more
doaj   +1 more source

In silico analysis, modelling and docking studies on the etfB and etfC virulence proteins of the fish pathogen Edwardsiella tarda

Journal of Microbiology and Infectious Diseases, 2023
Background: In-silico analysis and molecular docking tools offer alternative ploy to characterize the virulence factors of Edwardsiella tarda and identify potential herbal antimicrobial compounds as substitutes to overcome the adverse health effects of ...
Balakrishnan Naveen Rajeshwar, Thangapalam Jawahar Abraham   +1 more
doaj   +1 more source

m6A‐Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia

Advanced Science, Volume 10, Issue 34, December 6, 2023., 2023
M6A‐modified circTET2 modulated by RBMX and YTHDC1 binds to HNRNPC and promotes its translocation from nucleus to cytoplasm. CP028 modulates the expression of circTET2 and promotes the apoptosis of CLL cells. The RNA‐protein complex in cytoplasm activates the mTORC1 signaling pathway and interacts with the 3′ end of CPT1A mRNA to regulate the FAO of ...
Zijuan Wu, Xiaoling Zuo, Wei Zhang, Yongle Li, Renfu Gui, Jiayan Leng, Haorui Shen, Bihui Pan, Lei Fan, Jianyong Li, Hui Jin   +10 more
wiley   +1 more source

The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

MedComm, Volume 3, Issue 3, September 2022., 2022
A comprehensive summary of recent advances in SARS‐CoV‐2 3CLpro inhibitors (including marketed drugs, peptidomimetic, and non‐peptidomimetic synthetic compounds, as well as natural compounds and their derivatives), including the inhibitory activities, inhibitory mechanisms, and key structural features, provides new insights for designing and developing
Qing Hu, Yuan Xiong, Guang‐Hao Zhu, Ya‐Ni Zhang, Yi‐Wen Zhang, Ping Huang, Guang‐Bo Ge   +6 more
wiley   +1 more source

Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with In Vivo Antitumor Activity

, 2022
The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic ...
Alain Pruvost (427186), Mouad Alami (1312875), Romain Darrigrand (12184824), Valerie Salgues (12184827), Dolor Renko (2850221), Boris Letribot (8836610), Megane Nascimento (12184818), Samir Messaoudi (1433218), Giulia Cerrato (12184821), Sebastien Apcher (361032)   +9 more
core   +1 more source

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity,
Noor-E-Tabassum, Rajib Das, Mashia Subha Lami, Arka Jyoti Chakraborty, Saikat Mitra, Trina Ekawati Tallei, Rinaldi Idroes, Amany Abdel-Rahman Mohamed, Md. Jamal Hossain, Kuldeep Dhama, Gomaa Mostafa-Hedeab, Talha Bin Emran, Harquin Simplice Foyet   +12 more
wiley   +1 more source

Isoginkgetin Inhibits Insulin-Like Growth Factor-1-Induced Sebum Production in Cultured Human Sebocytes [PDF]

, 2018
Yul-Lye Hwang, Min‐Ho Lee, Hyun-In Oh, Hyungjin Kim, Cho-Ah Lim, Jeung‐Hoon Lee, Chang Deok Kim   +6 more
openalex   +2 more sources

Global spliceosome activity regulates entry into cellular senescence

The FASEB Journal, Volume 35, Issue 1, January 2021., 2021
Abstract Cellular senescence is a state of permanent growth arrest that can ultimately contribute to aging. Senescence can be induced by various stressors and is associated with a myriad of cellular functions and phenotypic markers. Alternative splicing is emerging as a critical contributor to senescence and aging.
So Mee Kwon, Seongki Min, Un‐woo Jeoun, Min Seok Sim, Gu Hyun Jung, Sun Mi Hong, Byul A. Jee, Hyun Goo Woo, Changhan Lee, Gyesoon Yoon   +9 more
wiley   +1 more source