Results 61 to 70 of about 683 (145)

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

, 2006
Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified.
Yoon, Sang-Oh, S O Yoon, Shin, Sejeong, Chung, An-Sik, Ho Jae Lee, A S Chung, S Shin, Lee, Ho-Jae, Hyo Kon Chun, Chun, Hyo-Kon   +9 more
core   +1 more source

Additional file 3 of Revealing RCOR2 as a regulatory component of nuclear speckles

, 2021
Additional file 3: Figure S3. (A, B) HeLa cells were stained against RCOR2 (green) and SRRM2 (red) after treatments with high doses of actinomycin D (A) and isoginkgetin (D).
Carlos Rivera (721642), Duxan Arancibia (11754265), Anna Lappala (11754268), Fabián Guzmán (11754271), Daniel Verbel-Vergara (11754262), María Estela Andrés (11754277), Marcela González (760992), Jeannie T. Lee (7866947), Gianluca Merello (11754274)   +8 more
core   +1 more source

Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma

, 2022
Isoginkgetin (ISO), a natural biflavonoid, exhibited cytotoxic activity against several types of cancer cells. However, its effects on hepatocellular carcinoma (HCC) cells and mechanism remain unclear. Here, we revealed that ISO effectively inhibited HCC
Jie Yao (1440151), Jia Fei (90457), Guangyi Yang (1963231), Jun Tian (308922), Qinghua Chen (717989), Xudong Tang (12141), Yuyang Miao (9969110), Lanlan Ge (2074681), Baoru Ou (13570424), Dongyu Liu (5684906), Yunzhi Lin (525862), Shuming Tang (13570421), Chenyan Shi (748275), Qiujie Xie (13570427), Xiaobin Zeng (8458737)   +14 more
core   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Effect of sciadopitysin on sodium arsenite-induced senescence of rat hippocampal neurons

环境与职业医学, 2022
BackgroundIn addition to the typical signs of skin damage, long-term arsenic exposure is often accompanied by signs and symptoms of neurobehavioral abnormalities.ObjectiveTo investigate potential intervention effect of sciadopitysin on senescence of ...
Cheng CHEN, Xiong CHEN, Aihua ZHANG
doaj   +1 more source

In silico molecular docking and ADMET prediction of Ginkgo biloba biflavonoids as dual inhibitors of human HMG-CoA reductase and α-amylase [PDF]

Journal of the Serbian Chemical Society
There is an increasing interest in investigating phytochemicals as inhibitors of HMG-CoA reductase (HMGR) and α-amylase enzymes. Inhibition of these enzymes helps manage hypercholesterolemia and diabetes by reducing cholesterol synthesis and blood sugar ...
Agosto Nesteve John B.
doaj   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

The strong propensity of Cadherin‐23 for aggregation inhibits cell migration

Molecular Oncology, Volume 13, Issue 5, Page 1092-1109, May 2019., 2019
Cadherin‐23 (Cdh23, in dark red), a long‐chain non‐classical cadherin, exhibits strong homophilic and heterophilic binding. Cdh23 is uniformly expressed in different normal tissues (in blue) and mediates strong cell–cell adhesion junctions. It is down‐regulated in cancer cells (in red) by promoter methylation and produces soluble isoforms (in green ...
Malay K. Sannigrahi, Cheerneni S. Srinivas, Nilesh Deokate, Sabyasachi Rakshit   +3 more
wiley   +1 more source

Plant of the Millennium, Caper (Capparis spinosa L.), chemical composition and medicinal uses

Bulletin of the National Research Centre, 2021
Background Caper (Capparis spinosa L.) is a common member of the genus Capparis, which is a perennial shrub and thorny, and a common aromatic plant in many parts of the world, especially the Mediterranean regions.
Mohamad Hesam Shahrajabian, Wenli Sun, Qi Cheng   +2 more
doaj   +1 more source

TCMD: A High‐Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio‐Based Resources

Advanced Science, Volume 12, Issue 27, July 17, 2025.
This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu, Yueyao Wang, Yongming Chen, Yunxia Wang, Shicheng Zhang, Gang Luo, Fuhao Cui, Taisheng Du, Zhidan Liu   +8 more
wiley   +1 more source