Effect of sciadopitysin on sodium arsenite-induced senescence of rat hippocampal neurons
环境与职业医学, 2022 BackgroundIn addition to the typical signs of skin damage, long-term arsenic exposure is often accompanied by signs and symptoms of neurobehavioral abnormalities.ObjectiveTo investigate potential intervention effect of sciadopitysin on senescence of ...
Cheng CHEN, Xiong CHEN, Aihua ZHANG
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Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance [PDF]
Molecular and Cellular Biology, 2019 Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these catabolic processes. We report here that isoginkgetin, a naturally derived biflavonoid, sensitized cells undergoing nutrient starvation to apoptosis, induced ...
Jessica, Tsalikis +6 more
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RETRACTED ARTICLE: Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury. [PDF]
Bioengineered, 2022 Li Y +10 more
europepmc +3 more sources
Chemical Biology of Splicing Inhibitors [PDF]
, 2014 埼玉大学博士(理学)77 p.Splicing of primary transcripts (pre-mRNA) removes non-coding intronic sequences and joins exonic sequences to make a mature mRNA that can be transported from the nucleus into the cytoplasm and translated into protein.
KHALID, KHAN, カリド, カーン
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Metabolomic Profiles of the Creeping Wood Sorrel Oxalis corniculata in Radioactively Contaminated Fields in Fukushima: Dose-Dependent Changes in Key Metabolites [PDF]
, 2022 The biological impacts of the Fukushima nuclear accident, in 2011, on wildlife have been studied in many organisms, including the pale grass blue butterfly and its host plant, the creeping wood sorrel Oxalis corniculata. Here, we performed an LC–MS-based
Otaki, M. Joji +2 more
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Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
The strong propensity of Cadherin‐23 for aggregation inhibits cell migration
Molecular Oncology, Volume 13, Issue 5, Page 1092-1109, May 2019., 2019 Cadherin‐23 (Cdh23, in dark red), a long‐chain non‐classical cadherin, exhibits strong homophilic and heterophilic binding. Cdh23 is uniformly expressed in different normal tissues (in blue) and mediates strong cell–cell adhesion junctions. It is down‐regulated in cancer cells (in red) by promoter methylation and produces soluble isoforms (in green ...
Malay K. Sannigrahi +3 more
wiley +1 more source
Plant of the Millennium, Caper (Capparis spinosa L.), chemical composition and medicinal uses
Bulletin of the National Research Centre, 2021 Background Caper (Capparis spinosa L.) is a common member of the genus Capparis, which is a perennial shrub and thorny, and a common aromatic plant in many parts of the world, especially the Mediterranean regions.
Mohamad Hesam Shahrajabian +2 more
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Advanced Science, Volume 12, Issue 27, July 17, 2025.This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu +8 more
wiley +1 more source
BioMed Research International, Volume 2018, Issue 1, 2018., 2018 In the present study, the process of ultrasound‐assisted extraction (UAE) followed by macroporous resin purification was successfully developed to achieve maximal recovery of functional components (flavonoids and ginkgolides) with minimal contents of toxic components (alkylphenols) from Ginkgo biloba leaves.
Guisheng Zhou +8 more
wiley +1 more source