Results 71 to 80 of about 683 (145)

Bioengineered Nanozymes for Orthopedic Degenerative Diseases: From Catalytic Mechanisms to Multimodal Therapy

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
IDD and OA is caused by various mechanisms, creating a vicious cycle that impairs disc function. Nanozymes and nano‐enzyme delivery systems offer innovative therapies by targeting these underlying mechanisms, such as anti‐inflammatory therapy, ECM repair, cellular dysfunction and antioxidant therapy, providing a promising approach to restoring tissue ...
Lei Peng, Chen Yan, Honghao Song, Jiangang Shi, Kaiqiang Sun   +4 more
wiley   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome

Advanced Science, Volume 12, Issue 4, January 27, 2025.
A novel computational method called SMNPLS (Sparse Multi‐Network Regularized Partial Least Squares) is developed to extract modularized patterns from joint matrices of splicing factors expression and PSI (percent spliced‐in) values of alternative splicing events and uncovered the global landscape of splicing dysregulations by altered splicing factors ...
Jingru Sui, Dan Guo, Xiao Wen, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu   +7 more
wiley   +1 more source

The rate of lariat formation is decreased two-fold by isoginkgetin treatment.

, 2014
(A) Genome-wide expression of 5′ splice sites, 3′ splice sites, and introns are increased relative to exons upon treatment of HeLa cells with isoginkgetin (30 µM, 18 hours), based on total RNA-Seq (dUTP method [18], Illumina).
Thomas E. Mullen (16423), Nimrod Miller (304762), Steven A. McCarroll (229097), Jesse M. Gray (527662), Sarah A. Boswell (527664), Scott Kuersten (253274), Yong-Chao Ma (174419), Nicole Cloonan (263462), Sean M. Grimmond (132666), Michael Springer (37212), David A. Harmin (527663), Joseph J. Ling (527665)   +11 more
core   +1 more source

Plant‐Based Anticancer Compounds With a Focus on Breast Cancer

Cancer Reports, Volume 7, Issue 10, October 2024.
ABSTRACT Breast cancer is a common form of cancer among women characterized by the growth of malignant cells in the breast tissue. The most common treatments for this condition include chemotherapy, surgical intervention, radiation therapy, hormone therapy, and biological therapy.
Amin Moradi Hasan‐Abad, Amir Atapour, Ali Sobhani‐Nasab, Hossein Motedayyen, Reza ArefNezhad   +4 more
wiley   +1 more source

Safety and efficacy of feed additives consisting of ginkgo tinctures obtained from the leaves of Ginkgo biloba L. for use in all animal species (FEFANA asbl)

EFSA Journal, Volume 22, Issue 5, May 2024.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of tinctures obtained from the dried leaves of Ginkgo biloba L. (ginkgo tinctures) when used as sensory additives.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Yvette Dirven, Paola Manini, Birgit Dusemund   +22 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of a dry extract obtained from the leaves of Ginkgo biloba L. (ginkgo extract) for horses, dogs, cats, rabbits and guinea pigs (FEFANA asbl)

EFSA Journal, Volume 22, Issue 4, April 2024.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a feed additive obtained from the dried leaves of Ginkgo biloba L. (ginkgo extract) when used as a sensory additive in feed for horses, dogs, cats, rabbits and guinea pigs.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Yvette Dirven, Paola Manini, Birgit Dusemund   +22 more
wiley   +1 more source

In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis

Scientific Reports, 2020
Plants are endowed with a large pool of structurally diverse small molecules known as secondary metabolites. The present study aims to virtually screen these plant secondary metabolites (PSM) for their possible anti-SARS-CoV-2 properties targeting four ...
Hariprasad Puttaswamy, Hittanahallikoppal Gajendramurthy Gowtham, Monu Dinesh Ojha, Ajay Yadav, Gourav Choudhir, Vasantharaja Raguraman, Bhani Kongkham, Koushalya Selvaraju, Shazia Shareef, Priyanka Gehlot, Faiz Ahamed, Leena Chauhan   +11 more
doaj   +1 more source

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Food Frontiers, Volume 5, Issue 2, Page 267-310, March 2024.
Abstract The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” ones, opening avenues for the development of novel hallmark‐targeted pro‐longevity approaches.
Monika N. Todorova, Martina S. Savova, Liliya V. Mihaylova, Milen I. Georgiev   +3 more
wiley   +1 more source

MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2

, 2021
The global spread of SARS-CoV-2 has resulted in millions of fatalities worldwide, making it crucial to identify potent antiviral therapeutics to combat this virus.
Monica Sharma (1764358), Preeti Dhaka (11347522), Pravindra Kumar (106427), Neetu Neetu (11347525), Shailly Tomar (289164), Jai Krishna Mahto (11347519)   +5 more
core   +1 more source