Results 71 to 80 of about 801 (163)
In silico molecular docking and ADMET prediction of Ginkgo biloba biflavonoids as dual inhibitors of human HMG-CoA reductase and α-amylase [PDF]
Journal of the Serbian Chemical SocietyThere is an increasing interest in investigating phytochemicals as inhibitors of HMG-CoA reductase (HMGR) and α-amylase enzymes. Inhibition of these enzymes helps manage hypercholesterolemia and diabetes by reducing cholesterol synthesis and blood sugar ...
Agosto Nesteve John B.
doaj +1 more source
Characterization of Antisense RNAs Derived From RNA Polymerase II’s RdRP Activity [PDF]
, 2021 Conventionally, RNA Polymerase II (Pol II) transcribes RNA using a DNA template in a DNA-dependent RNA polymerization (DdRP) reaction. However, Pol II also has RNAdependent RNA polymerase (RdRP) activity, the biological significance of which remains ...
Jourabchi, Tara
core +1 more source
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.IDD and OA is caused by various mechanisms, creating a vicious cycle that impairs disc function. Nanozymes and nano‐enzyme delivery systems offer innovative therapies by targeting these underlying mechanisms, such as anti‐inflammatory therapy, ECM repair, cellular dysfunction and antioxidant therapy, providing a promising approach to restoring tissue ...
Lei Peng +4 more
wiley +1 more source
Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment
BioMed Research International, Volume 2016, Issue 1, 2016., 2016 In eukaryotes, genes are frequently interrupted with noncoding sequences named introns. Alternative splicing is a nuclear mechanism by which these introns are removed and flanking coding regions named exons are joined together to generate a message that will be translated in the cytoplasm. This mechanism is catalyzed by a complex machinery known as the
Nancy Martínez-Montiel +5 more
wiley +1 more source
SELAGINELLA ACTIVE FRACTIONS INDUCE APOPTOSIS ON T47D BREAST CANCER CELL [PDF]
, 2012 Apoptosis is an important target on anticancer mechanism. The purpose of this research is to investigate apoptosis induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol was used to extract Selaginella
Andriyani, Rina +5 more
core +2 more sources
Natural products targeting tumour angiogenesis
British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source
Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015 Due to the high incidence and severity of obesity and its related disorders, it is highly desirable to develop new strategies to treat or even to prevent its development. We have previously described that Ginkgo biloba extract (GbE) improved insulin resistance and reduced body weight gain of obese rats.
Bruna Kelly Sousa Hirata +9 more
wiley +1 more source
A review on the medical effects of Capparis spinosa L. [PDF]
, 2016 Background and aims: Plants are a valuable source of wide range of secondary metabolites. Caper (Capparis spinosa L.) belongs to the Capparaceae family. It has a lot of medical uses especially in medical fields.
Rahnavard, R., Razavi, N.
core
Characterization of the bone marrow niche in Acute Myeloid Leukemia patients [PDF]
, 2022 The bone marrow (BM) microenvironment (the niche) plays a critical role in regulating normal hematopoietic process and is dysregulated in bone and marrow-related malignancies such as Acute Myeloid Leukemia (AML).
Henly, Charisa
core
Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome
Advanced Science, Volume 12, Issue 4, January 27, 2025.A novel computational method called SMNPLS (Sparse Multi‐Network Regularized Partial Least Squares) is developed to extract modularized patterns from joint matrices of splicing factors expression and PSI (percent spliced‐in) values of alternative splicing events and uncovered the global landscape of splicing dysregulations by altered splicing factors ...
Jingru Sui +7 more
wiley +1 more source