Results 91 to 100 of about 801 (163)

Decreased YB‐1 expression denervates brown adipose tissue and contributes to age‐related metabolic dysfunction

Cell Proliferation, Volume 57, Issue 1, January 2024.
In this study, we found that dysregulated butyrate levels in aging mice decreased YB‐1 expression in the brown adipose tissue (BAT), which aggravates aging‐related BAT dysfunction. Mechanistically, YB‐1 promotes BAT function by facilitating sympathetic innervation via producing Slit2.
Ruoyu Zhou, Yan Huang, Xu Feng, Rui Zhou, Liwen Wang, Genqing Xie, Yuan Xiao, Haiyan Zhou   +7 more
wiley   +1 more source

Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves [PDF]

, 2014
BACKGROUND: Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was
Bagla, Victor Patrick, Elgorashi, Esam E., Eloff, Jacobus Nicolaas, McGaw, Lyndy Joy   +3 more
core   +1 more source

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy [PDF]

, 2013
Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments.
Claudia Ghigna, Daniela Pignataro, Giuseppe Biamonti, Morena Catillo, Serena Bonomi, Stefania Gallo   +5 more
core   +2 more sources

From Waste to Resource: Valorization of Yellow Ginkgo Leaves as a Source of Pharmacologically Relevant Biflavonoids

Applied Sciences
Ginko (Ginkgo biloba L.) is a widely distributed ornamental tree that produces large quantities of leaves annually, turning golden yellow in autumn due to chlorophyll degradation and carotenoid retention.
Iva Jurčević Šangut, Dunja Šamec
doaj   +1 more source

Splice Modulation Synergizes Cell Cycle Inhibition. [PDF]

, 2020
While recognized as a therapeutic target, the spliceosome may offer a robust vector to improve established therapeutics against other protein targets.
Burkart, Michael, La Clair, James, Trieger, Kelsey   +2 more
core   +1 more source

Pre-mRNA splicing repression triggers abiotic stress signaling in plants [PDF]

, 2017
[EN] Alternative splicing (AS) of precursor RNAs enhances transcriptome plasticity and proteome diversity in response to diverse growth and stress cues.
Alshareef, Sahar, Arold, Stefan, Butt, Haroon, Duque, Paula, Fujii, Hiroaki, Galal, Aya A., Li, Lixin, Ling, Yu, Lozano Juste, Jorge, Mahfouz, Magdy M., Momin, Afaque A., Moustafa, Ahmed, Richardson, Dale N., Rodríguez Egea, Pedro Luís, Tashkandi, Manal   +14 more
core   +1 more source

Effets de plantes réputées antidiabétiques sur un modèle cellulaire hépatique de résistance à l’insuline induite par le palmitate [PDF]

, 2010
La pharmacopée Cris est riche en plantes médicinales et plusieurs d’entre elles sont étudiées par notre laboratoire pour leur potentiel antidiabétique.
Afshar, Arvind
core  

Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage.

, 2012
The removal of intervening sequences (introns) from a primary RNA transcript is catalyzed by the spliceosome, a large ribonucleoprotein complex. At the start of each splicing cycle, the spliceosome assembles anew in a sequentially ordered manner on the ...
Canzoneri, J., Lührmann, R., Oyelere, A., Patil, V., Samatov, T.   +4 more
core   +1 more source

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. [PDF]

, 2017
Small molecule inhibitors of pre-mRNA splicing are important tools for identifying new spliceosome assembly intermediates, allowing a finer dissection of spliceosome dynamics and function. Here, we identified a small molecule that inhibits human pre-mRNA
Agafonov, D., Anokhina, M., Bao, P., Ceballos, J., Kastner, B., Lührmann, R., Samatov, T., Sidarovich, A., Sievers, S., Urlaub, H., Waldmann, H., Will, C.   +11 more
core   +1 more source

Secondary Metabolites from Bolivian Plants- Isolation and Characterization [PDF]

, 2014
Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess ...
Davila, Marcelo
core