Results 51 to 60 of about 683 (145)

Comprehensive Evaluation of Fructus Tsaoko, Seeds of Tsaoko Fructus and Ginger Made Seeds of Tsaoko Fructus Based on Drug-Like Compounds and Aroma Analysis. [PDF]

Food Sci Nutr
This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Chen H, Yang M, Yang W, Qi M, Xu Z, Yang T, Zhang J.   +6 more
europepmc   +2 more sources

A Phytochemical and Biological Investigation of Some Plants Belong to Cycadales Order Cultivated in Egypt: Thesis Abstract [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2021
Background: Gymnosperms are naked seed-producing plants and still a dark area in scientific researches although they considered as a rare gift of the nature. Cycads are one of the largest groups of living Gymnosperms.
Walaa Negm, Kamilia Abo El-Seoud, Amal Kabbash, Mona El-Aasr   +3 more
doaj   +1 more source

Preparation, evaluation and metabolites study in rats of novel Isoginkgetin-loaded TPGS/soluplus mixed nanomicelles

, 2020
Xue Feng, Yuting Chen, Lu-Ya Li, Yupeng Sun, Hairong Wang, Lantong Zhang   +5 more
openalex   +3 more sources

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1

Frontiers in Pharmacology, 2022
Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang, Guang-Hao Zhu, Qi-Hang Zhou, Chun-Zhi Ai, Ya-Di Zhu, Ping Wang, Tong-Yi Dou, Yang-Liu Xia, Hong Ma, Guang-Bo Ge   +9 more
doaj   +1 more source

Flavonoids and Phenolic Compounds From the Parasitic Gymnosperm Endemic to New Caledonia

Natural Product Communications, 2022
Parasitaxus usta (Podocarpaceae) is the only parasitic gymnosperm and endemic to New Caledonia. In this survey, 11 flavonoids and 6 phenolic compounds were isolated from the aerial parts.
Tsukasa Iwashina, Hiroshi Tobe, Takahisa Nakane, Takayuki Mizuno, Tanguy Jaffré   +4 more
doaj   +1 more source

Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina

Frontiers in Pharmacology, 2022
CYP3A4-mediated Phase I biotransformation is the rate-limiting step of elimination for many commonly used clinically agents. The modulatory effects of herbal medicines on CYP3A4 activity are one of the risk factors affecting the safe use of drug and ...
Bo Wang, Bo Wang, Chao Shi, Lei Feng, Lei Feng, Lei Feng, Wei Pan, Xiang-Ge Tian, Cheng-Peng Sun, Chao Wang, Jing Ning, Xia Lv, Yan Wang, Qian-Hui Yuan, Rui-Xuan Guan, Hou-Li Zhang, Xiao-Chi Ma, Xiao-Chi Ma, Tong-Hui Ma   +18 more
doaj   +1 more source

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.

PLoS Genetics, 2021
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could
Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J Lord, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon   +8 more
doaj   +1 more source

Polyphenolic promiscuity, inflammation-coupled selectivity: Whether PAINs filters mask an antiviral asset

Frontiers in Pharmacology, 2022
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection.
Rick Sheridan, Kevin Spelman, Kevin Spelman   +2 more
doaj   +1 more source

The spliceosome inhibitor isoginkgetin activates an ATF4-dependent transcriptional response

, 2023
Gene expression is a highly regulated process that is essential to produce diverse proteins and RNAs required for life. The transfer of genetic information from gene to protein involves many steps including transcription of DNA to pre-mRNA, pre-mRNA ...
van Zyl, Erin Patricia
core   +1 more source

Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Background. Although the combination of Zingiberis rhizoma (ZR) and Coptidis rhizoma (CR) is a classic traditional Chinese medicine‐based herbal pair used for its antitumor effect, the material basis and underlying mechanisms are unclear. Here, a network pharmacology approach was used to elucidate the antitumor mechanisms of ZR‐CR.
Meng Wang, Youke Qi, Yongning Sun, Rui Liu   +3 more
wiley   +1 more source