Results 31 to 40 of about 801 (163)
Isoginkgetin Induces Caspase Cascade Activation and Cell Apoptosis via JNK Signaling in Oral Cancer. [PDF]
J CancerIsoginkgetin (IGG), a naturally occurring biflavonoid found in the leaves of many medicinal plants, is known to inhibit pre-mRNA splicing and display anti-cancer characteristics. However, knowledge regarding the use of IGG on oral squamous cell carcinoma (OSCC) lags behind that on the other common malignancies.
Yang WE +8 more
europepmc +4 more sources
Frontiers in Pharmacology, 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song +14 more
doaj +1 more source
Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1 [PDF]
, 2023 Novel biomarkers and therapeutic strategies for prostate-cancer (PCa) are required to overcome its lethal progression. The dysregulation/implication of the RNA-Exosome-complex (REC; cellular machinery controlling the 3′-5′processing/degradation of most ...
Gahete Ortiz, Manuel D. +10 more
core +1 more source
Journal of Microbiology and Infectious Diseases, 2023 Background: In-silico analysis and molecular docking tools offer alternative ploy to characterize the virulence factors of Edwardsiella tarda and identify potential herbal antimicrobial compounds as substitutes to overcome the adverse health effects of ...
Balakrishnan Naveen Rajeshwar +1 more
doaj +1 more source
Advanced Science, Volume 10, Issue 34, December 6, 2023., 2023 M6A‐modified circTET2 modulated by RBMX and YTHDC1 binds to HNRNPC and promotes its translocation from nucleus to cytoplasm. CP028 modulates the expression of circTET2 and promotes the apoptosis of CLL cells. The RNA‐protein complex in cytoplasm activates the mTORC1 signaling pathway and interacts with the 3′ end of CPT1A mRNA to regulate the FAO of ...
Zijuan Wu +10 more
wiley +1 more source
The spliceosome inhibitor isoginkgetin activates an ATF4-dependent transcriptional response [PDF]
, 2023 Gene expression is a highly regulated process that is essential to produce diverse proteins and RNAs required for life. The transfer of genetic information from gene to protein involves many steps including transcription of DNA to pre-mRNA, pre-mRNA ...
van Zyl, Erin Patricia
core +2 more sources
The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
MedComm, Volume 3, Issue 3, September 2022., 2022 A comprehensive summary of recent advances in SARS‐CoV‐2 3CLpro inhibitors (including marketed drugs, peptidomimetic, and non‐peptidomimetic synthetic compounds, as well as natural compounds and their derivatives), including the inhibitory activities, inhibitory mechanisms, and key structural features, provides new insights for designing and developing
Qing Hu +6 more
wiley +1 more source
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 [PDF]
, 2022 COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2 ...
Afladhanti, Putri Mahirah Afladhanti +4 more
core +3 more sources
Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity,
Noor-E-Tabassum +12 more
wiley +1 more source
Global spliceosome activity regulates entry into cellular senescence
The FASEB Journal, Volume 35, Issue 1, January 2021., 2021 Abstract Cellular senescence is a state of permanent growth arrest that can ultimately contribute to aging. Senescence can be induced by various stressors and is associated with a myriad of cellular functions and phenotypic markers. Alternative splicing is emerging as a critical contributor to senescence and aging.
So Mee Kwon +9 more
wiley +1 more source