A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY [PDF]
TheranosticsRationale: Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery of new lipid-lowering
Yitong Xu, Zhidan Zhang, Zhenghong Liu
exaly +6 more sources
Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens [PDF]
Communications Biology, 2021 Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen ...
Romain Darrigrand +11 more
doaj +3 more sources
A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
doaj +3 more sources
Virtual Screening of Soybean Protein Isolate-Binding Phytochemicals and Interaction Characterization [PDF]
Foods, 2023 Soybean protein isolate (SPI) and small molecule interactions have drawn more and more attention regarding their benefits for both parts, while research on large-scale investigations and comparisons of different compounds is absent. In this study, a high
Panhang Liu +3 more
doaj +3 more sources
The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death.
PLoS ONE, 2020 The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins.
Erin J Vanzyl +5 more
doaj +4 more sources
Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas +2 more
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Network Pharmacology-Based Identification of Potential Targets and Mechanisms of Isoginkgetin in Gastric Cancer. [PDF]
Biomed Res IntBackground Isoginkgetin (ISO) is a natural flavonoid with potential anticancer effects. However, the anticancer mechanisms of ISO in gastric cancer remain insufficiently explored. Methods Network pharmacology, TCGA data analysis, and molecular docking were employed to identify potential ISO targets and their involvement in gastric cancer ...
Li L, Zhu H, Cao K, Chen H.
europepmc +3 more sources
Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. [PDF]
PLoS ONE, 2018 The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E,
Erin J Vanzyl +4 more
doaj +3 more sources
Journal of Medicinal Chemistry, 2022 The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic ...
Sébastien Apcher +2 more
exaly +4 more sources
Microarray dataset supporting a role for ATF4 in isoginkgetin-induced gene expression in HCT116 cells. [PDF]
Data in Brief, 2022 Isoginkgetin (IGG) is a compound originally derived from the leaves of Ginkgo biloba trees. It was subsequently identified through a chemical screen to be an inhibitor of both the major and minor spliceosome, with an IC50 value of 30 µM [1].
Erin van Zyl +2 more
doaj +2 more sources