3′,8″-Dimerization Enhances the Antioxidant Capacity of Flavonoids: Evidence from Acacetin and Isoginkgetin [PDF]
Molecules, 2019 To probe the effect of 3′,8″-dimerization on antioxidant flavonoids, acacetin and its 3′,8″-dimer isoginkgetin were comparatively analyzed using three antioxidant assays, namely, the ·O2− scavenging assay, the Cu2 ...
Xican Li, Dongfeng Chen
exaly +5 more sources
Isoginkgetin protects chondrocytes and inhibits osteoarthritis through NF-κB and P21 signaling pathway [PDF]
Molecular MedicineObjective Osteoarthritis (OA) is the most prevalent chronic articular disease in adults. The degree of cartilage degradation and matrix depletion in OA have been substantially connected with chondrocyte inflammatory response.
Mengdai Xu +4 more
doaj +4 more sources
Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling [PDF]
Redox Biology, 2022 Obesity-induced metabolic cardiomyopathy (MC), characterized by lipotoxicity and excessive oxidative stress, emerges as the leading cause of heart failure in the obese patients. Yet, its therapy remains very limited.
Xiaoqian Wu +9 more
doaj +4 more sources
Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells [PDF]
Journal of Nanobiotechnology, 2023 Excessive reactive oxygen species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and cellular inflammatory responses by activating a variety of cellular pathways, ultimately inducing cell apoptosis and leading to ...
Hao Yu +11 more
doaj +4 more sources
Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. [PDF]
PLoS ONE, 2018 The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E,
Erin J Vanzyl +4 more
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Correction: Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. [PDF]
PLoS ONE[This corrects the article DOI: 10.1371/journal.pone.0191178.].
Erin van Zyl +4 more
doaj +3 more sources
Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens [PDF]
Communications Biology, 2021 Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen ...
Romain Darrigrand +11 more
doaj +3 more sources
Isoginkgetin and Madrasin are poor splicing inhibitors [PDF]
, 2023 The production of eukaryotic mRNA requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation (CPA). Pol II can positively affect co-transcriptional processing through
Tellier M, Ansa G, Murphy S.
europepmc +3 more sources
The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death.
PLoS ONE, 2020 The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins.
Erin J Vanzyl +5 more
doaj +5 more sources
Data in Brief, 2022 Isoginkgetin (IGG) is a compound originally derived from the leaves of Ginkgo biloba trees. It was subsequently identified through a chemical screen to be an inhibitor of both the major and minor spliceosome, with an IC50 value of 30 µM [1].
Erin van Zyl +2 more
doaj +3 more sources