The Mechanistic Perspective of Bilobetin Protective Effects against Cisplatin-Induced Testicular Toxicity: Role of Nrf-2/Keap-1 Signaling, Inflammation, and Apoptosis [PDF]
Biomedicines, 2022 Cisplatin (CP) is a productive anti-tumor used to treat numerous tumors. However, multiple toxicities discourage prolonged use, especially toxicity on the reproductive system.
Aya H EL-Kadem +2 more
exaly +4 more sources
In silico identification of bilobetin and ginsenoside as dual CK2 and ULK2 inhibitors targeting triple-negative breast cancer [PDF]
Scientific ReportsTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of hormone receptors and HER2 amplification, which limits the effectiveness of standard targeted therapies.
Mukul Jain +2 more
exaly +3 more sources
Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids. Their precise distribution among plants and their role in plants is still unknown.
Marija Kovač Tomas +2 more
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A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8″-Biflavones and Their Monomeric Subunits [PDF]
Antioxidants, 2023 Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an effective new scaffold for drug discovery. In particular, 3′-8″-biflavones exhibit antiviral and antimicrobial activity and are promising molecules for the treatment ...
Iva Jurčević Šangut +3 more
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Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.) [PDF]
Plants, 2022 Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine.
Dunja Šamec +3 more
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In silico characterization of bioactive phytochemicals as antivirals targeting the reovirus σ1 protein for inhibiting σ1-mediated host cell entry. [PDF]
PLoS ONEMammalian orthoreoviruses (MRVs), commonly known as reoviruses, are an emerging zoonotic threat that are known for their broad host tropism and potential for causing severe clinical pathology in both humans and animals.
Eitu Dey +6 more
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Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 [PDF]
Frontiers in Pharmacology, 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song +14 more
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Frontiers in Bioscience, 2023 Background: Hepatocellular carcinoma (HCC/LIHC) is the most common type of primary liver cancer, which is a leading cause of cancer death worldwide. Patients with HCC have a short survival time after diagnosis.
Ming Yang, Chunye Zhang, Shuai Liu
exaly +3 more sources
Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1 [PDF]
Frontiers in Pharmacology, 2022 Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang +9 more
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High-performance liquid chromatography – diode array detection method validation for amentoflavone-type biflavonoids in five Encephalartos species with potential neuroprotective activity [PDF]
Scientific ReportsGinkgo biloba is a well-known food supplement for enhancing memory and is rich in biflavonoids. Biflavonoids are predominant in the Order Cycadales (cycads). Among cycads, five Encephalartos species, E. ferox, E. kisambo, E. laurentianus, E.
Zainab G. El-Natory +4 more
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