Results 31 to 40 of about 751 (112)

Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis [PDF]

Chinese Medical Journal
Aqu Alu, Zedong Jiang, Xuejiao Han, Yuan Cheng, Furong Qin, Yanghong Ni, Hao Zeng, Qingfang Li, Yanlin Song, Xuelei Ma, Yuanyuan Ji   +10 more
doaj   +2 more sources

Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2

Frontiers in Pharmacology, 2021
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song, Yun-Qing Song, Rong-Jing He, Dan Pu, Dan Pu, Xiao-Qing Guan, Jin-Hui Shi, Yao-Guang Li, Jie Hou, Shou-Ning Jia, Wei-Wei Qin, Wei-Wei Qin, Sheng-Quan Fang, Guang-Bo Ge, Guang-Bo Ge   +14 more
doaj   +1 more source

Quantitative Analysis of Flavonols and Their Glycosides and Gastrointestinal Transformation of Flavonol Glycosides in Yinxing Mihuan Oral Solution. [PDF]

J Anal Methods Chem
Yinxing Mihuan Oral Solution (YMOS) is extensively utilized in the clinical treatment of cardiovascular and cerebrovascular diseases (CCVDs), with flavonols and their glycosides identified as the primary active ingredients. Currently, there are relatively few established quantitative methods available for analyzing flavonols and their glycosides, and ...
Lyu Y, Cheng W, Niu K, He S, Ma L, Yang J, Yu H.   +6 more
europepmc   +2 more sources

Coupling Ultrasound with Heat-Reflux to Improve the Extraction of Quercetin, Kaempferol, Ginkgetin and Sciadopitysin from Mairei Yew Leaves

Applied Sciences, 2019
The coupling of ultrasound and heat⁻reflux extraction (UHRE) was developed for separation for quercetin (QU), kaempferol (KA), ginkgetin (GI) and sciadopitysin (SC) from Mairei Yew leaves.
Chunjian Zhao, Xueting Ren, Chunying Li, Hongwei Jiang, Jiajing Guan, Weiran Su, Yuzheng Li, Yao Tian, Tingting Wang, Shen Li   +9 more
doaj   +1 more source

Exogenous γ-aminobutyric acid strengthens phenylpropanoid and nitrogen metabolism to enhance the contents of flavonoids, amino acids, and the derivatives in edamame

Food Chemistry: X, 2022
γ-aminobutyric acid (GABA) has been reported to improve stress resistance in plants. Nonetheless, little is known about the effects of GABA on the nutritional quality and regulatory mechanisms of edamame.
Gaobo Yu, Fengqiong Chen, Yating Wang, Qiusen Chen, Hanlin Liu, Jin Tian, Mengxue Wang, Chunyuan Ren, Qiang Zhao, Fengjun Yang, Yunyan Sheng, Jinpeng Wei, Yuxian Zhang   +12 more
doaj   +1 more source

Discovery of senolytics using machine learning

Nature Communications, 2023
Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer-Barreto, Andrea Quintanilla, Richard J. R. Elliott, John C. Dawson, Jiugeng Sun, Víctor M. Campa, Álvaro Lorente-Macías, Asier Unciti-Broceta, Neil O. Carragher, Juan Carlos Acosta, Diego A. Oyarzún   +10 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Optimization of Process Parameters of Extraction of Amentoflavone, Quercetin and Ginkgetin from Taxus chinensis Using Supercritical CO2 Plus Co-Solvent

Molecules, 2014
The effects of extraction time, temperature, pressure and different concentration of ethanol and their interactions on the yields of amentoflavone, quercetin and ginkgetin extracted from Taxus chinensis by supercritical CO2 were investigated by using a ...
Xiao Ruan, Liu-Ye Yan, Xian-Xian Li, Ben Liu, Huan Zhang, Qiang Wang   +5 more
doaj   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

A Phenylpropanoid and Biflavonoids from the Needles of var.

Natural Product Communications, 2017
A phenylpropanoid [2-(3-methoxy-4-hydroxyphenyl)-propane-1,3-diol] (1) together with four known biflavonoids namely 7, 4′, 7′″, 4′″-tetra- O -methyl amentoflavone (2); 7, 4′, 7″-tri- O -methyl amentoflavone (3); ginkgetin (4); sequoiaflavone (5) were ...
Anju Mendiratta (Nee Chugh), Rameshwar Dayal, John P. Bartley, Graham Smith   +3 more
doaj   +1 more source