Results 31 to 40 of about 1,142 (187)
Scientific Reports, 2021 Atherosclerosis, a chronic inflammatory disease of large arteries, is the major contributor to the growing burden of cardiovascular disease-related mortality and morbidity.
Mazen O. Alharbi +5 more
doaj +1 more source
Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)
Plants, 2022 Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine.
Dunja Šamec +3 more
doaj +1 more source
Antibiotics, 2022 Enterococcus species possess many virulence factors that have an essential role in exacerbating the infections caused by them. The current study aimed to evaluate the effect of the secondary metabolites ginkgetin (GINK) and sotetsuflavone (SOTE ...
Nashwah G. M. Attallah +7 more
doaj +1 more source
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 [PDF]
, 2022 COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2 ...
Afladhanti, Putri Mahirah Afladhanti +4 more
core +3 more sources
Natural products targeting ferroptosis in cancer: molecular mechanisms and applications. [PDF]
Front OncolFerroptosis is a novel class of programmed cell death that is mainly dependent on intracellular iron accumulation and lipid peroxidation. Ferroptosis is closely related to a variety of human diseases, especially different kinds of cancer.
Ye X, Ju X.
europepmc +3 more sources
Ginkgetin ameliorates experimental atherosclerosis in rats
Biomedicine & Pharmacotherapy, 2018 Atherosclerosis is a common disease seriously detrimental to human health. Natural products are important sources of therapeutic candidates for atherosclerosis. We here evaluated the effects of ginkgetin on experimental atherosclerosis in rats and explored the underlying mechanisms.
Naqi, Lian +4 more
openaire +2 more sources
Functional stratification of cancer drugs through integrated network similarity [PDF]
, 2022 Drugs not only perturb their immediate protein targets but also modulate multiple signaling pathways. In this study, we explored networks modulated by several drugs across multiple cancer cell lines by integrating their targets with transcriptomic and ...
Beyge, Seyma Unsal, Tunçbağ, Nurcan
core +1 more source
Frontiers in Pharmacology, 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan.
Yun-Qing Song +14 more
doaj +1 more source
Synthetic flavonoids as novel modulators of platelet function and thrombosis [PDF]
, 2019 Cardiovascular diseases represent a major cause of mortality and morbidity in the world and thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within
Dina A. I. Albadawi +7 more
core +1 more source
Biomedicine & Pharmacotherapy, 2023 Doxorubicin (DOX) is a widely used chemotherapeutic agent for various tumors treatment; apart from its chemotherapeutic activity, the traditional usage of DOX has been limited by its adverse effects on multiple organs, mainly hepatotoxicity. The molecular mechanisms underlying DOX hepatotoxicity are mainly due to the production of reactive oxygen ...
Fatemah A, Alherz +4 more
openaire +2 more sources