Results 51 to 60 of about 751 (112)

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

BioMed Research International, Volume 2026, Issue 1, 2026.
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Aniket Singh, Sanjeev Kumar Sahu, Anil Kumar Sah, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source

Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1

Folia Neuropathologica, 2019
The present investigation evaluates the protective effect of Ginkgetin aglycone (GA) against ischemic stroke-induced neuronal injury. Ischemic stroke was produced by the middle cerebral artery occlusion (MCAO) model and animals were a group that received
Bing Xu, Xin He, Yi Sui, Xu Wang, Xia Wang, Li Ren, Yun-Xin Zhai   +6 more
doaj   +1 more source

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

Ampelopsis grossedentata (Vine Tea) Ethanol Extract Protects Against Oxidative Damage and Aging in Mice Via Nrf2 Activation

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Ampelopsis grossedentata, a traditional food–medicinal vine rich in flavonoids, was investigated here for its antiaging potential and underlying mechanisms. An ethanol extract (AGE) was chemically profiled by UHPLC–ESI–HRMS/MS (16 compounds identified; dihydromyricetin ≈192.7 mg g−1) and shown to contain high levels of phenolics and flavonoids (TPC 348.
Wei Weng, Yingfei Yang, Liangyu Shi, Kailing Pan, Haiyan Wang   +4 more
wiley   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Ferroptosis, a controlled cell death influenced by iron‐dependent lipid peroxidation, presents potential therapeutic targets for cancer treatment due to its unique molecular pathways and potential drug resistance. Natural compounds, such as polyphenols, flavonoids, terpenoids and alkaloids, can influence ferroptosis via important signalling ...
Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam, Patibandla Jahnavi, Jeetendra Kumar Gupta, Varikalla Rajashakar, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, G. Dharmamoorthy, Uppuluri Varuna Naga Venkata Arjun, Voleti Vijaya Kumar, Muath Suliman, Talha Bin Emran   +12 more
wiley   +1 more source

Millet Bran Bound Phenolic Compounds Suppresses LPS‐Induced Inflammatory Response in Macrophages and Liver Injury Mice via TLR4/NF‐κB Signaling Pathway

eFood, Volume 6, Issue 4, August 2025.
BPS‐2 alleviates liver injury mice and RAW264.7 cell inflammation via TLR4/NF‐κB pathway. ABSTRACT Millet bran, rich in bioactive phenolic compounds, holds potential for both nutritional and therapeutic applications. In this study, bound phenolic compounds were isolated from millet bran, yielding a potent fraction named BPS‐2.
Ying‐kun Cai, Jin‐yue Sun, Ying‐ying Chen, Meng‐qi Zhang, Shu‐tao Sun, Qi‐dong Ren, Mu‐xuan Wang, Mohamed A. Farag, Bo Zhang, Xu Guo, Chao Liu   +10 more
wiley   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Rapid Screening and Structural Characterization of Antioxidants from the Extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS Method

International Journal of Analytical Chemistry, 2015
2,2-Diphenyl-1-picrylhydrazyl-ultra-high performance liquid chromatography-Q-time-of-flight mass spectrometry (DPPH-UPLC-Q-TOF/MS), as a rapid and efficient means, now was used for the first time to screen antioxidants from Selaginella doederleinii.
Gang Wang, Shun Yao, Xiu-Xiu Zhang, Hang Song   +3 more
doaj   +1 more source