Results 51 to 60 of about 1,142 (187)
Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation
Biological and Pharmaceutical Bulletin, 2006 Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and ...
Hyun, Lim +4 more
openaire +3 more sources
Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage [PDF]
, 2019 Ginkgo biloba L. leaf extracts and herbal infusions are used worldwide due to the health benefits that are attributed to its use, including anti-neoplastic, anti-aging, neuro-protection, antioxidant and others. The aim of this study was to evaluate the
Gaivão, Isabel +6 more
core +2 more sources
Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
Biomedicine & Pharmacotherapy, 2017 The purpose of present study was to investigate anti-tumor activity of Ginkgetin (GK) and its mechanism of action in breast cancer. The effects of GK on growth of human breast cancer cell lines MDA-MB-231, BT-474 and MCF-7 were examined by MTT assay.
Jun, Cao +5 more
openaire +2 more sources
Status and challenges of plant-anticancer compounds in cancer treatment [PDF]
, 2021 Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve monochemotherapy or a combination of radiotherapy and mono-chemotherapy ...
Carpena Rodríguez, María +8 more
core +2 more sources
A Phenylpropanoid and Biflavonoids from the Needles of var.
Natural Product Communications, 2017 A phenylpropanoid [2-(3-methoxy-4-hydroxyphenyl)-propane-1,3-diol] (1) together with four known biflavonoids namely 7, 4′, 7′″, 4′″-tetra- O -methyl amentoflavone (2); 7, 4′, 7″-tri- O -methyl amentoflavone (3); ginkgetin (4); sequoiaflavone (5) were ...
Anju Mendiratta (Nee Chugh) +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs ...
Hui-Lin Pang +9 more
doaj +1 more source
Molecular Docking Analysis: Interaction Studies of Natural Compounds to Anti-inflammatory Targets [PDF]
, 2017 A variety of compounds from medicinal plants have been reported to possess anti-inflammatory properties. Selected natural compounds that exhibit anti-inflammatory properties were subjected to docking simulation using AutoDock Vina to investigate their ...
Herowati, Rina, Widodo, Gunawan Pamudji
core +2 more sources
Molecules, 2014 The effects of extraction time, temperature, pressure and different concentration of ethanol and their interactions on the yields of amentoflavone, quercetin and ginkgetin extracted from Taxus chinensis by supercritical CO2 were investigated by using a ...
Xiao Ruan +5 more
doaj +1 more source
IN-VITRO SCREENING OF THEAFLAVIN AND GINKGETIN ON A549 LUNG CANCER CELL LINE
Towards Excellence, 2020 Cancer is a complex, multi-gene, multi-step disease occurring as a result of a sequential accumulation of genetic and epigenetic changes. Death due to cancer rank second among all cause of death globally. Dysregulation of signaling pathway e.g. HGF/c-MET which were otherwise activated during embryonic development contributes to malignant transformation
Nisarg Vyas, Ram Tej Verma
openaire +1 more source
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source