Results 71 to 80 of about 1,142 (187)

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

BioMed Research International, Volume 2026, Issue 1, 2026.
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Aniket Singh, Sanjeev Kumar Sahu, Anil Kumar Sah, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source

Traditionaly utilization of Selaginella; field research and literature review [PDF]

, 2009
Setyawan AD. 2009. Traditionaly utilization of Selaginella; field research and literature review. Nusantara Bioscience 1: 146-154. The aims of this research were to find out traditional usage of Selaginella in medication and its other usages ...
SETYAWAN, AHMAD DWI
core  

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1

Folia Neuropathologica, 2019
The present investigation evaluates the protective effect of Ginkgetin aglycone (GA) against ischemic stroke-induced neuronal injury. Ischemic stroke was produced by the middle cerebral artery occlusion (MCAO) model and animals were a group that received
Bing Xu, Xin He, Yi Sui, Xu Wang, Xia Wang, Li Ren, Yun-Xin Zhai   +6 more
doaj   +1 more source

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Ferroptosis, a controlled cell death influenced by iron‐dependent lipid peroxidation, presents potential therapeutic targets for cancer treatment due to its unique molecular pathways and potential drug resistance. Natural compounds, such as polyphenols, flavonoids, terpenoids and alkaloids, can influence ferroptosis via important signalling ...
Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam, Patibandla Jahnavi, Jeetendra Kumar Gupta, Varikalla Rajashakar, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, G. Dharmamoorthy, Uppuluri Varuna Naga Venkata Arjun, Voleti Vijaya Kumar, Muath Suliman, Talha Bin Emran   +12 more
wiley   +1 more source

Natural and Nature-Derived Products Targeting Human Coronaviruses [PDF]

, 2021
The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific community before a state of emergency that needs to be addressed with intensive research for the
Alexis, Michael N., Corona, Angela, Skaltsounis, Alexios-Leandros, Tramontano, Enzo, Vougogiannopoulou, Konstantina   +4 more
core   +1 more source

Millet Bran Bound Phenolic Compounds Suppresses LPS‐Induced Inflammatory Response in Macrophages and Liver Injury Mice via TLR4/NF‐κB Signaling Pathway

eFood, Volume 6, Issue 4, August 2025.
BPS‐2 alleviates liver injury mice and RAW264.7 cell inflammation via TLR4/NF‐κB pathway. ABSTRACT Millet bran, rich in bioactive phenolic compounds, holds potential for both nutritional and therapeutic applications. In this study, bound phenolic compounds were isolated from millet bran, yielding a potent fraction named BPS‐2.
Ying‐kun Cai, Jin‐yue Sun, Ying‐ying Chen, Meng‐qi Zhang, Shu‐tao Sun, Qi‐dong Ren, Mu‐xuan Wang, Mohamed A. Farag, Bo Zhang, Xu Guo, Chao Liu   +10 more
wiley   +1 more source

Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-κB pathway

Cellular and Molecular Biology, 2019
Effect of ginkgetin on proliferation of human cervical cancer (HeLa) cells and the underlying mechanism   were investigated. Human cervical cancer (HeLa) cells were cultured at 37 °C in 10 % fetal bovine serum (FBS) supplemented RPMI 1640 medium in a humidified incubator containing 5 % CO2.
Jianxia, Cheng, Yun, Li, Jianping, Kong
openaire   +3 more sources

Quality evaluation of compounds in leaves of six Taxus species based on UPLC-MS/MS and chemometrics

Frontiers in Chemistry, 2023
Introduction:Taxus species are used as medicinal plants all over the world. The leaves of Taxus species are sustainable medicinal resources that are rich in taxoids and flavonoids.
Qingzhu Cai, Qiang Song, Kunxia Jiang, Yao Lin, Ying Zhang, Jirong Zhang, Shuqing Lin, Lina Huang, Qihuang Xue, Zehao Huang, Wen Xu, Wei Xu, Mun Fei Yam, Mun Fei Yam   +13 more
doaj   +1 more source