Results 81 to 90 of about 1,142 (187)
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
Natural products targeting tumour angiogenesis
British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source
Syntheses of Ring-substituted Flavonoids and Allied Compounds. X. Synthesis of Ginkgetin.
Chemical and Pharmaceutical Bulletin, 1963 The condensation of 3'-iodo-5-benzoyloxy-4', 7-dimethoxyflavone and 5-benzoyloxy-8-iodo-4', 7-dibenzyloxyflavone was carried out at 225∼230°for 40 minutes, with activated copper powder. The chloroform extract of the reaction mixture was heated with 10% H2SO4 in AcOH at 110° for 10 minutes to hydrolyze benzoyl and benzyl groups.
Koichi Nakazawa, Manzo Ito
openaire +2 more sources
KEGUNAAN GINKGO BILOBA UNTUK PENGOBATAN PENYAKIT NEUROLOGIS [PDF]
, 2020 Ginkgo Biloba adalah Salah satu tanaman yang tergolong sebagai fitofarmaka atau obat-obatan yang berasal dari tanaman ialah Ginkgo biloba Tanaman G.biloba (Gb) termasuk dalam familia Ginkgoceae.
Annisa, Nurul +1 more
core +1 more source
Artesunate induces ferroptosis in osteosarcoma through NCOA4‐mediated ferritinophagy
The FASEB Journal, Volume 39, Issue 7, 15 April 2025.The graphic abstract of this research, and the detailed description are in the abstract. Abstract Osteosarcoma (OS) is a prevalent primary malignant bone tumor that lacks effective therapeutic interventions. Artesunate (ART) has been proved to have remarkable treatment effects on severe malaria and anti‐tumor properties. This study aimed to investigate
Rui Huang +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 9, March 6, 2025.During the progression of liver cirrhosis, mitochondrial injury in hepatocytes promotes the release of mtDNA‐enriched EVs, which further activate cGAS‐STING signaling in skeletal muscle macrophages by shedding mtDNA. Conversely, targeted inhibition of hepatic EV secretion or STING signaling can mitigate skeletal muscle inflammatory injury and atrophy ...
Xiaoli Fan +10 more
wiley +1 more source
Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor
Oncology Letters, 2017 Ginkgetin is a natural biflavonoid isolated from the leaves of Ginkgo biloba, and is characterized by its anti-inflammatory and anti-viral activities. Although numerous studies state that it has also antitumor activity, the anti-proliferative effect of ginkgetin and the underlying mechanism in breast cancer cells have not yet been investigated.
Yoonhwa, Park +9 more
openaire +3 more sources
, 2020 Mast cells play a critical role in type 1 hypersensitivity reactions. Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many ...
Barlow, James William +3 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.After ischemic stroke, resting microglia transform into pro‐inflammatory or anti‐inflammatory microglia under different conditions, respectively. Moreover, microglia respond to the environment by flexibly reprogramming intracellular metabolic pathways, thereby altering immune function, which mainly includes glucose metabolism, lipid metabolism, and ...
Jing Lv +8 more
wiley +1 more source
Inflammatory Disease Processes and Interactions with Nutrition [PDF]
, 2017 Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infected or damaged sites.
Albers, R. +20 more
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