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The Role of Biglycan in the Heart
Connective Tissue Research, 2008Biglycan, a member of the small leucine rich proteoglycan family, is known to be expressed in almost every tissue of our body. Although there are increasing amount of data on the biological role of biglycan, its cardiac function is still not totally clarified.
Erika, Bereczki, Miklós, Sántha
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Biglycan knockout mice: New models for musculoskeletal diseases
Glycoconjugate Journal, 2002Biglycan is a Class I Small Leucine Rich Proteoglycans (SLRP) that is localized on human chromosome Xq28-ter. The conserved nature of its intron-exon structure and protein coding sequence compared to decorin (another Class I SLRP) indicates the two genes may have arisen from gene duplication. Biglycan contains two chondroitin sulfate glycosaminoglycan (
Marian F, Young +3 more
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Expression and significance of biglycan in endometrial cancer
Archives of Gynecology and Obstetrics, 2013This study aimed to determine the expression level of biglycan in different lesion properties of endometrium and to investigate the possible function and prognostic value of biglycan in endometrial cancer.Immunohistochemical staining (IHC) and quantitative realtime reverse transcription polymerase chain reaction (qRT-PCR) were used to determine the ...
Yang, Liu +6 more
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cDNA sequence for bovine biglycan (PGI) protein core
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993The nucleotide sequence of the protein core for bovine aortic smooth muscle cell biglycan was determined using recombinant DNA technology. Analysis of the deduced amino acid sequence for bovine biglycan revealed a striking homology, 94.6% and 95.7%, to human and rat biglycan, respectively.
M A, Torok, S A, Evans, J A, Marcum
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Developmental regulation of biglycan expression in muscle and tendon
Muscle & Nerve, 2006AbstractBiglycan is an extracellular ligand for the dystrophin‐associated protein complex (DAPC) that is upregulated in both dystrophic and regenerating muscle. Biglycan also binds to collagen VI, mutations of which cause a congenital muscular dystrophy (Ullrich's; UCMD) that is also characterized by connective tissue abnormalities.
Beatrice E, Lechner +3 more
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Biglycan and Decorin Expression and Distribution in Palatal Adhesion
Journal of Dental Research, 2017Previous studies demonstrated that chondroitin sulfate proteoglycans (CSPGs) on apical surfaces of palatal medial edge epithelial (MEE) cells were necessary for palatal adhesion. In this study, we identified 2 proteoglycans, biglycan and decorin, that were expressed in the palatal shelves prior to adhesion.
I, Ibrahim +3 more
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Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts
Basic Research in Cardiology, 2009Biglycan, a small leucine-rich proteoglycan, is essential for scar formation and preservation of hemodynamic function after myocardial infarction, as shown in biglycan-knockout mice. Because of this important role in cardiac pathophysiology, we aimed to identify regulators of biglycan expression and posttranslational modifications in cardiac ...
Tiede, Karen +2 more
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Lack of biglycan reduces contact hypersensitivity in mice
Contact Dermatitis, 2018Philipp R. Esser +3 more
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Decorin/biglycan regulation of corneal collagen fibrillogenesis
Matrix Biology, 2006G ZHANG, H SIMPSON, D BIRK
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