Salivary decorin as a potential noninvasive biomarker in chronic kidney disease: a comparative study with serum levels [PDF]
Renal FailureChronic kidney disease (CKD) is characterized by progressive renal fibrosis and irreversible loss of kidney function. Decorin, an extracellular matrix proteoglycan with antifibrotic properties, may reflect underlying fibrotic activity and has emerged as ...
Asena Serap Karatutlu +2 more
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Decorin levels and cardiometabolic function after endurance exercise [PDF]
Frontiers in PhysiologyIntroductionDecorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle.
Antônio Alves de Fontes-Junior +4 more
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Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Primary sarcopenia is an age‐associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age‐associated sarcopenia.
Xiaoqin Luo +9 more
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Possible dual role of decorin in abdominal aortic aneurysm. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation, which leads to pathological remodeling of the extracellular matrix. Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the
Koshiro Ueda +5 more
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Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. [PDF]
PLoS ONE, 2013 Decorin, a multifunctional small leucine-rich extracellular matrix proteoglycan, has been shown to possess potent antitumour activity. However, there is some uncertainty whether different cancer cells express decorin in addition to non-malignant stromal ...
Annele Sainio +7 more
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Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Matrix Biology Plus, 2022 Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach +8 more
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The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. [PDF]
PLoS ONE, 2012 Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by
Oliver Jungmann +8 more
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Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
EBioMedicine, 2020 Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor.
Na Jiang +9 more
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Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]
PLoS ONE, 2012 Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu +5 more
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Journal of the Formosan Medical Association, 2022 Background/purpose: Decorin is a small leucine-rich proteoglycan rich in extracellular matrix with potential antitumor activity. However, the role of decorin in hematological malignancies remains unclear, especially in the case of multiple myeloma (MM ...
Shang-Yi Huang +8 more
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