Results 1 to 10 of about 18,940 (249)

The Role of Decorin in Autoimmune and Inflammatory Diseases [PDF]

Journal of Immunology Research, 2022
Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj   +5 more sources

Role of Decorin in the Lens and Ocular Diseases

Cells, 2022
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P. Singh   +4 more
doaj   +4 more sources

Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction

npj Regenerative Medicine, 2023
Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, and recruitment, thus severely ...
Priya Mohindra, Justin X. Zhong, Qizhi Fang, Darnell L. Cuylear, Cindy Huynh, Huiliang Qiu, Dongwei Gao, Bhushan N. Kharbikar, Xiao Huang, Matthew L. Springer, Randall J. Lee, Tejal A. Desai   +11 more
doaj   +2 more sources

Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis

Journal of Experimental & Clinical Cancer Research, 2023
Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B.
Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen, Liangjing Wang   +7 more
doaj   +2 more sources

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Acta Neuropathologica Communications, 2022
Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson   +24 more
doaj   +2 more sources

Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis

Osteoarthritis and Cartilage, 2021
Objective: To delineate the activities of decorin and biglycan in the progression of post-traumatic osteoarthritis (PTOA). Design: Three-month-old inducible biglycan (BgniKO) and decorin/biglycan compound (Dcn/BgniKO) knockout mice were subjected to the ...
Ling Qin, Biao Han, Dehan Kong
exaly   +2 more sources

Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice

Journal of Sport and Health Science
Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. The purpose of this study was to examine the mechanisms behind the protective effects of exercise.
Marit Hjorth, Casey L. Egan, Guilherme D. Telles, Martin Pal, David Gallego-Ortega, Oliver K. Fuller, Emma D. McLennan, Ryan D. Gillis, Tae Gyu Oh, George E.O. Muscat, Surafel Tegegne, Michael S.M. Mah, Joanna Skhinas, Emma Estevez, Timothy E. Adams, Matthew J. McKay, Mark Molloy, Kevin I. Watt, Hongwei Qian, Paul Gregorevic, Thomas R. Cox, Pernille Hojman, Julie Midtgaard, Jesper F. Christensen, Martin Friedrichsen, Renato V. Iozzo, Erica K. Sloan, Brian G. Drew, Jørgen F.P. Wojtaszewski, Martin Whitham, Mark A. Febbraio   +30 more
doaj   +2 more sources

Decorin Suppresses Invasion and EMT Phenotype of Glioma by Inducing Autophagy via c-Met/Akt/mTOR Axis

Frontiers in Oncology, 2021
Decorin exhibits inhibitory effects in tumorigenesis in various types of cancers. The clinical characteristics of 42 patients with GBM were reviewed and analyzed.
Yanfei Jia, Qian Feng, Bo Tang, Xiaodong Luo, Qiang Yang, Hu Yang, Qiang Li   +6 more
doaj   +2 more sources

Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis

EBioMedicine, 2020
Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor.
Na Jiang, Qing Zhang, Mel KM Chau, Ming S Yip, Sing Leung Lui, Stephanie Liu, Kent Man Chu, Hextan YS Ngan, Tak Mao Chan, Susan Yung   +9 more
doaj   +2 more sources

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix

ACS Nano, 2019
Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding the molecular activities that govern cartilage matrix assembly is critical for developing effective cartilage regeneration strategies.
Ling Qin, X Lucas Lu, X Sherry Liu
exaly   +2 more sources