The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. [PDF]
PLoS ONE, 2012 Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by
Oliver Jungmann +8 more
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Decorin levels and cardiometabolic function after endurance exercise [PDF]
Frontiers in PhysiologyIntroductionDecorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle.
Antônio Alves de Fontes-Junior +4 more
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Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes [PDF]
BioengineeringDuring corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its ...
Nathaniel S. Tjahjono +6 more
doaj +2 more sources
Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Primary sarcopenia is an age‐associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age‐associated sarcopenia.
Xiaoqin Luo +9 more
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Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid–Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis [PDF]
LifeIn patients on chronic peritoneal dialysis (PD), aortic stiffness (AS) is a common cardiovascular condition that can predict cardiovascular events and mortality. Decorin is a small leucine-rich proteoglycan that plays a vital role in extracellular matrix
Yahn-Bor Chern +5 more
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Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model [PDF]
, 2012 Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and ...
Buraschi, Simone +10 more
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Possible dual role of decorin in abdominal aortic aneurysm. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation, which leads to pathological remodeling of the extracellular matrix. Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the
Koshiro Ueda +5 more
doaj +1 more source
Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. [PDF]
PLoS ONE, 2013 Decorin, a multifunctional small leucine-rich extracellular matrix proteoglycan, has been shown to possess potent antitumour activity. However, there is some uncertainty whether different cancer cells express decorin in addition to non-malignant stromal ...
Annele Sainio +7 more
doaj +1 more source
Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Matrix Biology Plus, 2022 Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach +8 more
doaj +1 more source
Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]
PLoS ONE, 2012 Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu +5 more
doaj +1 more source